Strain Name:
C57BL/6J-MtgxR4037Btlr/Mmmh
Stock Number:
040964-MU
Citation ID:
RRID:MMRRC_040964-MU
Other Names:
R4037 (G1), C57BL/6J-MtgxR4037Btlr
Major Collection:

Gene Information

Pax4
Name: paired box 4
Synonyms: Pax-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18506
HGNC: HGNC:8618
Homologene: 4515
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: seladin-1, 5830417J06Rik, 2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Mmachc
Name: methylmalonic aciduria cblC type, with homocystinuria
Synonyms: 1810037K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67096
Homologene: 12082
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: Aprf, 1110034C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20848
Homologene: 7960
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Ruvbl1
Name: RuvB-like protein 1
Synonyms: 2510009G06Rik, Pontin52, Tip49a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56505
Homologene: 37839
Hspb8
Name: heat shock protein 8
Synonyms: E2IG1, HSP22, HSP20-like, D5Ucla4, Cryac, H11, H11K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 80888
Homologene: 8654
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: 128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20017
Homologene: 7133
Dcc
Name: deleted in colorectal carcinoma
Synonyms: Igdcc1, C030036D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: 5730590A01Rik, 1200013P10Rik, crn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66877
Homologene: 6462
Ttyh1
Name: tweety family member 1
Synonyms: 6330408P11Rik, 4930459B04Rik, tty
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57776
Homologene: 10779
Dennd1c
Name: DENN/MADD domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70785
VEGA: 17
Homologene: 11773
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: AMPKalpha2, 2310008I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545370
Homologene: 23741
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70083
VEGA: 17
Homologene: 11432
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: AIB3, RAP250, PRIP, NRC, ASC2, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56406
Homologene: 137337
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70155
Homologene: 11595
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: Ata3, 1110012E16Rik, 1700012A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 69354
VEGA: 15
Homologene: 75077
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69983
Homologene: 37424
Slc36a2
Name: solute carrier family 36 (proton/amino acid symporter), member 2
Synonyms: A530067G19Rik, Tramd1, PAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 246049
Homologene: 72100
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242627
Homologene: 135888
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: TAT1, Mct10, 2610103N14Rik, PRO0813
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72472
VEGA: 10
Homologene: 75089
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1alpha, RIM1, C030033M19Rik, RIM1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 116837
Homologene: 128399
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Vmn1r218
Name: vomeronasal 1 receptor 218
Synonyms: V1ri5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171256
Homologene: 110880
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, Plcl4, PLCeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269615
Homologene: 85172
Sntb1
Name: syntrophin, basic 1
Synonyms: 59-1 DAP, beta1-Syntrophin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20649
Homologene: 9618
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230815
Homologene: 69303
Efcc1
Name: EF hand and coiled-coil domain containing 1
Synonyms: Ccdc48, AB041550
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58229
Homologene: 130011
Wipf3
Name: WAS/WASL interacting protein family, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330319
Homologene: 113391
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: activated p21cdc42Hs kinase, ACK1, P21cdc42Hs kinase, Pyk1, Ack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 51789
Homologene: 4224
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21934
Homologene: 2848
Olfr1218
Name: olfactory receptor 1218
Synonyms: GA_x6K02T2Q125-50536041-50535106, MOR233-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258815
Homologene: 73986
Cers3
Name: ceramide synthase 3
Synonyms: T3L, Lass3, LOC233330, related to TRH3, CerS3, 4930550L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545975
Homologene: 18719
Olfr1246
Name: olfactory receptor 1246
Synonyms: MOR231-9, GA_x6K02T2Q125-51034790-51033846
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258788
Homologene: 74246
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70893
Homologene: 72240
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Gpr137c
Name: G protein-coupled receptor 137C
Synonyms: LOC380893, 6330416L11Rik, TM7SF1L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70713
Homologene: 28613
Capn6
Name: calpain 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 12338
HGNC: HGNC:1483
Homologene: 7252
Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
Synonyms: Fam86, 5730409G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 70511
Homologene: 45719
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,475,712 bp
  • T to C, chromosome 1 at 23,378,964 bp
  • A to G, chromosome 1 at 105,827,739 bp
  • T to A, chromosome 1 at 150,772,502 bp
  • A to G, chromosome 2 at 89,054,688 bp
  • C to T, chromosome 2 at 89,591,035 bp
  • A to G, chromosome 2 at 129,105,236 bp
  • T to A, chromosome 2 at 145,932,327 bp
  • G to A, chromosome 2 at 155,407,370 bp
  • T to C, chromosome 3 at 72,928,602 bp
  • T to C, chromosome 4 at 105,051,247 bp
  • T to C, chromosome 4 at 106,573,878 bp
  • G to T, chromosome 4 at 113,885,814 bp
  • T to A, chromosome 4 at 116,706,018 bp
  • C to T, chromosome 4 at 134,593,339 bp
  • T to A, chromosome 4 at 154,998,839 bp
  • A to G, chromosome 5 at 116,409,344 bp
  • A to G, chromosome 6 at 28,443,883 bp
  • G to A, chromosome 6 at 54,481,828 bp
  • C to T, chromosome 6 at 87,731,508 bp
  • T to A, chromosome 6 at 88,473,135 bp
  • T to C, chromosome 7 at 4,133,346 bp
  • T to A, chromosome 7 at 66,781,863 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • A to C, chromosome 9 at 26,829,047 bp
  • G to C, chromosome 10 at 40,056,624 bp
  • T to C, chromosome 11 at 55,164,275 bp
  • C to T, chromosome 11 at 100,893,125 bp
  • T to C, chromosome 11 at 104,507,207 bp
  • T to C, chromosome 11 at 113,795,055 bp
  • T to C, chromosome 12 at 76,405,768 bp
  • T to C, chromosome 13 at 23,136,801 bp
  • C to A, chromosome 14 at 45,220,230 bp
  • G to A, chromosome 15 at 55,792,020 bp
  • A to G, chromosome 15 at 64,725,470 bp
  • G to A, chromosome 15 at 96,997,042 bp
  • A to T, chromosome 16 at 5,245,271 bp
  • G to T, chromosome 16 at 32,670,796 bp
  • A to G, chromosome 16 at 36,956,625 bp
  • T to C, chromosome 17 at 25,795,010 bp
  • C to T, chromosome 17 at 29,159,113 bp
  • A to C, chromosome 17 at 57,070,638 bp
  • A to G, chromosome 18 at 72,350,397 bp
  • A to G, chromosome X at 143,807,863 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4037 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040964-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.