Strain Name:
C57BL/6J-MtgxR4041Btlr/Mmmh
Stock Number:
040966-MU
Citation ID:
RRID:MMRRC_040966-MU
Other Names:
R4041 (G1), C57BL/6J-MtgxR4041Btlr
Major Collection:

Strain Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Cfl1
Name: cofilin 1, non-muscle
Synonyms: cofilin, Cof, n-cofilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12631
HGNC: HGNC:1874
Homologene: 99735
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237898
Homologene: 13066
Mbnl2
Name: muscleblind like splicing factor 2
Synonyms: 1110002M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105559
VEGA: 14
Homologene: 76766
Krit1
Name: KRIT1, ankyrin repeat containing
Synonyms: Krit1, Krit1B, Krit1A, 2010007K12Rik, A630036P20Rik, Ccm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79264
HGNC: HGNC:1573
Homologene: 12746
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: D10Ertd802e, CVAK104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213326
Homologene: 13349
Wnt3a
Name: wingless-type MMTV integration site family, member 3A
Synonyms: Wnt-3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22416
Homologene: 22528
Lrrn4cl
Name: LRRN4 C-terminal like
Synonyms: 1110067I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68852
VEGA: 19
Homologene: 45730
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
Hexim1
Name: hexamethylene bis-acetamide inducible 1
Synonyms: HIS1, CLP-1, 7330426E13Rik, Clp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192231
Homologene: 31382
Dusp27
Name: dual specificity phosphatase 27 (putative)
Synonyms: C130085G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240892
Homologene: 18949
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: 2010205A06Rik, 1810013D05Rik, Zip5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72002
VEGA: 10
Homologene: 57083
Zfp420
Name: zinc finger protein 420
Synonyms: B230312I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233058
Homologene: 129731
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, Clc1, NMF355, nmf355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Klk1
Name: kallikrein 1
Synonyms: mGk-6, 0610007D04Rik, Klk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16612
Homologene: 68141
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Or2bd2
Name: olfactory receptor family 2 subfamily BD member 2
Synonyms: GA_x6K02T2QGBW-3169916-3170881, MOR124-1, 4930415J05Rik, Olfr1344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257882
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243659
Homologene: 49545
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Krt7
Name: keratin 7
Synonyms: K7, D15Wsu77e, Cytokeratin 7, Krt2-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110310
HGNC: HGNC:6445
Homologene: 4058
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 215384
Homologene: 68369
Irgm2
Name: immunity-related GTPase family M member 2
Synonyms: Gtpi, Iigp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54396
Homologene: 78363
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Atf5
Name: activating transcription factor 5
Synonyms: AFTA, Atf7, Atfx, ODA-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 107503
HGNC: HGNC:790
Homologene: 32142
Cage1
Name: cancer antigen 1
Synonyms: CAGE1, 4933427I01Rik, Ctag3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71213
Homologene: 18484
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,081,495 bp
  • C to A, chromosome 1 at 116,184,399 bp
  • T to C, chromosome 1 at 166,100,111 bp
  • A to G, chromosome 2 at 69,670,710 bp
  • A to G, chromosome 4 at 88,643,991 bp
  • G to C, chromosome 5 at 3,809,642 bp
  • A to G, chromosome 6 at 42,309,968 bp
  • A to T, chromosome 6 at 131,312,917 bp
  • T to C, chromosome 7 at 6,440,689 bp
  • A to G, chromosome 7 at 28,113,979 bp
  • A to T, chromosome 7 at 29,085,931 bp
  • T to C, chromosome 7 at 29,876,002 bp
  • A to T, chromosome 7 at 44,229,562 bp
  • G to A, chromosome 7 at 44,342,162 bp
  • T to C, chromosome 7 at 44,813,497 bp
  • T to A, chromosome 10 at 89,650,052 bp
  • T to C, chromosome 10 at 127,743,554 bp
  • T to C, chromosome 10 at 128,396,468 bp
  • A to G, chromosome 11 at 58,220,130 bp
  • G to A, chromosome 11 at 59,051,531 bp
  • G to T, chromosome 11 at 59,249,644 bp
  • A to G, chromosome 11 at 85,017,739 bp
  • A to G, chromosome 11 at 103,117,106 bp
  • A to G, chromosome 13 at 38,019,177 bp
  • A to T, chromosome 14 at 115,133,216 bp
  • C to T, chromosome 14 at 120,389,074 bp
  • T to A, chromosome 15 at 101,423,280 bp
  • A to G, chromosome 18 at 82,664,996 bp
  • T to C, chromosome 19 at 5,492,528 bp
  • G to T, chromosome 19 at 5,751,871 bp
  • T to A, chromosome 19 at 8,852,104 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040966-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.