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Strain Name:
C57BL/6J-MtgxR4119Btlr/Mmmh
Stock Number:
040992-MU
Citation ID:
RRID:MMRRC_040992-MU
Other Names:
R4119 (G1), C57BL/6J-MtgxR4119Btlr
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: Enx-1, Enx1h, KMT6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382038
Homologene: 8859
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Itpr-1, Ip3r, Pcp-1, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: B230217J03Rik, 9330189K18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1, Krim-1B, Krim-1A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224691
Homologene: 77422
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: WBP15, Nadrin, Rich1, 5730403H17Rik, Nadrin2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Aplnr
Name: apelin receptor
Synonyms: msr/apj, apelin receptor, APJ, Agtrl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23796
HGNC: HGNC:339
Homologene: 3784
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76872
Homologene: 51873
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57775
Homologene: 49641
Zkscan3
Name: zinc finger with KRAB and SCAN domains 3
Synonyms: 2810435N07Rik, Skz1, Zfp307, Zfp306
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72739
Homologene: 130732
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: NY-CO-33, D18Bwg1409e, 5730407I04Rik, Mtsh1, Sdccag33, teashirt1, Tsh1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 9530006G20Rik, 1110069I04Rik, 2310068J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Hars2
Name: histidyl-tRNA synthetase 2
Synonyms: HARSR, HO3, 4631412B19Rik, Harsl
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70791
HGNC: HGNC:4817
Homologene: 40819
Or5d16
Name: olfactory receptor family 5 subfamily D member 16
Synonyms: GA_x6K02T2Q125-49426894-49425950, MOR174-10, Olfr1155
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258636
Homologene: 133739
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263803
Homologene: 50980
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: LOC210962, Gm597
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: 1500005N04Rik, Ihpk2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76500
Homologene: 56929
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Bcas1
Name: brain enriched myelin associated protein 1
Synonyms: NABC1, 2210416M21Rik, 9030223A09Rik, breast carcinoma amplified sequence 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76960
HGNC: HGNC:974
Homologene: 2714
1700013D24Rik
Name: RIKEN cDNA 1700013D24 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76921
Homologene: 135963
Fibin
Name: fin bud initiation factor homolog (zebrafish)
Synonyms: Fibin, 1110018M03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67606
Homologene: 12163
Or10ag57
Name: olfactory receptor family 10 subfamily AG member 57
Synonyms: GA_x6K02T2Q125-48880078-48881058, MOR264-1, Olfr1122
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259033
Homologene: 73977
Ripor1
Name: RHO family interacting cell polarization regulator 1
Synonyms: 2310066E14Rik, Fam65a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75687
Homologene: 11564
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Vmn2r39
Name: vomeronasal 2, receptor 39
Synonyms: EG545909
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545909
Homologene: 113703
Zfp24
Name: zinc finger protein 24
Synonyms: KOX17, ZF-12, 3526401F17Rik, 5033419P20Rik, Zfp191
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 59057
Homologene: 5068
A230060F14Rik
Name: RIKEN cDNA A230060F14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 28,777,973 bp
  • A to T, chromosome 1 at 60,291,870 bp
  • A to G, chromosome 1 at 189,653,045 bp
  • A to G, chromosome 2 at 30,083,037 bp
  • T to A, chromosome 2 at 31,801,727 bp
  • T to C, chromosome 2 at 85,136,966 bp
  • T to A, chromosome 2 at 87,387,843 bp
  • A to G, chromosome 2 at 87,943,443 bp
  • A to G, chromosome 2 at 110,362,690 bp
  • T to A, chromosome 2 at 119,757,948 bp
  • T to A, chromosome 2 at 120,064,529 bp
  • G to C, chromosome 2 at 170,378,815 bp
  • T to C, chromosome 3 at 28,666,175 bp
  • T to C, chromosome 3 at 59,217,841 bp
  • A to G, chromosome 3 at 104,467,195 bp
  • T to A, chromosome 3 at 123,117,150 bp
  • A to G, chromosome 4 at 8,785,658 bp
  • C to T, chromosome 6 at 25,688,426 bp
  • A to C, chromosome 6 at 47,544,548 bp
  • G to A, chromosome 6 at 108,394,355 bp
  • A to G, chromosome 6 at 124,356,904 bp
  • T to C, chromosome 7 at 3,717,575 bp
  • T to A, chromosome 7 at 6,962,806 bp
  • G to A, chromosome 7 at 9,023,674 bp
  • A to G, chromosome 7 at 123,306,994 bp
  • A to T, chromosome 7 at 144,284,941 bp
  • T to A, chromosome 8 at 105,618,857 bp
  • T to C, chromosome 8 at 122,863,423 bp
  • T to A, chromosome 8 at 124,047,240 bp
  • G to A, chromosome 9 at 108,805,648 bp
  • C to A, chromosome 10 at 86,021,895 bp
  • C to A, chromosome 11 at 3,683,868 bp
  • G to A, chromosome 11 at 72,714,484 bp
  • T to C, chromosome 11 at 115,873,492 bp
  • C to T, chromosome 12 at 113,544,574 bp
  • T to C, chromosome 13 at 11,779,267 bp
  • T to C, chromosome 13 at 21,393,949 bp
  • A to G, chromosome 13 at 92,354,011 bp
  • A to C, chromosome 15 at 10,539,920 bp
  • A to G, chromosome 16 at 14,394,013 bp
  • A to G, chromosome 16 at 17,142,187 bp
  • T to C, chromosome 17 at 4,995,794 bp
  • T to A, chromosome 17 at 32,978,215 bp
  • A to G, chromosome 18 at 24,014,569 bp
  • A to T, chromosome 18 at 36,790,488 bp
  • T to G, chromosome 18 at 84,014,189 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4119 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040992-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.