Strain Name:
C57BL/6J-MtgxR4157Btlr/Mmmh
Stock Number:
041000-MU
Citation ID:
RRID:MMRRC_041000-MU
Other Names:
R4157 (G1), C57BL/6J-MtgxR4157Btlr
Major Collection:

Gene Information

Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224656
Homologene: 2569
Cdk8
Name: cyclin-dependent kinase 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: Lgals5, galectin-9, LGALS35, gal-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16859
Homologene: 134662
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66875
Homologene: 32355
Shroom3
Name: shroom family member 3
Synonyms: Shrm, Shrm3, D5Ertd287e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: Zfra, FE65L1, Rirl1, TR2L, 2310007D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68925
Homologene: 32269
Wdr20
Name: WD repeat domain 20
Synonyms: Wdr20a, 2310040A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69641
Homologene: 32684
Arl6ip1
Name: ADP-ribosylation factor-like 6 interacting protein 1
Synonyms: AIP-6, ARMER
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54208
HGNC: HGNC:697
Homologene: 41008
Ndufs4
Name: NADH:ubiquinone oxidoreductase core subunit S4
Synonyms: C1-18k, 6720411N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17993
VEGA: 13
HGNC: HGNC:7711
Homologene: 1866
Git1
Name: GIT ArfGAP 1
Synonyms: Cat-1, p95Cat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216963
HGNC: HGNC:4272
Homologene: 32204
Cisd2
Name: CDGSH iron sulfur domain 2
Synonyms: B630006A20Rik, Zcd2, 1500009M05Rik, 1500031D15Rik, 1500026J14Rik, Miner1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67006
Homologene: 36436
Ppp4r3a
Name: protein phosphatase 4 regulatory subunit 3A
Synonyms: 1110034C04Rik, Smek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68734
VEGA: 12
Homologene: 69510
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Degs1
Name: delta(4)-desaturase, sphingolipid 1
Synonyms: Mdes, Des1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13244
Homologene: 55770
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Zfp748
Name: zinc finger protein 748
Synonyms: Zfp208, 2610014M12Rik, KRAB-O, mszf54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212276
Homologene: 134552
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 272347
Homologene: 12358
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232339
Homologene: 45968
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: cI-27, SAC2, 5830435P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101490
Homologene: 8962
Tns2
Name: tensin 2
Synonyms: nph, Tenc1, nep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Pde9a
Name: phosphodiesterase 9A
Synonyms: PDE9A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18585
HGNC: HGNC:8795
Homologene: 113565
Adamts7
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75767
Homologene: 11853
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: 9130430L19Rik, Rit1, B630002E05Rik, CTIP2, COUP-TF interacting protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
C4b
Name: complement component 4B (Chido blood group)
Synonyms: C4, Ss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Tns1
Name: tensin 1
Synonyms: E030018G17Rik, E030037J05Rik, 1110018I21Rik, Tns, 1200014E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94089
Homologene: 14113
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Gm1141
Name: predicted gene 1141
Synonyms: LOC382221, Pasd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 382221
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74762
Homologene: 17780
Gm3486
Name: predicted gene 3486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
1700123L14Rik
Name: RIKEN cDNA 1700123L14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78482
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: LOC269037, Gm672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
Pidd1
Name: p53 induced death domain protein 1
Synonyms: 1200011D09Rik, Lrdd, Pidd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57913
Homologene: 11220
Ecd
Name: ecdysoneless cell cycle regulator
Synonyms: 5730461K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70601
VEGA: 14
Homologene: 5256
Orm2
Name: orosomucoid 2
Synonyms: Orm-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18406
HGNC: HGNC:8499
Homologene: 130632
Oog2
Name: oogenesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381570
Homologene: 77858
Snx22
Name: sorting nexin 22
Synonyms: LOC382083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382083
VEGA: 9
Homologene: 11723
Adamtsl5
Name: ADAMTS-like 5
Synonyms: Thsd6, 2010109H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66548
Homologene: 19803
Ccpg1
Name: cell cycle progression 1
Synonyms: 1810073J13Rik, D9Ertd392e, 9430028F23Rik, 1700030B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72278
Homologene: 3487
Krt9
Name: keratin 9
Synonyms: K9, Krt1-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107656
HGNC: HGNC:6447
Homologene: 138337
Srgn
Name: serglycin
Synonyms: Sgc, Prg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19073
HGNC: HGNC:9361
Homologene: 137238
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 673582
Dnajc4
Name: DnaJ heat shock protein family (Hsp40) member C4
Synonyms: Hspf2, Mcg18, 2010301J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 57431
VEGA: 19
HGNC: HGNC:5271
Homologene: 73264
Tmem54
Name: transmembrane protein 54
Synonyms: 1810017F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66260
Homologene: 11937
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 73,914,631 bp
  • A to T, chromosome 1 at 151,403,044 bp
  • A to G, chromosome 1 at 182,282,627 bp
  • A to G, chromosome 2 at 25,573,697 bp
  • T to C, chromosome 2 at 69,959,669 bp
  • C to T, chromosome 2 at 119,774,179 bp
  • G to T, chromosome 3 at 135,411,194 bp
  • A to G, chromosome 4 at 43,365,591 bp
  • T to A, chromosome 4 at 63,363,985 bp
  • G to A, chromosome 4 at 129,110,711 bp
  • A to G, chromosome 4 at 144,193,953 bp
  • G to A, chromosome 5 at 66,302,604 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • A to T, chromosome 5 at 146,299,449 bp
  • A to T, chromosome 6 at 47,835,909 bp
  • C to G, chromosome 6 at 96,165,283 bp
  • T to A, chromosome 6 at 118,507,821 bp
  • AAAATAAATAAATAAATAAATAAATA to AAAATAAATAAATAAATAAATAAATAAATA, chromosome 7 at 118,121,899 bp
  • C to T, chromosome 7 at 128,679,699 bp
  • A to G, chromosome 7 at 141,441,366 bp
  • A to T, chromosome 8 at 27,152,147 bp
  • A to G, chromosome 9 at 60,871,753 bp
  • T to C, chromosome 9 at 66,068,211 bp
  • C to A, chromosome 9 at 73,012,167 bp
  • G to T, chromosome 9 at 90,188,361 bp
  • A to G, chromosome 10 at 62,497,834 bp
  • C to T, chromosome 10 at 80,345,322 bp
  • A to G, chromosome 10 at 88,761,867 bp
  • T to C, chromosome 11 at 48,848,093 bp
  • T to C, chromosome 11 at 77,504,936 bp
  • C to A, chromosome 11 at 78,973,107 bp
  • T to A, chromosome 11 at 100,188,649 bp
  • C to T, chromosome 12 at 54,701,612 bp
  • G to A, chromosome 12 at 84,327,432 bp
  • T to C, chromosome 12 at 85,057,403 bp
  • A to G, chromosome 12 at 101,055,619 bp
  • A to T, chromosome 12 at 107,917,425 bp
  • G to A, chromosome 12 at 110,738,174 bp
  • G to A, chromosome 13 at 67,542,106 bp
  • A to T, chromosome 13 at 73,265,543 bp
  • A to T, chromosome 13 at 114,307,854 bp
  • A to G, chromosome 14 at 16,384,491 bp
  • A to G, chromosome 14 at 20,324,564 bp
  • G to A, chromosome 14 at 41,486,386 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • C to T, chromosome 17 at 28,202,283 bp
  • T to C, chromosome 17 at 29,833,343 bp
  • T to C, chromosome 17 at 31,466,399 bp
  • A to G, chromosome 17 at 34,742,855 bp
  • T to C, chromosome 18 at 75,435,270 bp
  • T to C, chromosome 19 at 6,989,840 bp
  • T to C, chromosome X at 71,939,555 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4157 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041000-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.