Strain Name:
C57BL/6J-MtgxR4171Btlr/Mmmh
Stock Number:
041011-MU
Citation ID:
RRID:MMRRC_041011-MU
Other Names:
R4171 (G1), C57BL/6J-MtgxR4171Btlr
Major Collection:

Strain Information

Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
Homologene: 115929
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76804
Homologene: 41004
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72508
Homologene: 81703
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68014
Homologene: 32381
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, Iir, 5330417C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229722
Homologene: 23249
Cd200r1
Name: CD200 receptor 1
Synonyms: OX2R, CD200R, Mox2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57781
Homologene: 10957
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50767
Homologene: 21333
2310022A10Rik
Name: RIKEN cDNA 2310022A10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66367
Homologene: 35272
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, Pep-7, LAP, peptidase S, Pep7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66988
Homologene: 41072
Nup54
Name: nucleoporin 54
Synonyms: 3110079L04Rik, 54kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269113
Homologene: 41169
Slc38a6
Name: solute carrier family 38, member 6
Synonyms: EG625098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 625098
Homologene: 27550
Igkv3-4
Name: immunoglobulin kappa variable 3-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 626347
Mep1b
Name: meprin 1 beta
Synonyms: meprin beta, Mep-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Itga1
Name: integrin alpha 1
Synonyms: CD49A, Vla1, E130012M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Sp100
Name: nuclear antigen Sp100
Synonyms: A430075G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20684
Homologene: 86761
Txndc17
Name: thioredoxin domain containing 17
Synonyms: 4831443O22Rik, TRP14, D11Ertd672e, Txnl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52700
Homologene: 41683
Lrrc17
Name: leucine rich repeat containing 17
Synonyms: 6130400C22Rik, 4833425M04Rik, 37kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74511
Homologene: 55929
Poll
Name: polymerase (DNA directed), lambda
Synonyms: 1110003P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56626
VEGA: 19
HGNC: HGNC:9184
Homologene: 40863
Reg2
Name: regenerating islet-derived 2
Synonyms: pancreatic thread protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19693
Homologene: 68517
Ifna6
Name: interferon alpha 6
Synonyms: Ifa6, Ifna8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15969
Homologene: 68536
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Zfp512b
Name: zinc finger protein 512B
Synonyms: LOC269401, Znf512b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269401
Homologene: 69314
Rftn2
Name: raftlin family member 2
Synonyms: 2700010E02Rik, 3222401M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74013
Homologene: 16954
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Apmap
Name: adipocyte plasma membrane associated protein
Synonyms: 2310001A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71881
Homologene: 41380
Or1e16
Name: olfactory receptor family 1 subfamily E member 16
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54, Olfr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Vmn1r44
Name: vomeronasal 1 receptor 44
Synonyms: V1rb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113854
Homologene: 113975
2410124H12Rik
Name: RIKEN cDNA 2410124H12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76785
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 111175
Homologene: 69255
Rab29
Name: RAB29, member RAS oncogene family
Synonyms: Rab7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226422
HGNC: HGNC:9789
Homologene: 20842
Or6c204
Name: olfactory receptor family 6 subfamily C member 204
Synonyms: GA_x6K02T2PULF-10872859-10871923, MOR114-15, Olfr773-ps1, Olfr773
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 257664
Homologene: 123776
B130024G19Rik
Name: RIKEN cDNA B130024G19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434198
Mettl6
Name: methyltransferase like 6
Synonyms: 1600013P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67011
VEGA: 14
Homologene: 12069
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 55,214,270 bp
  • A to T, chromosome 1 at 72,276,269 bp
  • T to C, chromosome 1 at 85,706,841 bp
  • A to G, chromosome 1 at 131,867,737 bp
  • A to C, chromosome 1 at 173,933,775 bp
  • A to G, chromosome 2 at 150,584,067 bp
  • G to A, chromosome 2 at 181,590,598 bp
  • G to T, chromosome 3 at 108,460,943 bp
  • A to G, chromosome 3 at 114,208,214 bp
  • T to A, chromosome 4 at 74,280,898 bp
  • T to C, chromosome 4 at 88,827,801 bp
  • A to G, chromosome 5 at 21,543,788 bp
  • T to C, chromosome 5 at 45,509,491 bp
  • A to G, chromosome 5 at 92,417,484 bp
  • G to A, chromosome 6 at 70,672,340 bp
  • G to A, chromosome 6 at 78,406,591 bp
  • T to A, chromosome 6 at 89,894,014 bp
  • A to G, chromosome 7 at 27,565,684 bp
  • C to T, chromosome 7 at 70,388,706 bp
  • A to G, chromosome 7 at 118,649,587 bp
  • A to G, chromosome 8 at 3,543,997 bp
  • T to A, chromosome 9 at 64,158,715 bp
  • C to T, chromosome 10 at 127,742,367 bp
  • G to A, chromosome 10 at 129,186,584 bp
  • C to T, chromosome 11 at 5,039,161 bp
  • T to C, chromosome 11 at 72,207,711 bp
  • A to C, chromosome 11 at 73,395,539 bp
  • T to C, chromosome 11 at 86,544,579 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to C, chromosome 11 at 113,866,989 bp
  • G to A, chromosome 12 at 61,843,382 bp
  • T to A, chromosome 12 at 73,350,552 bp
  • G to A, chromosome 13 at 115,030,886 bp
  • T to C, chromosome 14 at 31,493,667 bp
  • A to G, chromosome 16 at 44,792,764 bp
  • T to C, chromosome 16 at 92,497,061 bp
  • T to A, chromosome 18 at 20,458,579 bp
  • A to T, chromosome 18 at 21,095,106 bp
  • T to C, chromosome 19 at 45,556,053 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4171 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041011-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.