Strain Name:
C57BL/6J-MtgxR4181Btlr/Mmmh
Stock Number:
041017-MU
Citation ID:
RRID:MMRRC_041017-MU
Other Names:
R4181 (G1), C57BL/6J-MtgxR4181Btlr
Major Collection:

Gene Information

Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: JNK1, c-Jun N-terminal kinase, Prkm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109267
Homologene: 34137
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 75415
Homologene: 23089
Pdss1
Name: prenyl (solanesyl) diphosphate synthase, subunit 1
Synonyms: mSPS1, 2700031G06Rik, Tprt, 2610203G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56075
Homologene: 5353
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: mStbm, stbm, Lpp2, KITENIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229658
Homologene: 44540
Ddx1
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E130317O14Rik, Hnrpul1, E1B-AP5, E1BAP5, Hnrnpul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232989
Homologene: 31419
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, GMAP-210, TRIP230, 6030460N08Rik, 2610511G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109181
Homologene: 20897
Clic4
Name: chloride intracellular channel 4 (mitochondrial)
Synonyms: mc3s5, mtCLIC, D0Jmb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29876
Homologene: 8490
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: C030034J04Rik, 4933422O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 74775
Homologene: 10011
Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Synonyms: Gapd, Gapd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14433
HGNC: HGNC:4141
Homologene: 107053
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 195531
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Rorc
Name: RAR-related orphan receptor gamma
Synonyms: RORgamma, Thor, thymus orphan receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19885
Homologene: 21051
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Fyb
Name: FYN binding protein
Synonyms: ADAP, FYB-120/130, B630013F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Fam38b, Piezo2, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667742
Homologene: 49695
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9630046L06Rik, 9430004C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268747
VEGA: 14
Homologene: 74564
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76295
Homologene: 32919
Lpcat3
Name: lysophosphatidylcholine acyltransferase 3
Synonyms: Oact5, Mboat5, Grcc3f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14792
Homologene: 14678
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 81877
Homologene: 49589
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: Oasl10, 2'-5' oligoadenylate synthetase-like 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269701
Homologene: 16964
Cmpk2
Name: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Synonyms: Tyki, TDKI, 1200004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 22169
VEGA: 12
Homologene: 10748
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381260
Homologene: 124277
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, 1700052O22Rik, MX, 4931438M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Olfr1055
Name: olfactory receptor 1055
Synonyms: MOR186-1, GA_x6K02T2Q125-47819205-47818258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 259023
Homologene: 131140
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269152
Homologene: 18623
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: LOC381738, b2b1654Clo, Gm1060, Ccdc164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381738
Homologene: 35977
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22404
Homologene: 7997
Gtpbp3
Name: GTP binding protein 3
Synonyms: Gtpbp3, 2410009F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 70359
Homologene: 6600
Bcas1
Name: breast carcinoma amplified sequence 1
Synonyms: 2210416M21Rik, 9030223A09Rik, NABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76960
HGNC: HGNC:974
Homologene: 2714
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Olfr747
Name: olfactory receptor 747
Synonyms: MOR106-7, GA_x6K02T2PMLR-6420220-6419279, MOR106-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258264
Homologene: 10652
Abhd12
Name: abhydrolase domain containing 12
Synonyms: 6330583M11Rik, 1500011G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76192
Homologene: 22910
Loxl4
Name: lysyl oxidase-like 4
Synonyms: 4833426I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67573
Homologene: 12977
Olfr849
Name: olfactory receptor 849
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258520
Homologene: 74179
Chil4
Name: chitinase-like 4
Synonyms: Ym2, Chi3l4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 104183
Homologene: 74931
Gm27742
Name: predicted gene, 27742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 59,551,240 bp
  • A to T, chromosome 1 at 90,807,614 bp
  • G to A, chromosome 1 at 178,915,426 bp
  • T to C, chromosome 2 at 22,915,505 bp
  • G to A, chromosome 2 at 40,611,434 bp
  • G to T, chromosome 2 at 76,876,467 bp
  • A to T, chromosome 2 at 86,347,237 bp
  • G to A, chromosome 2 at 150,839,722 bp
  • A to G, chromosome 2 at 170,418,627 bp
  • A to G, chromosome 3 at 35,789,558 bp
  • A to G, chromosome 3 at 35,800,565 bp
  • G to A, chromosome 3 at 94,387,193 bp
  • A to T, chromosome 3 at 102,165,781 bp
  • G to A, chromosome 3 at 106,203,727 bp
  • T to C, chromosome 3 at 116,746,630 bp
  • C to T, chromosome 4 at 6,271,205 bp
  • A to G, chromosome 4 at 135,226,039 bp
  • A to G, chromosome 4 at 147,512,693 bp
  • T to C, chromosome 5 at 30,355,713 bp
  • G to A, chromosome 5 at 88,664,156 bp
  • T to C, chromosome 5 at 120,766,089 bp
  • T to C, chromosome 5 at 123,293,810 bp
  • T to C, chromosome 5 at 135,961,924 bp
  • C to T, chromosome 6 at 124,703,224 bp
  • C to T, chromosome 6 at 125,165,234 bp
  • T to C, chromosome 7 at 25,726,812 bp
  • T to C, chromosome 7 at 28,836,012 bp
  • T to A, chromosome 7 at 80,351,739 bp
  • T to A, chromosome 7 at 105,693,954 bp
  • A to G, chromosome 7 at 122,994,735 bp
  • C to T, chromosome 8 at 71,491,467 bp
  • C to T, chromosome 9 at 19,441,735 bp
  • T to A, chromosome 11 at 53,702,005 bp
  • A to T, chromosome 12 at 13,231,503 bp
  • T to C, chromosome 12 at 26,477,047 bp
  • A to T, chromosome 12 at 101,893,768 bp
  • T to C, chromosome 14 at 33,382,220 bp
  • C to G, chromosome 14 at 50,681,050 bp
  • G to A, chromosome 14 at 55,503,955 bp
  • A to G, chromosome 15 at 6,580,923 bp
  • A to T, chromosome 15 at 82,617,285 bp
  • A to T, chromosome 15 at 98,908,720 bp
  • T to C, chromosome 17 at 32,367,985 bp
  • T to G, chromosome 17 at 34,709,454 bp
  • T to C, chromosome 18 at 6,111,734 bp
  • T to C, chromosome 18 at 63,124,730 bp
  • T to A, chromosome 19 at 42,607,591 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4181 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041017-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.