Strain Name:
C57BL/6J-MtgxR4190Btlr/Mmmh
Stock Number:
041021-MU
Citation ID:
RRID:MMRRC_041021-MU
Other Names:
R4190 (G1), C57BL/6J-MtgxR4190Btlr
Major Collection:

Gene Information

Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: TM7LN3, EGF-TM7, F4/80, DD7A5-7, Emr1, Ly71
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: BTF2, D5Ertd679e, 5033417D07Rik, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Synonyms: Gfrp, TR3, NP10, Hmr, GFRP1, NGFI-B, Nur77, TIS1, N10, Hbr1, Hbr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 15370
VEGA: 15
HGNC: HGNC:7980
Homologene: 1612
Srpk1
Name: serine/arginine-rich protein specific kinase 1
Synonyms: SR protein-specific kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20815
Homologene: 110962
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 2310007L05Rik, 4930538C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 75826
VEGA: 16
Homologene: 11005
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: ATFa-associated Modulator, 2610204M12Rik, Mcaf1, AM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54343
Homologene: 10051
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, jdf2, D7H15F37S1, rjs, D15F32S1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Yars
Name: tyrosyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 107271
Homologene: 2730
Cdc42bpg
Name: CDC42 binding protein kinase gamma (DMPK-like)
Synonyms: MRCKgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240505
Homologene: 28384
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Trmt44
Name: tRNA methyltransferase 44
Synonyms: 2310079F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 78890
Homologene: 12708
Fam185a
Name: family with sequence similarity 185, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330050
Homologene: 51828
Vit
Name: vitrin
Synonyms: 1700110E08Rik, akhirin, 1700052E02Rik, AKH, 2810429K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74199
VEGA: 17
Homologene: 24942
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Nlgn1
Name: neuroligin 1
Synonyms: Nlg1, NL1, 6330415N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192167
Homologene: 56690
Gabra2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
Synonyms: Gabra-2, C630048P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14395
HGNC: HGNC:4076
Homologene: 20217
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93705
Homologene: 81868
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 192188
Homologene: 23022
Ctse
Name: cathepsin E
Synonyms: A430072O03Rik, C920004C08Rik, CE, CatE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 625068
Homologene: 129606
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 210274
Homologene: 105965
Olfr1261
Name: olfactory receptor 1261
Synonyms: GA_x6K02T2Q125-51425355-51426275, MOR234-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258466
Homologene: 138310
Prodh
Name: proline dehydrogenase
Synonyms: Pro1, Pro-1, Ym24d07
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19125
HGNC: HGNC:9453
Homologene: 40764
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 80902
Homologene: 68317
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106763
VEGA: 17
Homologene: 50342
Fam234a
Name: family with sequence similarity 234, member A
Synonyms: Itfg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106581
Homologene: 12932
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233315
Homologene: 9822
Ankrd13b
Name: ankyrin repeat domain 13b
Synonyms: B930093C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268445
Homologene: 27367
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 625131
Homologene: 129606
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66673
VEGA: 19
Homologene: 8986
Olfr820
Name: olfactory receptor 820
Synonyms: GA_x6K02T2PULF-11688441-11689379, MOR116-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258670
Homologene: 17337
Ddx19b
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
Synonyms: 2810457M08Rik, 4921519L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234733
HGNC: HGNC:2742
Homologene: 56032
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ifi75, Ipr1, 5031415C07Rik, 5830484A20Rik, 52kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
C230029F24Rik
Name: RIKEN cDNA C230029F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 442837
Dipk1b
Name: divergent protein kinase domain 1B
Synonyms: Fam69b, PIP49, B230317C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56279
Homologene: 10516
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71718
Homologene: 41107
Olfr770
Name: olfactory receptor 770
Synonyms: MOR114-5, GA_x6K02T2PULF-10819232-10818297
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258862
Homologene: 27285
Olfr488
Name: olfactory receptor 488
Synonyms: GA_x6K02T2PBJ9-10586187-10585243, MOR204-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258727
Homologene: 110483
Trav6-1
Name: T cell receptor alpha variable 6-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 667449
Fahd2a
Name: fumarylacetoacetate hydrolase domain containing 2A
Synonyms: B430104H02Rik, 1500003K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68126
Homologene: 131290
Mir7071
Name: microRNA 7071
Synonyms: mmu-mir-7071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102465649
VEGA: 8
Plscr5
Name: phospholipid scramblase family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100504689
Homologene: 28688
Ppp2r3d
Name: protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta
Synonyms: Ppp2r3a, PR59, Ppp2r3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
4732463B04Rik
Name: RIKEN cDNA 4732463B04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • AGAAAG to A, chromosome 1 at 49,310,929 bp
  • C to G, chromosome 1 at 85,589,118 bp
  • T to A, chromosome 1 at 131,662,741 bp
  • T to C, chromosome 2 at 26,636,181 bp
  • C to A, chromosome 2 at 89,993,574 bp
  • C to T, chromosome 2 at 127,438,566 bp
  • T to A, chromosome 3 at 25,433,898 bp
  • A to G, chromosome 4 at 123,473,042 bp
  • T to A, chromosome 4 at 129,200,027 bp
  • T to A, chromosome 5 at 21,425,124 bp
  • C to A, chromosome 5 at 35,574,970 bp
  • G to A, chromosome 5 at 71,007,998 bp
  • G to A, chromosome 5 at 124,594,786 bp
  • T to A, chromosome 6 at 3,717,106 bp
  • T to C, chromosome 6 at 136,587,501 bp
  • T to C, chromosome 7 at 56,122,448 bp
  • G to T, chromosome 7 at 64,314,186 bp
  • T to C, chromosome 7 at 108,256,123 bp
  • G to A, chromosome 7 at 144,411,314 bp
  • T to C, chromosome 8 at 88,138,260 bp
  • A to T, chromosome 8 at 111,011,348 bp
  • T to C, chromosome 9 at 40,211,337 bp
  • T to A, chromosome 9 at 62,732,109 bp
  • T to C, chromosome 9 at 92,198,598 bp
  • T to C, chromosome 9 at 124,424,123 bp
  • A to G, chromosome 10 at 27,266,664 bp
  • G to T, chromosome 10 at 86,878,944 bp
  • T to C, chromosome 10 at 92,885,023 bp
  • T to C, chromosome 10 at 129,132,967 bp
  • A to T, chromosome 10 at 130,017,978 bp
  • A to T, chromosome 10 at 130,391,294 bp
  • A to G, chromosome 10 at 130,472,687 bp
  • G to A, chromosome 11 at 77,476,375 bp
  • T to C, chromosome 12 at 84,043,174 bp
  • A to G, chromosome 14 at 52,638,519 bp
  • T to C, chromosome 15 at 101,274,112 bp
  • C to T, chromosome 16 at 18,073,640 bp
  • G to T, chromosome 16 at 22,046,667 bp
  • T to C, chromosome 17 at 25,102,013 bp
  • A to T, chromosome 17 at 26,213,860 bp
  • G to A, chromosome 17 at 28,600,451 bp
  • A to T, chromosome 17 at 46,479,247 bp
  • A to G, chromosome 17 at 57,402,811 bp
  • A to G, chromosome 17 at 78,586,826 bp
  • G to C, chromosome 18 at 37,763,541 bp
  • T to C, chromosome 19 at 6,321,681 bp
  • T to C, chromosome 19 at 48,749,373 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4190 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041021-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.