Strain Name:
C57BL/6J-MtgxR4195Btlr/Mmmh
Stock Number:
041026-MU
Citation ID:
RRID:MMRRC_041026-MU
Other Names:
R4195 (G1), C57BL/6J-MtgxR4195Btlr
Major Collection:

Gene Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: b2b1562Clo, my, 8430406N05Rik, 6030440P17Rik, ne
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Atl3
Name: atlastin GTPase 3
Synonyms: 4633402C03Rik, 5730596K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Ggap1, Centg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 347722
Homologene: 56689
Apod
Name: apolipoprotein D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11815
HGNC: HGNC:612
Homologene: 1246
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: Aloxe2, 12R-LOX, e-LOX2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Cse1l
Name: chromosome segregation 1-like (S. cerevisiae)
Synonyms: 2610100P18Rik, Cas, Xpo2, Capts
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110750
HGNC: HGNC:2431
Homologene: 1006
Eif4enif1
Name: eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms: D11Ertd166e, Clast4, A930019J01Rik, 2610509L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74203
Homologene: 10522
G3bp2
Name: GTPase activating protein (SH3 domain) binding protein 2
Synonyms: G3BP2, E430034L04Rik, G3BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23881
Homologene: 137244
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 6430567E01Rik, 3110065C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108946
Homologene: 9182
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
Tas1r3
Name: taste receptor, type 1, member 3
Synonyms: T1r3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 83771
Homologene: 12890
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 101056073
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Slc30a4
Name: solute carrier family 30 (zinc transporter), member 4
Synonyms: Znt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22785
Homologene: 74984
Fbll1
Name: fibrillarin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237730
Homologene: 28185
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: Gm628, LOC268816
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268816
Gm281
Name: predicted gene 281
Synonyms: LOC238939
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238939
Homologene: 141164
Lman2l
Name: lectin, mannose-binding 2-like
Synonyms: A630028F14Rik, VIP36-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214895
Homologene: 57125
Polr1e
Name: polymerase (RNA) I polypeptide E
Synonyms: 53kDa, Praf1, D030019D19Rik, Paf53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64424
Homologene: 41486
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Actg2
Name: actin, gamma 2, smooth muscle, enteric
Synonyms: SMGA, Acta3, Act-4, Act4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11468
HGNC: HGNC:145
Homologene: 123845
Rasgef1c
Name: RasGEF domain family, member 1C
Synonyms: 9130006A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74563
Homologene: 17918
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Cnnm4
Name: cyclin M4
Synonyms: 5430430O18Rik, Acdp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94220
HGNC: HGNC:105
Homologene: 75662
Acmsd
Name: amino carboxymuconate semialdehyde decarboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 266645
Homologene: 44520
Olfr266
Name: olfactory receptor 266
Synonyms: MOR122-2, GA_x6K02T2N6GK-529983-529033
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 258482
Homologene: 51728
Mrps9
Name: mitochondrial ribosomal protein S9
Synonyms: 2310002A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69527
Homologene: 32565
Cacna1f
Name: calcium channel, voltage-dependent, alpha 1F subunit
Synonyms: Sfc17, Cav1.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54652
HGNC: HGNC:1393
Homologene: 74542
Nmi
Name: N-myc (and STAT) interactor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64685
HGNC: HGNC:7854
Homologene: 3441
Cldn9
Name: claudin 9
Synonyms: nmf329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56863
HGNC: HGNC:2051
Homologene: 10656
Gm17690
Name: predicted gene, 17690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm2396
Name: predicted gene 2396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 105245043
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 24,534,052 bp
  • A to C, chromosome 1 at 36,424,941 bp
  • C to A, chromosome 1 at 36,499,508 bp
  • T to G, chromosome 1 at 42,901,094 bp
  • A to G, chromosome 1 at 89,834,539 bp
  • T to G, chromosome 1 at 127,749,194 bp
  • T to C, chromosome 2 at 10,115,285 bp
  • A to C, chromosome 2 at 51,948,620 bp
  • G to T, chromosome 2 at 52,271,559 bp
  • A to T, chromosome 2 at 52,290,835 bp
  • G to A, chromosome 2 at 122,685,270 bp
  • C to A, chromosome 2 at 130,933,412 bp
  • A to G, chromosome 2 at 166,929,979 bp
  • A to G, chromosome 3 at 53,539,268 bp
  • T to C, chromosome 3 at 96,167,891 bp
  • A to T, chromosome 3 at 106,822,012 bp
  • A to G, chromosome 3 at 152,428,465 bp
  • T to C, chromosome 4 at 45,019,327 bp
  • A to T, chromosome 4 at 145,536,977 bp
  • T to C, chromosome 4 at 155,862,985 bp
  • A to G, chromosome 5 at 14,677,563 bp
  • A to G, chromosome 5 at 92,055,416 bp
  • T to G, chromosome 6 at 83,523,173 bp
  • A to G, chromosome 9 at 88,917,662 bp
  • T to C, chromosome 11 at 3,243,186 bp
  • T to A, chromosome 11 at 8,909,929 bp
  • A to G, chromosome 11 at 35,797,666 bp
  • T to A, chromosome 11 at 35,797,872 bp
  • C to T, chromosome 11 at 49,971,455 bp
  • A to G, chromosome 11 at 69,169,600 bp
  • C to A, chromosome 14 at 13,829,772 bp
  • C to T, chromosome 15 at 73,836,243 bp
  • T to C, chromosome 16 at 31,297,574 bp
  • G to A, chromosome 17 at 7,758,526 bp
  • T to C, chromosome 17 at 23,683,174 bp
  • A to G, chromosome 19 at 7,518,546 bp
  • A to G, chromosome X at 7,608,930 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4195 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041026-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.