Strain Name:
C57BL/6J-MtgxR4208Btlr/Mmmh
Stock Number:
041037-MU
Citation ID:
RRID:MMRRC_041037-MU
Other Names:
R4208 (G1), C57BL/6J-MtgxR4208Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Sstr2
Name: somatostatin receptor 2
Synonyms: SSTR-2, sst2, Smstr2, Smstr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20606
Homologene: 37427
Lars
Name: leucyl-tRNA synthetase
Synonyms: 3110009L02Rik, 2310045K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75420
Homologene: 11415
Ldlrad3
Name: low density lipoprotein receptor class A domain containing 3
Synonyms: Lrad3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241576
Homologene: 18377
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D330030P06Rik, D2Wsu23e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353282
Homologene: 82485
Gabpb2
Name: GA repeat binding protein, beta 2
Synonyms: 9430006E19Rik, Gabpb2-1, A430024B14Rik, 1810015F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213054
Homologene: 34921
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228790
Homologene: 9098
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Click-II, Dcamkl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70762
Homologene: 69431
Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms: 2810028N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72662
VEGA: 14
Homologene: 6910
Casp12
Name: caspase 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12364
Homologene: 7654
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
H3f3a
Name: H3.3 histone A
Synonyms: H3.3A, H3-3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15078
HGNC: HGNC:4764
Homologene: 134170
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Ace2
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Synonyms: 2010305L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 70008
Homologene: 41448
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Kif3b
Name: kinesin family member 3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16569
HGNC: HGNC:6320
Homologene: 55849
Lsr
Name: lipolysis stimulated lipoprotein receptor
Synonyms: Lisch7, ILDR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54135
Homologene: 9306
Me2
Name: malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms: D030040L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107029
VEGA: 18
HGNC: HGNC:6984
Homologene: 37615
Tamm41
Name: TAM41 mitochondrial translocator assembly and maintenance homolog
Synonyms: 1500001M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68971
Homologene: 13754
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106205
Homologene: 8563
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Lingo2
Name: leucine rich repeat and Ig domain containing 2
Synonyms: B230217C06Rik, Lrrn6c, LERN3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242384
Homologene: 17621
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
B4galnt3
Name: beta-1,4-N-acetyl-galactosaminyl transferase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330406
Homologene: 18328
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171261
Homologene: 134023
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72303
Homologene: 133566
A1cf
Name: APOBEC1 complementation factor
Synonyms: apobec-1 complementation factor, ACF, 1810073H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Ino80b
Name: INO80 complex subunit B
Synonyms: Papa1, HMG1YL4, 2510009I23Rik, Hmga1l4, Znhit4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70020
Homologene: 32566
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117167
Homologene: 36422
Ctnna3
Name: catenin (cadherin associated protein), alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Or52n3
Name: olfactory receptor family 52 subfamily N member 3
Synonyms: GA_x6K02T2PBJ9-7509539-7510489, MOR34-7, Olfr665
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258810
Homologene: 110477
Pfkfb1
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Synonyms: PFK-2/FBPase-2 gene A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 18639
HGNC: HGNC:8872
Homologene: 105654
Apol9a
Name: apolipoprotein L 9a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223672
VEGA: 15
Homologene: 77567
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Padi1
Name: peptidyl arginine deiminase, type I
Synonyms: Pdi1, Pad type 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18599
Homologene: 7881
Rnase4
Name: ribonuclease, RNase A family 4
Synonyms: C730049F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58809
VEGA: 14
Homologene: 10576
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50702
Homologene: 55632
Or4c1
Name: olfactory receptor family 4 subfamily C member 1
Synonyms: GA_x6K02T2Q125-50748233-50747292, MOR235-2, Olfr1231
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258446
Homologene: 27168
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67370
Homologene: 23514
Efhc2
Name: EF-hand domain (C-terminal) containing 2
Synonyms: 4933407D04Rik, mRib72-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 74405
Homologene: 11863
Trav7-3
Name: T cell receptor alpha variable 7-3
Synonyms: Gm13946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 547420
RP24-126A19.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Trbv23
Name: T cell receptor beta, variable V23
Synonyms: VB20, Tcrb-V20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124688
Gm7293
Name: predicted gene 7293
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 640374
VEGA: 9
Fam181a
Name: family with sequence similarity 181, member A
Synonyms: EG544888
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100504156
Homologene: 34701
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 139,516,341 bp
  • A to G, chromosome 1 at 139,547,878 bp
  • C to T, chromosome 1 at 180,803,138 bp
  • T to A, chromosome 2 at 10,542,982 bp
  • A to T, chromosome 2 at 89,302,926 bp
  • C to T, chromosome 2 at 101,953,162 bp
  • G to A, chromosome 2 at 153,323,557 bp
  • T to C, chromosome 2 at 153,393,434 bp
  • T to A, chromosome 2 at 178,355,040 bp
  • T to A, chromosome 3 at 73,051,157 bp
  • A to G, chromosome 3 at 86,830,822 bp
  • A to G, chromosome 3 at 95,203,934 bp
  • T to C, chromosome 4 at 35,709,810 bp
  • C to A, chromosome 4 at 140,817,227 bp
  • A to G, chromosome 5 at 7,980,404 bp
  • C to A, chromosome 5 at 146,895,796 bp
  • T to C, chromosome 6 at 17,548,729 bp
  • A to T, chromosome 6 at 41,216,088 bp
  • A to T, chromosome 6 at 48,931,647 bp
  • G to C, chromosome 6 at 83,122,333 bp
  • AGGG to AGG, chromosome 6 at 115,012,359 bp
  • A to G, chromosome 6 at 120,215,102 bp
  • G to A, chromosome 7 at 12,494,175 bp
  • A to G, chromosome 7 at 13,132,258 bp
  • A to G, chromosome 7 at 30,973,094 bp
  • A to C, chromosome 7 at 45,986,563 bp
  • A to G, chromosome 7 at 104,881,603 bp
  • T to C, chromosome 9 at 5,346,629 bp
  • C to T, chromosome 9 at 8,100,821 bp
  • A to G, chromosome 9 at 51,623,579 bp
  • T to A, chromosome 9 at 119,616,776 bp
  • C to T, chromosome 10 at 34,395,543 bp
  • T to A, chromosome 10 at 64,959,778 bp
  • T to C, chromosome 11 at 102,000,600 bp
  • G to A, chromosome 11 at 109,981,725 bp
  • A to C, chromosome 11 at 113,624,656 bp
  • A to G, chromosome 12 at 103,315,914 bp
  • A to G, chromosome 13 at 24,417,427 bp
  • A to G, chromosome 13 at 51,655,131 bp
  • A to G, chromosome 14 at 51,105,005 bp
  • A to G, chromosome 14 at 53,443,746 bp
  • T to G, chromosome 14 at 99,095,316 bp
  • A to G, chromosome 15 at 11,071,754 bp
  • G to C, chromosome 15 at 77,404,396 bp
  • C to T, chromosome 16 at 11,164,644 bp
  • C to T, chromosome 17 at 57,205,303 bp
  • T to C, chromosome 18 at 42,229,703 bp
  • T to C, chromosome 18 at 73,791,085 bp
  • T to C, chromosome 19 at 31,932,660 bp
  • T to C, chromosome 19 at 39,090,655 bp
  • T to C, chromosome X at 17,230,550 bp
  • A to T, chromosome X at 150,622,188 bp
  • A to G, chromosome X at 164,169,585 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4208 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041037-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.