Strain Name:
C57BL/6J-MtgxR4214Btlr/Mmmh
Stock Number:
041041-MU
Citation ID:
RRID:MMRRC_041041-MU
Other Names:
R4214 (G1), C57BL/6J-MtgxR4214Btlr
Major Collection:

Gene Information

Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Drd2
Name: dopamine receptor D2
Synonyms: Drd-2, D2R, D2 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Cadm1
Name: cell adhesion molecule 1
Synonyms: Igsf4a, Igsf4, SgIGSF, Tslc1, RA175N, RA175C, RA175B, RA175A, Necl2, 2900073G06Rik, 3100001I08Rik, SynCam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54725
HGNC: HGNC:5951
Homologene: 8641
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224656
Homologene: 2569
Nrep
Name: neuronal regeneration related protein
Synonyms: PTZ17, D0H4S114, P311, SEZ17, Sez17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27528
VEGA: 18
Homologene: 70874
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ano6
Name: anoctamin 6
Synonyms: Tmem16f, 2900059G15Rik, F730003B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: KMT6, Enx1h, Enx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Ift80
Name: intraflagellar transport 80
Synonyms: Wdr56, 4921524P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68259
Homologene: 12253
Gm14393
Name: predicted gene 14393
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 664987
Mmadhc
Name: methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
Synonyms: 2010311D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109129
Homologene: 9248
Pfkp
Name: phosphofructokinase, platelet
Synonyms: 9330125N24Rik, PFK-C, 1200015H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216177
Homologene: 87560
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237553
Homologene: 75007
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ccr7
Name: chemokine (C-C motif) receptor 7
Synonyms: CD197, Cmkbr7, Ebi1h, EBI1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Vmn1r213
Name: vomeronasal 1 receptor 213
Synonyms: V1rh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171249
Homologene: 110880
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, RASSF4, 2010003K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Plcl1
Name: phospholipase C-like 1
Synonyms: C230017K02Rik, PRIP-1, PLC-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, Egfl4, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241116
Homologene: 28093
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: 2600017P15Rik, C630012L17Rik, NPD002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229211
Homologene: 8539
Osgepl1
Name: O-sialoglycoprotein endopeptidase-like 1
Synonyms: MGC13061, 2610001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72085
Homologene: 5561
Gm15759
Name: predicted gene 15759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636191
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76365
Homologene: 11384
Olfr291
Name: olfactory receptor 291
Synonyms: GA_x6K02T2NHDJ-11231385-11230438, MOR254-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258410
Homologene: 83130
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71872
Homologene: 70273
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102747
Homologene: 9782
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: PGDH, 3PGDH, 3-PGDH, A10, PGAD, SERA, PGD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Polr3k
Name: polymerase (RNA) III (DNA directed) polypeptide K
Synonyms: 12.3kDa, C11, RPC11, 1500004O14Rik, RPC10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67005
Homologene: 5610
Erich5
Name: glutamate rich 5
Synonyms: BC030476
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239368
VEGA: 15
Homologene: 52129
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: Catsperg, A230107C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320225
Homologene: 10915
Themis3
Name: thymocyte selection associated family member 3
Synonyms: 9130404H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74556
Homologene: 137389
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 1700071K18Rik, 2310044E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76612
Homologene: 19268
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Plscr2
Name: phospholipid scramblase 2
Synonyms: PL scramblase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18828
Homologene: 134152
Adamts5
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC-76, UNC76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Ceacam5
Name: carcinoembryonic antigen-related cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73250
Homologene: 115938
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49f, Ly49F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16637
Homologene: 110821
Bco2
Name: beta-carotene oxygenase 2
Synonyms: beta-diox-II, B-diox-II, Bcmo2, Bcdo2, CMO2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170752
Homologene: 12912
Gpr162
Name: G protein-coupled receptor 162
Synonyms: A-2, Grca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14788
Homologene: 8400
Gm7367
Name: predicted pseudogene 7367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 664849
A730013G03Rik
Name: RIKEN cDNA A730013G03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320952
Atp2b3
Name: ATPase, Ca++ transporting, plasma membrane 3
Synonyms: Pmca3, 6430519O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320707
HGNC: HGNC:816
Homologene: 123775
Rcvrn
Name: recoverin
Synonyms: cancer associated retinopathy protein, S-modulin, guanylate cyclase activator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19674
HGNC: HGNC:9937
Homologene: 2177
Msl3
Name: MSL complex subunit 3
Synonyms: Msl3l1, Msl31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17692
HGNC: HGNC:7370
Homologene: 40749
RP24-150H14.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Malsu1
Name: mitochondrial assembly of ribosomal large subunit 1
Synonyms: 2410003K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75593
Homologene: 16317
Gm5329
Name: predicted gene 5329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102633076
Folr2
Name: folate receptor 2 (fetal)
Synonyms: FBP2, Folbp2, Folbp-2, FR-P3, Folbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14276
HGNC: HGNC:3793
Homologene: 627
9430091E24Rik
Name: RIKEN cDNA 9430091E24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434350
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,101,159 bp
  • A to G, chromosome 1 at 11,285,061 bp
  • A to G, chromosome 1 at 53,315,008 bp
  • C to T, chromosome 1 at 55,751,335 bp
  • T to A, chromosome 1 at 58,221,892 bp
  • T to C, chromosome 1 at 58,307,444 bp
  • T to A, chromosome 1 at 71,288,697 bp
  • T to A, chromosome 1 at 74,927,681 bp
  • T to A, chromosome 1 at 185,345,429 bp
  • C to T, chromosome 1 at 192,833,537 bp
  • T to C, chromosome 2 at 50,291,332 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • C to T, chromosome 2 at 175,061,847 bp
  • A to T, chromosome 2 at 181,868,242 bp
  • A to G, chromosome 3 at 36,073,603 bp
  • A to T, chromosome 3 at 68,990,808 bp
  • A to T, chromosome 3 at 98,328,061 bp
  • A to C, chromosome 6 at 47,533,814 bp
  • C to T, chromosome 6 at 49,082,904 bp
  • A to T, chromosome 6 at 124,860,068 bp
  • T to G, chromosome 6 at 130,018,922 bp
  • T to A, chromosome 7 at 17,752,151 bp
  • T to A, chromosome 7 at 25,355,368 bp
  • T to C, chromosome 7 at 29,195,932 bp
  • T to G, chromosome 7 at 31,972,403 bp
  • A to G, chromosome 7 at 60,155,769 bp
  • C to T, chromosome 7 at 84,857,289 bp
  • T to G, chromosome 7 at 101,843,699 bp
  • C to T, chromosome 7 at 139,223,693 bp
  • A to G, chromosome 8 at 111,129,580 bp
  • A to G, chromosome 9 at 36,870,488 bp
  • A to G, chromosome 9 at 47,797,443 bp
  • A to G, chromosome 9 at 49,404,921 bp
  • A to G, chromosome 9 at 50,545,366 bp
  • G to A, chromosome 9 at 60,666,326 bp
  • G to A, chromosome 9 at 86,489,641 bp
  • T to C, chromosome 9 at 87,724,465 bp
  • A to G, chromosome 9 at 92,287,737 bp
  • A to G, chromosome 10 at 82,151,389 bp
  • A to T, chromosome 10 at 114,788,070 bp
  • T to C, chromosome 10 at 123,016,492 bp
  • G to T, chromosome 10 at 127,665,048 bp
  • A to T, chromosome 11 at 9,293,877 bp
  • A to T, chromosome 11 at 67,695,688 bp
  • T to C, chromosome 11 at 99,145,046 bp
  • A to G, chromosome 13 at 6,619,225 bp
  • G to A, chromosome 13 at 23,012,003 bp
  • C to T, chromosome 15 at 34,471,411 bp
  • A to G, chromosome 15 at 39,872,580 bp
  • A to C, chromosome 15 at 95,965,909 bp
  • T to A, chromosome 16 at 24,762,054 bp
  • G to A, chromosome 16 at 85,868,643 bp
  • T to C, chromosome 17 at 28,201,029 bp
  • T to C, chromosome 17 at 32,132,207 bp
  • T to C, chromosome 17 at 66,560,017 bp
  • G to T, chromosome 18 at 33,464,477 bp
  • T to C, chromosome 19 at 15,959,579 bp
  • A to G, chromosome X at 73,570,315 bp
  • A to T, chromosome X at 168,662,434 bp
  • A to G, chromosome X at 168,667,063 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4214 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041041-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.