Strain Name:
C57BL/6J-MtgxR4230Btlr/Mmmh
Stock Number:
041049-MU
Citation ID:
RRID:MMRRC_041049-MU
Other Names:
R4230 (G1), C57BL/6J-MtgxR4230Btlr
Major Collection:

Gene Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Jam2
Name: junction adhesion molecule 2
Synonyms: 2410030G21Rik, Jcam2, 2410167M24Rik, JAM-2, VE-JAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67374
Homologene: 10929
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 211329
VEGA: 10
Homologene: 65245
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71521
Homologene: 22877
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: SFA66, Sap62, 66kDa, PRP11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20222
Homologene: 133823
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67542
Homologene: 10802
Kcnk5
Name: potassium channel, subfamily K, member 5
Synonyms: TASK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16529
VEGA: 14
HGNC: HGNC:6280
Homologene: 2773
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, GAPIII activator 3, hlb381, GAPIII, Ras GTPase-activating protein III, scat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 19414
Homologene: 7217
Itln1
Name: intelectin 1 (galactofuranose binding)
Synonyms: Itln2, Itlna, mLfR, IntL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16429
Homologene: 111044
Sec61a1
Name: Sec61 alpha 1 subunit (S. cerevisiae)
Synonyms: Sec61a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 53421
Homologene: 55537
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232339
Homologene: 45968
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99683
Homologene: 55968
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Urod
Name: uroporphyrinogen decarboxylase
Synonyms: Uro-d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22275
Homologene: 320
Tgm5
Name: transglutaminase 5
Synonyms: TGx, 2310007C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74176
Homologene: 20899
Slc46a2
Name: solute carrier family 46, member 2
Synonyms: 5430429N04Rik, Tscot, TSO-1C12, Ly110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 30936
Homologene: 23273
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70083
VEGA: 17
Homologene: 11432
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56079
Homologene: 77850
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 100125586
HGNC: null
Homologene: 129753
Phf11c
Name: PHD finger protein 11C
Synonyms: Gm6907
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 628705
Homologene: 87807
Atxn7
Name: ataxin 7
Synonyms: Sca7, A430107N12Rik, ataxin-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 246103
VEGA: 14
Homologene: 30967
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244871
VEGA: 9
Homologene: 35462
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219189
VEGA: 14
Homologene: 44881
Olfr1281
Name: olfactory receptor 1281
Synonyms: MOR248-14P, MOR248-18, GA_x6K02T2Q125-72379864-72380781
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257979
HGNC: null
Homologene: 73992
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: BC048546, Ovos2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232400
HGNC: null
Homologene: 45969
Olfr670
Name: olfactory receptor 670
Synonyms: MOR32-8, GA_x6K02T2PBJ9-7589577-7588639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384703
HGNC: null
Homologene: 105163
Hltf
Name: helicase-like transcription factor
Synonyms: Snf2l3, P113, Smarca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20585
Homologene: 30136
Tmem229a
Name: transmembrane protein 229A
Synonyms: 6332401O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 319832
Homologene: 85312
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243369
Homologene: 45453
Apbb1
Name: amyloid beta (A4) precursor protein-binding, family B, member 1
Synonyms: Rir, Fe65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Slc45a3
Name: solute carrier family 45, member 3
Synonyms: 2210413P12Rik, Pcanap6, IPCA-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 212980
HGNC: HGNC:8642
Homologene: 23813
Ccdc189
Name: coiled-coil domain containing 189
Synonyms: LOC233899, Gm166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233899
Homologene: 79950
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268465
Homologene: 16123
Olfr134
Name: olfactory receptor 134
Synonyms: GA_x6K02T2PSCP-2623613-2624551, MOR256-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258829
HGNC: null
Homologene: 110603
Alg11
Name: asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 207958
Homologene: 68893
Spag6l
Name: sperm associated antigen 6-like
Synonyms: PF16, Spag6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 50525
Homologene: 8252
Fam178b
Name: family with sequence similarity 178, member B
Synonyms: 1700024G10Rik, LOC381337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381337
Homologene: 87288
Dppa3
Name: developmental pluripotency-associated 3
Synonyms: stella, 2410075G02Rik, PGC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73708
Homologene: 138189
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244853
VEGA: 9
Homologene: 83471
Ifi44l
Name: interferon-induced protein 44 like
Synonyms: NS1178, H28, H-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 15061
Homologene: 48468
Olfr373
Name: olfactory receptor 373
Synonyms: GA_x6K02T2NUPS-231686-232630, MOR282-2, MOR282-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 258532
Homologene: 17287
Vmn1r223
Name: vomeronasal 1 receptor 223
Synonyms: Gm11330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 100036518
HGNC: null
Homologene: 110880
Onecut3
Name: one cut domain, family member 3
Synonyms: OC-3, Oc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 246086
Homologene: 82258
Spi1
Name: spleen focus forming virus (SFFV) proviral integration oncogene
Synonyms: Sfpi-1, Tfpu.1, PU.1, Tcfpu1, Dis-1, Spi-1, Sfpi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20375
Homologene: 2346
Gm16638
Name: predicted gene, 16638
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 102631889
HGNC: null
Homologene: null
Gm15881
Name: predicted gene 15881
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 100271928
HGNC: null
Homologene: null
Gm10735
Name: predicted gene 10735
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Gm25683
Name: predicted gene, 25683
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Gm2035
Name: predicted pseudogene 2035
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 100039076
VEGA: 12
HGNC: null
Homologene: null
Spag6
Name: sperm associated antigen 6
Synonyms: BC061194, Spag6l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381350
Homologene: 133723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,564,399 bp
  • T to A, chromosome 1 at 131,981,661 bp
  • G to A, chromosome 1 at 171,534,807 bp
  • T to A, chromosome 2 at 18,715,638 bp
  • T to C, chromosome 2 at 76,724,120 bp
  • T to C, chromosome 2 at 91,115,335 bp
  • T to G, chromosome 2 at 111,329,130 bp
  • T to C, chromosome 2 at 121,070,735 bp
  • T to C, chromosome 3 at 20,108,193 bp
  • T to C, chromosome 3 at 52,992,808 bp
  • T to A, chromosome 3 at 64,134,491 bp
  • G to T, chromosome 3 at 130,040,719 bp
  • A to T, chromosome 3 at 151,762,877 bp
  • T to C, chromosome 4 at 59,914,048 bp
  • T to G, chromosome 4 at 65,911,682 bp
  • T to A, chromosome 4 at 116,992,683 bp
  • A to G, chromosome 5 at 65,629,986 bp
  • T to A, chromosome 6 at 24,954,832 bp
  • T to C, chromosome 6 at 48,490,934 bp
  • A to T, chromosome 6 at 88,515,431 bp
  • G to C, chromosome 6 at 118,559,388 bp
  • A to T, chromosome 6 at 122,629,332 bp
  • C to T, chromosome 6 at 128,580,386 bp
  • T to C, chromosome 7 at 83,597,402 bp
  • A to T, chromosome 7 at 104,960,594 bp
  • T to C, chromosome 7 at 105,567,684 bp
  • C to T, chromosome 7 at 118,148,733 bp
  • T to A, chromosome 7 at 127,586,830 bp
  • T to A, chromosome 7 at 141,863,522 bp
  • A to G, chromosome 8 at 13,570,264 bp
  • T to A, chromosome 8 at 22,065,518 bp
  • T to C, chromosome 8 at 58,700,184 bp
  • T to C, chromosome 8 at 72,100,344 bp
  • T to C, chromosome 9 at 32,257,474 bp
  • A to G, chromosome 9 at 48,392,822 bp
  • T to A, chromosome 9 at 52,144,428 bp
  • A to T, chromosome 10 at 30,698,257 bp
  • T to C, chromosome 10 at 80,513,959 bp
  • T to C, chromosome 10 at 80,803,660 bp
  • G to A, chromosome 11 at 94,647,992 bp
  • A to T, chromosome 12 at 87,919,797 bp
  • A to T, chromosome 13 at 23,249,415 bp
  • T to C, chromosome 13 at 113,041,209 bp
  • T to A, chromosome 14 at 12,488,987 bp
  • G to A, chromosome 14 at 14,100,381 bp
  • C to A, chromosome 14 at 20,144,784 bp
  • A to T, chromosome 14 at 59,393,067 bp
  • C to T, chromosome 14 at 79,082,852 bp
  • T to A, chromosome 16 at 84,821,292 bp
  • T to C, chromosome 17 at 25,387,863 bp
  • A to G, chromosome 17 at 25,796,941 bp
  • A to C, chromosome 17 at 38,175,881 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4230 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041049-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.