Strain Name:
C57BL/6J-MtgxR4235Btlr/Mmmh
Stock Number:
041052-MU
Citation ID:
RRID:MMRRC_041052-MU
Other Names:
R4235 (G1), C57BL/6J-MtgxR4235Btlr
Major Collection:

Gene Information

Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74996
Homologene: 9929
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233833
Homologene: 41399
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Tyw5
Name: tRNA-yW synthesizing protein 5
Synonyms: 1110034B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68736
Homologene: 72085
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71435
Homologene: 10822
Bnc2
Name: basonuclin 2
Synonyms: 5031434M05Rik, 8430420F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242509
Homologene: 18243
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21848
Homologene: 20830
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Cc2d1b
Name: coiled-coil and C2 domain containing 1B
Synonyms: A830039B04Rik, Freud2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319965
Homologene: 70951
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: A630023E24Rik, 7330410C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64706
Homologene: 11224
Mcpt1
Name: mast cell protease 1
Synonyms: Mcp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17224
VEGA: 14
Homologene: 137209
Limk1
Name: LIM-domain containing, protein kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16885
HGNC: HGNC:6613
Homologene: 1738
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Ogt
Name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Synonyms: OGT, 1110038P24Rik, 4831420N21Rik, Ogtl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 108155
HGNC: HGNC:8127
Homologene: 9675
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Cxxc8, Fbl7, lalina, Jhdm1a, Fbxl11, Gm4560, 5530401A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225876
Homologene: 56564
Hspa12b
Name: heat shock protein 12B
Synonyms: 2700081N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72630
Homologene: 41749
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, SPACR, A930015H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pydc3, Pyr-rv1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Pramel25
Name: PRAME like 25
Synonyms: MGC:91194, Gm13023
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194227
Homologene: 103830
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, D430008P04Rik, tie-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21846
Homologene: 3957
Sobp
Name: sine oculis binding protein
Synonyms: 2900009C16Rik, 5330439J01Rik, Jxc1, jc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109205
Homologene: 41216
Mamdc2
Name: MAM domain containing 2
Synonyms: 1200015L10Rik, mamcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71738
VEGA: 19
Homologene: 17722
Olfr679
Name: olfactory receptor 679
Synonyms: GA_x6K02T2PBJ9-7714499-7715446, MOR40-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259046
Homologene: 81538
Tmem266
Name: transmembrane protein 266
Synonyms: AI118078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244886
Homologene: 17551
Rsl1
Name: regulator of sex limited protein 1
Synonyms: rslcan-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380855
Homologene: 110878
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: CD107a, Lamp-1, Perk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16783
HGNC: HGNC:6499
Homologene: 4061
Tnfaip6
Name: tumor necrosis factor alpha induced protein 6
Synonyms: Tsg6, Tnfip6, TSG-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21930
Homologene: 5162
Nxt1
Name: NTF2-related export protein 1
Synonyms: 1110001N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56488
Homologene: 8301
Nfil3
Name: nuclear factor, interleukin 3, regulated
Synonyms: E4BP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18030
HGNC: HGNC:7787
Homologene: 3928
Fbxl2
Name: F-box and leucine-rich repeat protein 2
Synonyms: 2810423A21Rik, Fbl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72179
Homologene: 135814
Has1
Name: hyaluronan synthase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15116
VEGA: 17
HGNC: HGNC:4818
Homologene: 1165
Krt17
Name: keratin 17
Synonyms: K17, Krt1-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16667
HGNC: HGNC:6427
Homologene: 363
Vmn1r215
Name: vomeronasal 1 receptor 215
Synonyms: V1ri2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171253
Homologene: 110880
Mfsd10
Name: major facilitator superfamily domain containing 10
Synonyms: 0610009O03Rik, Tetran
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68294
Homologene: 871
Neil2
Name: nei like 2 (E. coli)
Synonyms: LOC382913, NEH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 382913
VEGA: 14
Homologene: 17032
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, D4Ertd89e, TRIC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52076
Homologene: 10010
5730596B20Rik
Name: RIKEN cDNA 5730596B20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77580
VEGA: 6
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: 1500005N04Rik, Ihpk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76500
Homologene: 56929
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Nelfcd
Name: negative elongation factor complex member C/D, Th1l
Synonyms: 2410003I03Rik, trihydrophobin 1, Th1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57314
Homologene: 9496
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70839
Homologene: 11260
4930567H17Rik
Name: RIKEN cDNA 4930567H17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 619303
Homologene: 134521
Vmn1r224
Name: vomeronasal 1 receptor 224
Synonyms: Gm7673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665525
Homologene: 85978
Nit2
Name: nitrilase family, member 2
Synonyms: 1190017B19Rik, D16Ertd502e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52633
VEGA: 16
Homologene: 6520
Gm26678
Name: predicted gene, 26678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
B430218F22Rik
Name: RIKEN cDNA B430218F22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Igkv9-120
Name: immunoglobulin kappa chain variable 9-120
Synonyms: Gm5571
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434025
Ighv6-3
Name: immunoglobulin heavy variable 6-3
Synonyms: Gm16930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629845
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 57,388,488 bp
  • T to A, chromosome 1 at 58,833,698 bp
  • T to A, chromosome 1 at 85,589,148 bp
  • T to A, chromosome 1 at 87,931,982 bp
  • T to G, chromosome 1 at 173,682,911 bp
  • A to G, chromosome 2 at 20,887,137 bp
  • A to G, chromosome 2 at 30,026,588 bp
  • T to C, chromosome 2 at 52,050,864 bp
  • C to T, chromosome 2 at 70,016,385 bp
  • T to C, chromosome 2 at 131,139,012 bp
  • T to C, chromosome 2 at 148,675,347 bp
  • T to C, chromosome 2 at 174,427,048 bp
  • T to C, chromosome 3 at 54,633,083 bp
  • T to G, chromosome 3 at 59,257,223 bp
  • T to C, chromosome 4 at 53,840,710 bp
  • A to T, chromosome 4 at 62,336,456 bp
  • A to G, chromosome 4 at 84,293,514 bp
  • A to T, chromosome 4 at 108,625,352 bp
  • G to T, chromosome 4 at 118,478,405 bp
  • G to C, chromosome 4 at 143,794,774 bp
  • G to T, chromosome 5 at 34,635,625 bp
  • A to G, chromosome 5 at 41,821,455 bp
  • T to A, chromosome 5 at 101,922,634 bp
  • T to C, chromosome 5 at 134,670,478 bp
  • A to G, chromosome 6 at 37,964,740 bp
  • G to T, chromosome 6 at 52,178,961 bp
  • A to T, chromosome 6 at 68,050,333 bp
  • T to A, chromosome 7 at 28,156,648 bp
  • T to A, chromosome 7 at 105,085,787 bp
  • T to A, chromosome 7 at 112,110,048 bp
  • T to C, chromosome 7 at 123,171,680 bp
  • T to C, chromosome 8 at 3,450,317 bp
  • T to C, chromosome 8 at 13,167,192 bp
  • A to G, chromosome 8 at 22,011,023 bp
  • T to C, chromosome 9 at 55,418,107 bp
  • T to A, chromosome 9 at 73,530,952 bp
  • A to G, chromosome 9 at 80,345,329 bp
  • G to A, chromosome 9 at 108,805,648 bp
  • T to A, chromosome 9 at 113,989,163 bp
  • G to A, chromosome 10 at 43,022,900 bp
  • T to C, chromosome 10 at 115,418,799 bp
  • T to C, chromosome 11 at 100,257,868 bp
  • C to T, chromosome 12 at 13,223,857 bp
  • T to A, chromosome 12 at 53,139,671 bp
  • C to T, chromosome 12 at 55,640,644 bp
  • T to C, chromosome 12 at 114,391,874 bp
  • C to G, chromosome 13 at 14,317,139 bp
  • T to A, chromosome 13 at 23,075,931 bp
  • T to C, chromosome 13 at 52,968,799 bp
  • T to C, chromosome 13 at 67,177,162 bp
  • T to C, chromosome 13 at 99,405,041 bp
  • T to C, chromosome 13 at 118,386,840 bp
  • A to T, chromosome 14 at 55,513,600 bp
  • G to A, chromosome 14 at 56,018,560 bp
  • A to C, chromosome 14 at 63,191,841 bp
  • C to T, chromosome 15 at 83,620,069 bp
  • T to C, chromosome 16 at 57,157,160 bp
  • G to T, chromosome 17 at 17,850,036 bp
  • T to A, chromosome 17 at 20,419,362 bp
  • A to G, chromosome 18 at 37,695,948 bp
  • A to G, chromosome 19 at 4,322,521 bp
  • T to C, chromosome 19 at 23,374,017 bp
  • C to T, chromosome X at 70,394,529 bp
  • A to G, chromosome X at 101,667,525 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4235 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041052-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.