Strain Name:
C57BL/6J-MtgxR4236Btlr/Mmmh
Stock Number:
041053-MU
Citation ID:
RRID:MMRRC_041053-MU
Other Names:
R4236 (G1), C57BL/6J-MtgxR4236Btlr
Major Collection:

Gene Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 21366
Homologene: 2291
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, MyHC-I, Myhc-b, Myhcb, B-MHC, beta-MHC, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Casp8
Name: caspase 8
Synonyms: Mch5, MACH, Caspase-8, FLICE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Dock5
Name: dedicator of cytokinesis 5
Synonyms: rlc, 1110060D06Rik, lr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68813
VEGA: 14
Homologene: 57016
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: A430078G23Rik, D030053O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319493
Homologene: 32254
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71435
Homologene: 10822
Atg14
Name: autophagy related 14
Synonyms: Barkor, D14Ertd114e, D14Ertd436e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100504663
VEGA: 14
Homologene: 45423
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11736
Homologene: 9491
Tfcp2l1
Name: transcription factor CP2-like 1
Synonyms: Crtr-1, D930018N21Rik, Cp2l1, Tcfcp2l1, 4932442M07Rik, LBP-9, 1810030F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 81879
Homologene: 8730
F2rl1
Name: coagulation factor II (thrombin) receptor-like 1
Synonyms: proteinase-activated receptor-2, Gpcr11, Protease-activated receptor-2, PAR-2, Par2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14063
VEGA: 13
HGNC: HGNC:3538
Homologene: 21087
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239250
VEGA: 14
Homologene: 12986
Spc24
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: Spbc24, 2410030K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67629
VEGA: 9
Homologene: 12166
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: A630023E24Rik, 7330410C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 64706
Homologene: 11224
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, Dnahc7a, LOC381341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Klhl23
Name: kelch-like 23
Synonyms: C130068N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 277396
Homologene: 18628
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235048
HGNC: null
Homologene: 138456
Gm8300
Name: predicted gene 8300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 666806
HGNC: null
Homologene: 103865
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268379
Homologene: 27991
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71355
Homologene: 65061
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, alpha myosin, Myhca, alpha cardiac MHC, A830009F23Rik, Myhc-a, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: A930015H12Rik, SPACR, IMP150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, 2010003K16Rik, RASSF4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74030
Homologene: 32430
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Krt71
Name: keratin 71
Synonyms: Cu, Krt2-6g, mK6irs1, Cal4, Ca, mK6irs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56735
Homologene: 88864
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 670940
HGNC: null
Homologene: 115466
Tulp2
Name: tubby-like protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56734
Homologene: 2492
Olfr53
Name: olfactory receptor 53
Synonyms: MOR253-5, IE12, GA_x6K02T2PBJ9-42798103-42799038
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258962
HGNC: null
Homologene: 133678
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Gal3st2c
Name: galactose-3-O-sulfotransferase 2C
Synonyms: Gm6086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 619597
Homologene: 41471
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243274
Homologene: 71684
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 636697
HGNC: null
Homologene: 41799
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Tas2r140
Name: taste receptor, type 2, member 140
Synonyms: mTRB3, Tas2r40, T2R40, mt2r64, TRB5, Tas2r13, TRB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387616
Homologene: 87013
Dtx3
Name: deltex 3, E3 ubiquitin ligase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 80904
Homologene: 12754
Olfr23
Name: olfactory receptor 23
Synonyms: GA_x6K02T2P1NL-4097159-4098136, MOR135-27, MTPCR50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18321
HGNC: null
Homologene: 115483
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: Ihpk2, 1500005N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76500
Homologene: 56929
Skint11
Name: selection and upkeep of intraepithelial T cells 11
Synonyms: A630098G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230623
HGNC: null
Homologene: 136292
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244853
VEGA: 9
Homologene: 83471
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 2900079B22Rik, 4921504D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70839
Homologene: 11260
4930567H17Rik
Name: RIKEN cDNA 4930567H17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 619303
HGNC: null
Homologene: 134521
Olfr849
Name: olfactory receptor 849
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258520
HGNC: null
Homologene: 74179
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: 2010003I05Rik, Lsm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76522
Homologene: 9419
Ajuba
Name: ajuba LIM protein
Synonyms: Jub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16475
VEGA: 14
Homologene: 7789
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: PC-TsF, Ela1, 1810062B19Rik, Ela-1, 1810009A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
Gm26678
Name: predicted gene, 26678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
B430218F22Rik
Name: RIKEN cDNA B430218F22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 53,447,365 bp
  • T to C, chromosome 1 at 58,844,770 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • T to C, chromosome 1 at 94,008,741 bp
  • G to A, chromosome 1 at 118,662,065 bp
  • A to G, chromosome 2 at 20,887,137 bp
  • T to C, chromosome 2 at 69,824,172 bp
  • C to T, chromosome 2 at 91,167,028 bp
  • A to T, chromosome 2 at 118,709,566 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • T to C, chromosome 3 at 54,633,083 bp
  • T to G, chromosome 3 at 59,257,223 bp
  • G to T, chromosome 3 at 145,524,282 bp
  • C to A, chromosome 4 at 114,244,659 bp
  • G to A, chromosome 5 at 57,719,289 bp
  • A to G, chromosome 5 at 128,432,325 bp
  • T to C, chromosome 6 at 91,741,276 bp
  • A to T, chromosome 6 at 133,054,952 bp
  • A to G, chromosome 7 at 5,544,804 bp
  • A to G, chromosome 7 at 45,521,874 bp
  • A to T, chromosome 7 at 85,563,863 bp
  • A to G, chromosome 7 at 114,521,688 bp
  • T to C, chromosome 7 at 140,652,740 bp
  • T to C, chromosome 8 at 3,450,317 bp
  • C to A, chromosome 8 at 27,393,993 bp
  • T to A, chromosome 9 at 19,441,590 bp
  • T to C, chromosome 9 at 21,756,202 bp
  • T to A, chromosome 9 at 22,249,745 bp
  • A to T, chromosome 9 at 48,398,837 bp
  • A to G, chromosome 9 at 80,345,329 bp
  • G to A, chromosome 9 at 108,805,648 bp
  • A to G, chromosome 10 at 127,193,189 bp
  • A to T, chromosome 11 at 9,256,205 bp
  • G to A, chromosome 11 at 69,396,221 bp
  • G to A, chromosome 11 at 72,714,484 bp
  • A to G, chromosome 11 at 73,940,356 bp
  • T to A, chromosome 12 at 53,139,671 bp
  • A to T, chromosome 12 at 87,517,165 bp
  • A to G, chromosome 13 at 95,513,288 bp
  • T to C, chromosome 13 at 118,386,840 bp
  • T to C, chromosome 14 at 47,551,345 bp
  • T to C, chromosome 14 at 54,569,526 bp
  • T to G, chromosome 14 at 54,960,362 bp
  • T to A, chromosome 14 at 54,991,118 bp
  • A to T, chromosome 14 at 67,756,492 bp
  • T to C, chromosome 14 at 110,750,148 bp
  • C to T, chromosome 15 at 83,620,069 bp
  • T to C, chromosome 15 at 100,682,913 bp
  • T to C, chromosome 15 at 101,734,694 bp
  • C to T, chromosome X at 70,394,529 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4236 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041053-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.