Strain Name:
C57BL/6J-MtgxR4242Btlr/Mmmh
Stock Number:
041059-MU
Citation ID:
RRID:MMRRC_041059-MU
Other Names:
R4242 (G1), C57BL/6J-MtgxR4242Btlr
Major Collection:

Strain Information

Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Nnat
Name: neuronatin
Synonyms: Peg5, 5730414I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18111
HGNC: HGNC:7860
Homologene: 36176
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269400
Homologene: 13168
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228829
Homologene: 9507
Csnk1e
Name: casein kinase 1, epsilon
Synonyms: CKI epsilon, tau, KC1epsilon, CKIepsilon, CK1epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27373
Homologene: 121695
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Igll1
Name: immunoglobulin lambda-like polypeptide 1
Synonyms: Igll, Lambda 5, Igl-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16136
Homologene: 131669
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Xpnpep3
Name: X-prolyl aminopeptidase 3, mitochondrial
Synonyms: E430012M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 321003
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Klhl13
Name: kelch-like 13
Synonyms: 1200009K10Rik, Bklhd2, D130072F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 67455
Homologene: 23571
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16561
Homologene: 99835
Lrmda
Name: leucine rich melanocyte differentiation associated
Synonyms: Oca7, 1700112E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76633
Homologene: 49975
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75339
Homologene: 11380
Tle3
Name: transducin-like enhancer of split 3
Synonyms: Grg3b, Grg3a, ESG, 2610103N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21887
Homologene: 21059
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246788
Homologene: 17040
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Or2a25
Name: olfactory receptor family 2 subfamily A member 25
Synonyms: GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258990
Homologene: 17457
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242721
Homologene: 17567
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl, thrombopoietin receptor, TPO-R, CD110, c-mpl-II, c-mpl-I, hlb219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Gm4841
Name: predicted gene 4841
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225594
VEGA: 18
Vmn1r237
Name: vomeronasal 1 receptor 237
Synonyms: V1rf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171234
Homologene: 64475
Zfp69
Name: zinc finger protein 69
Synonyms: KRAB2, Zfp63, LOC381549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381549
Homologene: 45693
Faim2
Name: Fas apoptotic inhibitory molecule 2
Synonyms: NMP25, 2900002L20Rik, lifeguard, Lfg, Tmbim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72393
VEGA: 15
Homologene: 8192
Or10a48
Name: olfactory receptor family 10 subfamily A member 48
Synonyms: GA_x6K02T2PBJ9-11156311-11155379, MOR268-1, Olfr514
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258721
HGNC: HGNC:8162
Homologene: 73956
Spanxn4
Name: SPANX family, member N4
Synonyms: 1700047L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73309
VEGA: 12
Mad2l1bp
Name: MAD2L1 binding protein
Synonyms: 0610009D16Rik, CMT2B, CMT2A, 2510031P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66591
VEGA: 17
Homologene: 11990
Taf1
Name: TATA-box binding protein associated factor 1
Synonyms: Ccg1, Ccg-1, Taf2a, B430306D02Rik, KAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 270627
Homologene: 37942
Odaph
Name: odontogenesis associated phosphoprotein
Synonyms: LOC381651, Gm1045
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381651
Homologene: 52269
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 11,156,304 bp
  • G to A, chromosome 1 at 34,006,216 bp
  • A to G, chromosome 2 at 156,307,454 bp
  • T to A, chromosome 2 at 157,560,423 bp
  • T to C, chromosome 2 at 181,349,934 bp
  • T to A, chromosome 4 at 118,456,771 bp
  • G to A, chromosome 4 at 120,934,475 bp
  • G to A, chromosome 4 at 139,966,721 bp
  • A to G, chromosome 4 at 149,270,833 bp
  • A to G, chromosome 5 at 91,994,890 bp
  • C to T, chromosome 5 at 104,961,213 bp
  • A to T, chromosome 6 at 42,911,546 bp
  • A to G, chromosome 7 at 108,825,459 bp
  • A to T, chromosome 9 at 61,407,423 bp
  • C to T, chromosome 10 at 76,608,106 bp
  • T to C, chromosome 11 at 73,277,823 bp
  • T to C, chromosome 12 at 62,688,197 bp
  • C to A, chromosome 14 at 22,027,235 bp
  • T to C, chromosome 14 at 56,674,314 bp
  • T to C, chromosome 14 at 67,828,490 bp
  • A to G, chromosome 15 at 79,424,895 bp
  • T to A, chromosome 15 at 81,427,656 bp
  • C to T, chromosome 15 at 85,818,144 bp
  • T to A, chromosome 15 at 99,500,201 bp
  • C to A, chromosome 16 at 16,863,700 bp
  • C to T, chromosome 17 at 15,770,027 bp
  • A to G, chromosome 17 at 21,314,663 bp
  • C to T, chromosome 17 at 32,143,745 bp
  • T to C, chromosome 17 at 46,152,987 bp
  • A to G, chromosome 17 at 78,756,922 bp
  • A to G, chromosome 18 at 60,270,683 bp
  • G to A, chromosome 19 at 38,162,845 bp
  • T to A, chromosome X at 23,315,175 bp
  • T to C, chromosome X at 101,544,503 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041059-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.