Strain Name:
C57BL/6J-MtgxR4285Btlr/Mmmh
Stock Number:
041080-MU
Citation ID:
RRID:MMRRC_041080-MU
Other Names:
R4285 (G1), C57BL/6J-MtgxR4285Btlr
Major Collection:

Gene Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: 1810043O07Rik, LSD1, Aof2, Kdm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 99982
Homologene: 32240
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68151
Homologene: 11779
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
St6galnac3
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Synonyms: ST6GalNAc III, Siat7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20447
Homologene: 7938
Slc20a2
Name: solute carrier family 20, member 2
Synonyms: MolPit2, PiT-2, Ram-1, Ram1, Pit-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20516
Homologene: 68531
Mxd3
Name: Max dimerization protein 3
Synonyms: 4631412E13Rik, Mad3, bHLHc13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17121
Homologene: 32333
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99470
Homologene: 26431
Memo1
Name: mediator of cell motility 1
Synonyms: D930048L02Rik, 0610016J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76890
VEGA: 17
Homologene: 6272
Hnrnph3
Name: heterogeneous nuclear ribonucleoprotein H3
Synonyms: hnRNP 2H9, Hnrph3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432467
HGNC: HGNC:5043
Homologene: 11012
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242608
Homologene: 17803
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 279499
Homologene: 18630
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9430004C13Rik, 9630046L06Rik, 1110061O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Eya2
Name: EYA transcriptional coactivator and phosphatase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14049
HGNC: HGNC:3520
Homologene: 40711
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 4931438M07Rik, 1700052O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22253
Homologene: 2765
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: 1700016J08Rik, PXR2, TRIP8b, Pex2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58869
Homologene: 9562
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
1700123L14Rik
Name: RIKEN cDNA 1700123L14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78482
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Map2k1
Name: mitogen-activated protein kinase kinase 1
Synonyms: MAP kinase kinase 1, Prkmk1, Mek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26395
HGNC: HGNC:6840
Homologene: 2063
Olfr586
Name: olfactory receptor 586
Synonyms: GA_x6K02T2PBJ9-5836380-5835439, MOR8-2, MOR8-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259115
Homologene: 131143
Vat1l
Name: vesicle amine transport protein 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270097
Homologene: 10855
Coq6
Name: coenzyme Q6 monooxygenase
Synonyms: 5930427M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217707
Homologene: 6039
Samm50
Name: SAMM50 sorting and assembly machinery component
Synonyms: 1110030L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68653
VEGA: 15
Homologene: 41034
Rassf2
Name: Ras association (RalGDS/AF-6) domain family member 2
Synonyms: 3830431H01Rik, 9030412M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215653
HGNC: HGNC:9883
Homologene: 22840
Il1rn
Name: interleukin 1 receptor antagonist
Synonyms: IL-1ra, F630041P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16181
HGNC: HGNC:6000
Homologene: 11163
Olfr164
Name: olfactory receptor 164
Synonyms: GA_x54KRFPKG5P-15738260-15737319, MOR279-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258443
HGNC: HGNC:8269
Homologene: 51725
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73422
Homologene: 18421
Slc25a51
Name: solute carrier family 25, member 51
Synonyms: D130005A03Rik, 9130208E07Rik, Mcart1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230125
Homologene: 88487
Cfap73
Name: cilia and flagella associated protein 73
Synonyms: Gm5988, Ccdc42b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 546886
Homologene: 53205
Gm5430
Name: predicted gene 5430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 432543
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 153,234,552 bp
  • T to C, chromosome 2 at 24,349,545 bp
  • G to A, chromosome 2 at 132,005,394 bp
  • T to A, chromosome 2 at 165,724,780 bp
  • A to G, chromosome 3 at 33,007,187 bp
  • A to G, chromosome 3 at 38,889,171 bp
  • T to G, chromosome 3 at 80,707,662 bp
  • C to A, chromosome 3 at 104,015,868 bp
  • G to A, chromosome 3 at 116,752,178 bp
  • T to C, chromosome 3 at 141,714,674 bp
  • A to C, chromosome 3 at 153,206,723 bp
  • A to T, chromosome 3 at 159,934,266 bp
  • A to G, chromosome 4 at 3,905,654 bp
  • C to T, chromosome 4 at 45,399,768 bp
  • C to A, chromosome 4 at 108,021,696 bp
  • T to C, chromosome 4 at 136,582,036 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • G to A, chromosome 5 at 106,635,118 bp
  • T to C, chromosome 5 at 120,632,589 bp
  • T to C, chromosome 6 at 96,165,752 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • T to C, chromosome 7 at 80,368,619 bp
  • G to T, chromosome 7 at 103,122,660 bp
  • G to A, chromosome 8 at 22,561,349 bp
  • C to T, chromosome 8 at 36,574,128 bp
  • G to A, chromosome 8 at 105,382,949 bp
  • A to G, chromosome 8 at 114,205,783 bp
  • C to A, chromosome 9 at 64,212,643 bp
  • A to T, chromosome 10 at 63,016,468 bp
  • C to T, chromosome 12 at 84,370,404 bp
  • T to A, chromosome 12 at 85,094,924 bp
  • A to G, chromosome 13 at 55,329,354 bp
  • GGACGA to GGA, chromosome 14 at 55,499,476 bp
  • T to C, chromosome 15 at 84,197,012 bp
  • A to C, chromosome 16 at 19,285,964 bp
  • A to G, chromosome 16 at 96,709,109 bp
  • A to G, chromosome 17 at 18,135,768 bp
  • A to G, chromosome 17 at 25,322,257 bp
  • T to C, chromosome 17 at 74,255,298 bp
  • G to A, chromosome 18 at 74,714,849 bp
  • T to A, chromosome 19 at 9,016,839 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4285 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041080-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.