Strain Name:
C57BL/6J-MtgxR4291Btlr/Mmmh
Stock Number:
041081-MU
Citation ID:
RRID:MMRRC_041081-MU
Other Names:
R4291 (G1), C57BL/6J-MtgxR4291Btlr
Major Collection:

Gene Information

Gsn
Name: gelsolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Lmf1
Name: lipase maturation factor 1
Synonyms: 2400010G15Rik, Tmem112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76483
Homologene: 23384
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72508
Homologene: 81703
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Mapkapk3
Name: mitogen-activated protein kinase-activated protein kinase 3
Synonyms: MK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102626
HGNC: HGNC:6888
Homologene: 55836
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268936
Homologene: 16092
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Arid1b
Name: AT rich interactive domain 1B (SWI-like)
Synonyms: B230217J03Rik, 9330189K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 239985
Homologene: 32344
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, 1200016O07Rik, sGC-alpha1, Gucy1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Nucb1
Name: nucleobindin 1
Synonyms: MTEST82, B230337F23Rik, Calnuc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18220
HGNC: HGNC:8043
Homologene: 4507
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Dact2
Name: dishevelled-binding antagonist of beta-catenin 2
Synonyms: dapper2, 2900084M21Rik, Frd2, Dpr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240025
VEGA: 17
Homologene: 18237
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: Cox-2, cyclooxygenase 2, Pghs2, COX2, prostaglandin G/H synthase, PHS-2, cyclooxygenase-2, PGHS-2, Tis10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Iqcb1
Name: IQ calmodulin-binding motif containing 1
Synonyms: 6820449I09Rik, NPHP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320299
Homologene: 8766
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229474
Homologene: 18920
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: 1810045E08Rik, MCCalpha, MCCA, 2310058B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194388
Homologene: 35360
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: D7Ertd565e, Nalp9a, Nalp-theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233001
Homologene: 116072
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: LOC330998, B230218L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330998
Homologene: 19814
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Octn3, Slc22a9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56517
Homologene: 137336
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, MHC2A, Myhs-f1, Myhs-f, Myhsf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77827
Homologene: 15880
Mkrn2
Name: makorin, ring finger protein, 2
Synonyms: 2610002L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67027
HGNC: HGNC:7113
Homologene: 8392
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229211
Homologene: 8539
Atf6b
Name: activating transcription factor 6 beta
Synonyms: Creb-rp, ATF6beta, Crebl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 84544
Homologene: 68489
Olfr310
Name: olfactory receptor 310
Synonyms: GA_x6K02T2NHDJ-9838699-9839697, MOR227-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258222
Homologene: 128066
Catip
Name: ciliogenesis associated TTC17 interacting protein
Synonyms: LOC241112, Gm216
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241112
Cckar
Name: cholecystokinin A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12425
HGNC: HGNC:1570
Homologene: 37337
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Gm20547
Name: predicted gene 20547
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219140
Homologene: 19482
Olfr1396
Name: olfactory receptor 1396
Synonyms: GA_x6K02T2QP88-6321048-6321995, MOR276-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258334
Homologene: 28537
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627576
Homologene: 115024
Ctnna2
Name: catenin (cadherin associated protein), alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72344
Homologene: 11828
Zfp488
Name: zinc finger protein 488
Synonyms: LOC382867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 382867
Homologene: 17688
Angel1
Name: angel homolog 1
Synonyms: 1110030H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68737
Homologene: 32251
Amz2
Name: archaelysin family metallopeptidase 2
Synonyms: ESTM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100503496
AK157302
Name: cDNA sequence AK157302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432732
Olfr1120
Name: olfactory receptor 1120
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259031
Homologene: 72054
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433864
Homologene: 39776
Vmn1r238
Name: vomeronasal 1 receptor, 238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100312476
Homologene: 128342
Wfdc1
Name: WAP four-disulfide core domain 1
Synonyms: 2310058A03Rik, ps20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67866
Homologene: 10920
Gm6124
Name: predicted gene 6124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620018
Homologene: 45597
Fam240b
Name: family with sequence similarity 240 member B
Synonyms: 1190003K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68880
Hnrnpa1l2-ps2
Name: heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2
Synonyms: Gm5803
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545091
Homologene: 134075
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,362,668 bp
  • G to A, chromosome 1 at 150,100,251 bp
  • G to T, chromosome 1 at 172,092,397 bp
  • G to A, chromosome 2 at 35,290,420 bp
  • G to A, chromosome 2 at 87,358,075 bp
  • A to G, chromosome 3 at 35,990,068 bp
  • T to C, chromosome 3 at 36,066,188 bp
  • A to T, chromosome 3 at 82,094,759 bp
  • C to A, chromosome 3 at 84,444,826 bp
  • A to G, chromosome 3 at 87,971,934 bp
  • T to A, chromosome 3 at 129,270,317 bp
  • A to G, chromosome 4 at 116,995,692 bp
  • C to A, chromosome 4 at 148,055,492 bp
  • G to A, chromosome 5 at 29,446,372 bp
  • A to G, chromosome 5 at 53,706,497 bp
  • G to A, chromosome 5 at 73,411,932 bp
  • C to T, chromosome 6 at 48,415,665 bp
  • T to A, chromosome 6 at 76,882,745 bp
  • T to C, chromosome 6 at 83,373,199 bp
  • A to G, chromosome 6 at 115,617,434 bp
  • A to T, chromosome 6 at 125,642,322 bp
  • A to G, chromosome 7 at 26,562,590 bp
  • A to T, chromosome 7 at 39,222,771 bp
  • T to A, chromosome 7 at 45,495,280 bp
  • A to T, chromosome 7 at 86,269,760 bp
  • C to A, chromosome 8 at 119,679,455 bp
  • T to A, chromosome 9 at 89,729,764 bp
  • T to C, chromosome 9 at 107,258,932 bp
  • C to A, chromosome 10 at 53,547,572 bp
  • A to G, chromosome 10 at 81,179,580 bp
  • T to A, chromosome 11 at 49,113,427 bp
  • T to C, chromosome 11 at 53,969,503 bp
  • T to C, chromosome 11 at 67,181,159 bp
  • A to T, chromosome 11 at 86,519,876 bp
  • T to C, chromosome 11 at 109,434,055 bp
  • G to A, chromosome 11 at 118,263,647 bp
  • A to G, chromosome 12 at 86,720,283 bp
  • T to A, chromosome 13 at 21,495,545 bp
  • A to T, chromosome 13 at 64,481,813 bp
  • C to A, chromosome 14 at 33,970,894 bp
  • T to A, chromosome 14 at 60,709,555 bp
  • C to A, chromosome 15 at 22,714,551 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • T to C, chromosome 16 at 36,849,673 bp
  • T to A, chromosome 16 at 46,071,749 bp
  • C to T, chromosome 16 at 96,178,774 bp
  • C to A, chromosome 17 at 5,040,663 bp
  • G to T, chromosome 17 at 12,255,260 bp
  • C to T, chromosome 17 at 14,196,571 bp
  • A to T, chromosome 17 at 19,612,041 bp
  • T to C, chromosome 17 at 25,654,481 bp
  • G to A, chromosome 17 at 28,823,975 bp
  • T to C, chromosome 17 at 30,748,559 bp
  • T to A, chromosome 17 at 34,652,674 bp
  • T to G, chromosome 17 at 34,861,138 bp
  • T to C, chromosome 17 at 74,856,479 bp
  • G to A, chromosome 18 at 3,123,214 bp
  • A to C, chromosome 18 at 37,265,417 bp
  • C to T, chromosome 19 at 27,800,232 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4291 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041081-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.