Strain Name:
C57BL/6J-MtgxR4323Btlr/Mmmh
Stock Number:
041094-MU
Citation ID:
RRID:MMRRC_041094-MU
Other Names:
R4323 (G1), C57BL/6J-MtgxR4323Btlr
Major Collection:

Gene Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: BCC2, Gsfbcc2, wh, bHLHe32, mi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Jam2
Name: junction adhesion molecule 2
Synonyms: 2410030G21Rik, Jcam2, 2410167M24Rik, JAM-2, VE-JAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67374
Homologene: 10929
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244672
Homologene: 12366
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Hspy, Flt-2, Eask, Fr1, FGFR-I, Fgfr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L, Ese1, Sh3p17, EHSH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Pdss1
Name: prenyl (solanesyl) diphosphate synthase, subunit 1
Synonyms: mSPS1, 2700031G06Rik, Tprt, 2610203G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56075
Homologene: 5353
Clasp2
Name: CLIP associating protein 2
Synonyms: CLASP2alpha, 1500004F14Rik, CLASP2, 8030404L10Rik, CLASP2gamma, CLASP2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76499
VEGA: 9
Homologene: 24944
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74355
Homologene: 23665
Fbxo38
Name: F-box protein 38
Synonyms: 6030410I24Rik, SP329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 107035
VEGA: 18
Homologene: 34526
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212153
Homologene: 19484
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 9130215G10Rik, 5730455C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66660
VEGA: 9
Homologene: 11696
Esr1
Name: estrogen receptor 1 (alpha)
Synonyms: Nr3a1, Estra, ERalpha, Estr, ER-alpha, ERa, ER[a], ESR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13982
HGNC: HGNC:3467
Homologene: 47906
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230895
Homologene: 15583
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67263
VEGA: 13
Homologene: 83517
Uty
Name: ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 22290
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 386750
Homologene: 8955
Bpnt1
Name: bisphosphate 3'-nucleotidase 1
Synonyms: BPntase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 23827
HGNC: HGNC:1096
Homologene: 4437
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, X83317, 3000002A17Rik, Sur2, Crsp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Sp8
Name: trans-acting transcription factor 8
Synonyms: D930049B17Rik, mBtd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320145
VEGA: 12
Homologene: 18548
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20679
Homologene: 22631
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, NMF355, Clc1, nmf355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, R74981, beta4GalT-III, 9530061M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 210876
Homologene: 86604
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 1110004O12Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 108857
Homologene: 87006
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 433619
Homologene: 54921
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 435975
Homologene: 104832
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Vmn1r46
Name: vomeronasal 1 receptor 46
Synonyms: V1rb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113856
Homologene: 134021
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70950
VEGA: 18
Homologene: 12373
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: FIST3, DYRK6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Parp6
Name: poly (ADP-ribose) polymerase family, member 6
Synonyms: 3110038K10Rik, 2310028P13Rik, 1700119G14Rik, C030013N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67287
VEGA: 9
Homologene: 10627
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
4933430I17Rik
Name: RIKEN cDNA 4933430I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214106
Homologene: 51897
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Fafl2, Dffry
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 107868
Homologene: 68408
Gm15448
Name: predicted gene 15448
Synonyms: ENSMUSG00000074419
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100041146
HGNC: HGNC:6607
Homologene: 134028
Hspa1l
Name: heat shock protein 1-like
Synonyms: 70kDa, Msh5, Hsc70t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15482
HGNC: HGNC:5234
Homologene: 135835
Olfr1392
Name: olfactory receptor 1392
Synonyms: GA_x6K02T2QP88-6141322-6140387, MOR256-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258462
Homologene: 81347
Akr1b3
Name: aldo-keto reductase family 1, member B3 (aldose reductase)
Synonyms: Ahr1, AR, ALR2, Aldor1, Ahr-1, Aldr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Sept1
Name: septin 1
Synonyms: PNUTL3, Diff6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Cry2
Name: cryptochrome 2 (photolyase-like)
Synonyms: D130054K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Smyd2
Name: SET and MYND domain containing 2
Synonyms: 1110020E07Rik, KMT3C, Zmynd14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226830
Homologene: 32466
Pate2
Name: prostate and testis expressed 2
Synonyms: mANLP1, LOC330921
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330921
Homologene: 86016
Wdr55
Name: WD repeat domain 55
Synonyms: 2410080P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67936
VEGA: 18
Homologene: 9789
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • G to T, chromosome 1 at 171,275,942 bp
  • G to T, chromosome 1 at 172,119,264 bp
  • A to C, chromosome 1 at 185,356,589 bp
  • G to A, chromosome 1 at 189,896,601 bp
  • T to C, chromosome 2 at 22,912,596 bp
  • T to C, chromosome 2 at 31,994,684 bp
  • T to G, chromosome 2 at 52,264,110 bp
  • T to C, chromosome 2 at 62,503,372 bp
  • T to C, chromosome 2 at 92,413,906 bp
  • C to A, chromosome 2 at 104,446,571 bp
  • A to G, chromosome 3 at 73,050,785 bp
  • G to A, chromosome 3 at 92,824,856 bp
  • A to G, chromosome 4 at 62,547,311 bp
  • T to A, chromosome 4 at 145,152,778 bp
  • T to C, chromosome 6 at 34,310,927 bp
  • T to C, chromosome 6 at 42,313,098 bp
  • T to C, chromosome 6 at 89,976,367 bp
  • A to G, chromosome 6 at 97,991,949 bp
  • A to G, chromosome 7 at 3,822,755 bp
  • A to G, chromosome 7 at 42,926,982 bp
  • A to G, chromosome 7 at 115,580,563 bp
  • G to A, chromosome 7 at 127,217,028 bp
  • A to G, chromosome 8 at 25,573,899 bp
  • T to G, chromosome 9 at 3,430,452 bp
  • A to T, chromosome 9 at 35,670,471 bp
  • G to A, chromosome 9 at 59,630,686 bp
  • T to C, chromosome 9 at 70,580,247 bp
  • T to C, chromosome 9 at 113,889,959 bp
  • G to A, chromosome 10 at 5,001,307 bp
  • T to C, chromosome 10 at 24,870,705 bp
  • G to A, chromosome 11 at 49,293,676 bp
  • T to C, chromosome 11 at 87,796,039 bp
  • A to G, chromosome 12 at 118,848,436 bp
  • G to A, chromosome 13 at 107,889,403 bp
  • A to G, chromosome 16 at 43,947,509 bp
  • T to C, chromosome 16 at 84,822,856 bp
  • G to A, chromosome 16 at 91,818,552 bp
  • A to T, chromosome 17 at 22,573,178 bp
  • T to A, chromosome 17 at 34,977,856 bp
  • A to G, chromosome 17 at 71,428,275 bp
  • T to A, chromosome 18 at 22,033,543 bp
  • C to T, chromosome 18 at 36,578,633 bp
  • A to G, chromosome 18 at 36,763,100 bp
  • T to A, chromosome 18 at 62,515,161 bp
  • T to C, chromosome Y at 1,245,538 bp
  • T to A, chromosome Y at 1,434,407 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4323 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041094-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.