Strain Name:
C57BL/6J-MtgxR4348Btlr/Mmmh
Stock Number:
041103-MU
Citation ID:
RRID:MMRRC_041103-MU
Other Names:
R4348 (G1), C57BL/6J-MtgxR4348Btlr
Major Collection:

Gene Information

Smco3
Name: single-pass membrane protein with coiled-coil domains 3
Synonyms: C030030A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 654818
VEGA: 6
Homologene: 79087
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: OTTMUSG00000012483, C030040A15Rik, 9430004D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 109241
VEGA: 2
Homologene: 81861
Ptch1
Name: patched 1
Synonyms: Patched 1, wig, Ptc1, Ptc, A230106A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19206
VEGA: 13
HGNC: HGNC:9585
Homologene: 223
Ebf2
Name: early B cell factor 2
Synonyms: O/E-3, D14Ggc1e, Mmot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13592
VEGA: 14
Homologene: 56471
Prdm16
Name: PR domain containing 16
Synonyms: csp1, Mel1, 5730557K01Rik, line 27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 70673
VEGA: 4
Homologene: 11139
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13800
VEGA: 1
Homologene: 134005
Rnf38
Name: ring finger protein 38
Synonyms: Oip1, 1700065B19Rik, 2610202O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73469
VEGA: 4
Homologene: 32550
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22390
VEGA: 7
Homologene: 31152
Fam160a2
Name: family with sequence similarity 160, member A2
Synonyms: 4632419K20Rik, 6530415H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74349
VEGA: 7
Homologene: 75329
Inava
Name: innate immunity activator
Synonyms: 5730559C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67313
VEGA: 1
Homologene: 10103
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Evi1, MDS1-EVI1, Jbo, Prdm3, D630039M04Rik, Evi-1, Mds1, ZNFPR1B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14013
VEGA: 3
HGNC: HGNC:3498
Homologene: 21086
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219228
VEGA: 14
Homologene: 8700
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
VEGA: 2
Homologene: 130650
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: Ptpri, PTPL1, PTP-BL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19249
VEGA: 5
HGNC: HGNC:9646
Homologene: 7909
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, DLP12, Dnahc12, 4921531P07Rik, LOC380889, HL-19, DHC3, HL19, Dnahc7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110083
VEGA: 14
HGNC: HGNC:2943
Homologene: 56821
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 246707
VEGA: 17
Homologene: 36483
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: CNG6, Cngbeta2, CCNC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 30952
VEGA: 4
HGNC: HGNC:2153
Homologene: 40908
Gm1966
Name: predicted gene 1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434223
Homologene: 32708
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Cntnap4
Name: contactin associated protein-like 4
Synonyms: E130114F09Rik, Caspr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 170571
VEGA: 8
Homologene: 24912
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: C330021H03Rik, Gm10331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100045792
Homologene: 46005
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232400
VEGA: 6
Homologene: 45969
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381260
VEGA: 1
Homologene: 124277
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: METH-1, METH1, ADAMTS-1, ADAM-TS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11504
VEGA: 16
HGNC: HGNC:217
Homologene: 21381
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 30956
VEGA: 6
Homologene: 4212
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
Synonyms: Fam59b, Gareml, LOC242915
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242915
VEGA: 5
Homologene: 19063
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224916
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16897
VEGA: 11
HGNC: HGNC:6628
Homologene: 31220
Rnf31
Name: ring finger protein 31
Synonyms: Paul, HOIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268749
VEGA: 14
Homologene: 33228
Prb1
Name: proline-rich protein BstNI subfamily 1
Synonyms: proline-rich proteoglycan 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381833
VEGA: 6
HGNC: HGNC:9338
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71007
VEGA: 7
Homologene: 18998
Ssx2ip
Name: synovial sarcoma, X 2 interacting protein
Synonyms: Adip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99167
VEGA: 3
Homologene: 8522
Kcns3
Name: potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Synonyms: D12Ertd137e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238076
VEGA: 12
HGNC: HGNC:6302
Homologene: 20518
Gpatch11
Name: G patch domain containing 11
Synonyms: 2310002B06Rik, Ccdc75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 53951
VEGA: 17
Homologene: 44687
Gm12743
Name: predicted gene 12743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Gfy
Name: golgi-associated olfactory signaling regulator
Synonyms: Goofy, Gm581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100039953
VEGA: 7
Homologene: 85248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 59,558,165 bp
  • C to T, chromosome 1 at 136,226,208 bp
  • A to T, chromosome 1 at 181,922,420 bp
  • T to A, chromosome 2 at 49,256,327 bp
  • A to G, chromosome 2 at 76,764,765 bp
  • C to A, chromosome 3 at 29,966,738 bp
  • T to C, chromosome 3 at 146,432,490 bp
  • G to A, chromosome 4 at 19,396,688 bp
  • A to T, chromosome 4 at 44,149,100 bp
  • C to T, chromosome 4 at 108,593,452 bp
  • A to G, chromosome 4 at 154,476,667 bp
  • G to A, chromosome 5 at 30,105,368 bp
  • T to A, chromosome 5 at 103,569,726 bp
  • A to G, chromosome 6 at 23,113,739 bp
  • C to T, chromosome 6 at 128,580,386 bp
  • T to G, chromosome 6 at 132,313,661 bp
  • T to A, chromosome 6 at 136,831,694 bp
  • T to C, chromosome 7 at 45,177,616 bp
  • A to G, chromosome 7 at 105,385,349 bp
  • T to A, chromosome 7 at 106,600,542 bp
  • A to G, chromosome 7 at 110,130,958 bp
  • ACCTAGGAGGTCCT to ACCT, chromosome 7 at 134,348,953 bp
  • T to A, chromosome 8 at 112,753,922 bp
  • G to A, chromosome 9 at 45,919,348 bp
  • A to G, chromosome 10 at 18,136,988 bp
  • C to T, chromosome 11 at 60,709,568 bp
  • T to C, chromosome 12 at 11,091,381 bp
  • A to G, chromosome 13 at 58,878,259 bp
  • C to T, chromosome 13 at 63,534,329 bp
  • T to A, chromosome 14 at 26,814,541 bp
  • AAC to A, chromosome 14 at 55,601,098 bp
  • T to C, chromosome 14 at 67,239,422 bp
  • T to C, chromosome 14 at 84,447,620 bp
  • A to T, chromosome 15 at 98,604,160 bp
  • A to G, chromosome 15 at 103,486,819 bp
  • T to A, chromosome 16 at 85,802,346 bp
  • A to T, chromosome 17 at 57,522,466 bp
  • T to C, chromosome 17 at 71,280,731 bp
  • T to C, chromosome 17 at 78,841,017 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4348 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041103-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.