Strain Name:
C57BL/6J-MtgxR4348Btlr/Mmmh
Stock Number:
041103-MU
Citation ID:
RRID:MMRRC_041103-MU
Other Names:
R4348 (G1), C57BL/6J-MtgxR4348Btlr
Major Collection:

Strain Information

Smco3
Name: single-pass membrane protein with coiled-coil domains 3
Synonyms: C030030A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 654818
Homologene: 79087
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: C030027L06Rik, trkB, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109241
Homologene: 81861
Ptch1
Name: patched 1
Synonyms: wig, Ptc, Ptc1, Patched 1, A230106A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Ebf2
Name: early B cell factor 2
Synonyms: Mmot1, O/E-3, D14Ggc1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13592
Homologene: 56471
Prdm16
Name: PR domain containing 16
Synonyms: line 27, 5730557K01Rik, Mel1, csp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70673
Homologene: 11139
Enah
Name: ENAH actin regulator
Synonyms: Ndpp1, Mena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13800
Homologene: 134005
Rnf38
Name: ring finger protein 38
Synonyms: 1700065B19Rik, Oip1, 2610202O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73469
Homologene: 32550
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22390
Homologene: 31152
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: Fam160a2, 4632419K20Rik, 6530415H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74349
Homologene: 75329
Inava
Name: innate immunity activator
Synonyms: 5730559C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67313
Homologene: 10103
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: MDS1-EVI1, ZNFPR1B1, Prdm3, D630039M04Rik, Mds1, Evi1, Jbo, Evi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Ttn
Name: titin
Synonyms: D330041I19Rik, 2310057K23Rik, connectin, shru, 1100001C23Rik, L56, mdm, D830007G01Rik, 2310074I15Rik, 2310036G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: Ptpri, PTPL1, PTP-BL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc7l, LOC380889, DHC3, DLP12, HL-19, Hdhc3, Dnahc12, 4921531P07Rik, HL19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: FOAP-10, basilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: CNG6, Cngbeta2, CCNC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: BC048546, Ovos2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232400
Homologene: 45969
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: ADAMTS-1, ADAM-TS1, METH-1, METH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30956
Homologene: 4212
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
Synonyms: Fam59b, LOC242915, Gareml
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242915
Homologene: 19063
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224916
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Rnf31
Name: ring finger protein 31
Synonyms: Paul, HOIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268749
Homologene: 33228
Prb1a
Name: proline-rich protein BstNI subfamily 1A
Synonyms: proline-rich proteoglycan 2, Prb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381833
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: Fats, 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71007
Homologene: 18998
Ssx2ip
Name: SSX family member 2 interacting protein
Synonyms: Adip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99167
Homologene: 8522
Kcns3
Name: potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Synonyms: D12Ertd137e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238076
VEGA: 12
HGNC: HGNC:6302
Homologene: 20518
Gpatch11
Name: G patch domain containing 11
Synonyms: Ccdc75, 2310002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 53951
VEGA: 17
Homologene: 44687
Gm12743
Name: predicted gene 12743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 115489936
Gfy
Name: golgi-associated olfactory signaling regulator
Synonyms: Goofy, Gm581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039953
Homologene: 85248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 59,558,165 bp
  • C to T, chromosome 1 at 136,226,208 bp
  • A to T, chromosome 1 at 181,922,420 bp
  • T to A, chromosome 2 at 49,256,327 bp
  • A to G, chromosome 2 at 76,764,765 bp
  • C to A, chromosome 3 at 29,966,738 bp
  • T to C, chromosome 3 at 146,432,490 bp
  • G to A, chromosome 4 at 19,396,688 bp
  • A to T, chromosome 4 at 44,149,100 bp
  • C to T, chromosome 4 at 108,593,452 bp
  • A to G, chromosome 4 at 154,476,667 bp
  • G to A, chromosome 5 at 30,105,368 bp
  • T to A, chromosome 5 at 103,569,726 bp
  • A to G, chromosome 6 at 23,113,739 bp
  • C to T, chromosome 6 at 128,580,386 bp
  • T to G, chromosome 6 at 132,313,661 bp
  • T to A, chromosome 6 at 136,831,694 bp
  • T to C, chromosome 7 at 45,177,616 bp
  • A to G, chromosome 7 at 105,385,349 bp
  • T to A, chromosome 7 at 106,600,542 bp
  • A to G, chromosome 7 at 110,130,958 bp
  • ACCTAGGAGGTCCT to ACCT, chromosome 7 at 134,348,953 bp
  • T to A, chromosome 8 at 112,753,922 bp
  • G to A, chromosome 9 at 45,919,348 bp
  • A to G, chromosome 10 at 18,136,988 bp
  • C to T, chromosome 11 at 60,709,568 bp
  • T to C, chromosome 12 at 11,091,381 bp
  • A to G, chromosome 13 at 58,878,259 bp
  • C to T, chromosome 13 at 63,534,329 bp
  • T to A, chromosome 14 at 26,814,541 bp
  • AAC to A, chromosome 14 at 55,601,098 bp
  • T to C, chromosome 14 at 67,239,422 bp
  • T to C, chromosome 14 at 84,447,620 bp
  • A to T, chromosome 15 at 98,604,160 bp
  • A to G, chromosome 15 at 103,486,819 bp
  • T to A, chromosome 16 at 85,802,346 bp
  • A to T, chromosome 17 at 57,522,466 bp
  • T to C, chromosome 17 at 71,280,731 bp
  • T to C, chromosome 17 at 78,841,017 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4348 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041103-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.