Strain Name:
C57BL/6J-MtgxR4365Btlr/Mmmh
Stock Number:
041113-MU
Citation ID:
RRID:MMRRC_041113-MU
Other Names:
R4365 (G1), C57BL/6J-MtgxR4365Btlr
Major Collection:

Gene Information

Btrc
Name: beta-transducin repeat containing protein
Synonyms: SCF b-TRCP, beta-TrCP, Fbw1a, Beta-Trcp1, Slimb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12234
VEGA: 19
HGNC: HGNC:1144
Homologene: 39330
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: p38 MAP kinase alpha, p38, p38 MAP Kinase, p38-alpha, p38a, p38 alpha, Crk1, CSBP2, Mxi2, p38 MAPK, p38MAPK, p38alpha, Csbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2610301K12Rik, 2810431I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72477
Homologene: 69513
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, A430032G04Rik, A430040A19Rik, D630005A10Rik, Bruce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, 6330500D04Rik, Fam65b, E430013J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193385
Homologene: 9284
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, KAT13C, bHLHe75, D1Ertd433e, TIF2/GRIP-1, TIF2, glucocorticoid receptor-interacting protein 1, TIF-2, Grip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Optn
Name: optineurin
Synonyms: 4930441O07Rik, TFIIIA-INTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71648
Homologene: 11085
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, MLSN2, 6330504P12Rik, LTRPC3, melastatin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Ephx4
Name: epoxide hydrolase 4
Synonyms: Abhd7, LOC384214
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384214
Homologene: 62402
C4b
Name: complement component 4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: Nt5c2l1, 6030401B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319638
Homologene: 16281
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239081
Homologene: 77905
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Lrit2
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
Synonyms: Lrrc22, A930010E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239038
VEGA: 14
Homologene: 18292
Olfr805
Name: olfactory receptor 805
Synonyms: MOR110-4, GA_x6K02T2PULF-11402237-11401278
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258548
Olfr491
Name: olfactory receptor 491
Synonyms: MOR204-11, GA_x6K02T2PBJ9-10646917-10647849
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258731
Homologene: 128150
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Ncan
Name: neurocan
Synonyms: Cspg3, Cspg3-rs, Tgfbit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Ube4a
Name: ubiquitination factor E4A
Synonyms: 9930123J21Rik, UFD2b, 4732444G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98733
Hspa4l
Name: heat shock protein 4 like
Synonyms: 94kDa, Osp94, APG-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18415
Homologene: 22610
St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms: PST-1, PST, ST8SiaIV, Siat8d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20452
Homologene: 4147
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: 1110013O17Rik, EMILIN-T, Emilin5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 280635
Homologene: 18817
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101100
Homologene: 134361
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56709
Homologene: 9749
C230029F24Rik
Name: RIKEN cDNA C230029F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 442837
Rnf150
Name: ring finger protein 150
Synonyms: A630007N06Rik, C030044C12Rik, Greul5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330812
Homologene: 33783
Cacna1f
Name: calcium channel, voltage-dependent, alpha 1F subunit
Synonyms: Sfc17, Cav1.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54652
HGNC: HGNC:1393
Homologene: 74542
Ccdc153
Name: coiled-coil domain containing 153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270150
VEGA: 9
Homologene: 26818
Olfr110
Name: olfactory receptor 110
Synonyms: MOR249-2, GA_x6K02T2PSCP-1956307-1957260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258325
Homologene: 73968
S100a9
Name: S100 calcium binding protein A9 (calgranulin B)
Synonyms: 60B8Ag, BEE22, MRP14, L1Ag, p14, Cagb, GAGB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20202
Homologene: 2227
Gm26858
Name: predicted gene, 26858
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,180,547 bp
  • G to T, chromosome 1 at 40,351,791 bp
  • A to G, chromosome 1 at 49,310,917 bp
  • A to C, chromosome 1 at 75,488,049 bp
  • A to T, chromosome 1 at 95,591,792 bp
  • A to G, chromosome 1 at 164,184,950 bp
  • C to A, chromosome 2 at 5,024,077 bp
  • T to A, chromosome 2 at 101,642,943 bp
  • A to G, chromosome 2 at 128,841,324 bp
  • T to C, chromosome 2 at 160,908,486 bp
  • C to A, chromosome 3 at 40,766,809 bp
  • T to C, chromosome 3 at 90,692,774 bp
  • A to G, chromosome 5 at 107,403,813 bp
  • T to C, chromosome 6 at 113,399,008 bp
  • A to T, chromosome 7 at 108,317,106 bp
  • A to G, chromosome 8 at 70,115,211 bp
  • A to G, chromosome 8 at 82,864,115 bp
  • G to A, chromosome 9 at 44,243,592 bp
  • T to C, chromosome 9 at 44,960,081 bp
  • C to A, chromosome 9 at 108,829,847 bp
  • T to A, chromosome 9 at 114,631,881 bp
  • T to C, chromosome 10 at 34,310,381 bp
  • T to C, chromosome 10 at 59,879,766 bp
  • A to G, chromosome 10 at 129,723,412 bp
  • A to T, chromosome 12 at 8,016,083 bp
  • C to T, chromosome 13 at 24,721,711 bp
  • T to A, chromosome 14 at 37,072,119 bp
  • T to A, chromosome 14 at 50,361,469 bp
  • A to G, chromosome 14 at 84,448,286 bp
  • C to T, chromosome 17 at 28,741,746 bp
  • T to C, chromosome 17 at 32,376,961 bp
  • T to A, chromosome 17 at 34,734,743 bp
  • T to C, chromosome 17 at 37,499,379 bp
  • T to C, chromosome 17 at 74,615,375 bp
  • A to G, chromosome 19 at 22,978,330 bp
  • A to T, chromosome 19 at 33,721,708 bp
  • G to A, chromosome 19 at 45,513,480 bp
  • G to T, chromosome X at 7,609,974 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4365 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041113-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.