Strain Name:
C57BL/6J-MtgxR4366Btlr/Mmmh
Stock Number:
041114-MU
Citation ID:
RRID:MMRRC_041114-MU
Other Names:
R4366 (G1), C57BL/6J-MtgxR4366Btlr
Major Collection:

Gene Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 52615
Homologene: 32256
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: OTTMUSG00000012483, C030040A15Rik, 9430004D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 109241
Homologene: 81861
Mcoln3
Name: mucolipin 3
Synonyms: varitint-waddler, TRPML3, 6720490O21Rik, Va
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 171166
Homologene: 10118
App
Name: amyloid beta (A4) precursor protein
Synonyms: Adap, Abeta, appican, betaAPP, E030013M08Rik, Cvap, protease nexin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
2310061I04Rik
Name: RIKEN cDNA 2310061I04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 69662
Homologene: 17027
Csnk1g1
Name: casein kinase 1, gamma 1
Synonyms: 9130020E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214897
HGNC: HGNC:2454
Homologene: 48692
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22222
Homologene: 7582
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70699
Homologene: 45971
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22763
Homologene: 8009
Epc2
Name: enhancer of polycomb homolog 2
Synonyms: D2Ertd694e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227867
Homologene: 32274
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83946
Homologene: 41209
Ddx46
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Synonyms: 8430438J23Rik, 2200005K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 212880
VEGA: 13
Homologene: 5430
Fkbp15
Name: FK506 binding protein 15
Synonyms: C430014M02Rik, FKBP133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 338355
Homologene: 28743
Sf3a3
Name: splicing factor 3a, subunit 3
Synonyms: 4930512K19Rik, 60kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75062
Homologene: 4949
Ipo7
Name: importin 7
Synonyms: RanBP7, Imp7, A330055O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233726
HGNC: HGNC:9852
Homologene: 4659
Ereg
Name: epiregulin
Synonyms: EPR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13874
HGNC: HGNC:3443
Homologene: 1097
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Timp2
Name: tissue inhibitor of metalloproteinase 2
Synonyms: D11Bwg1104e, TIMP-2, Timp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21858
Homologene: 2444
Efnb3
Name: ephrin B3
Synonyms: ELF-3, Elk-L3, Epl8, NLERK-2, EFL-6, LERK-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13643
HGNC: HGNC:3228
Homologene: 1076
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, 1700108N18Rik, 6330500D04Rik, E430013J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 193385
Homologene: 9284
Cldn6
Name: claudin 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54419
HGNC: HGNC:2048
Homologene: 10300
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Elf2
Name: E74-like factor 2
Synonyms: 2610036A20Rik, NERF-2, A230104O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69257
HGNC: HGNC:3317
Homologene: 5006
March7
Name: membrane-associated ring finger (C3HC4) 7
Synonyms: Axot, Gtrgeo17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 57438
Homologene: 10753
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: 9830169D19Rik, Vdu1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170822
Homologene: 8996
Elmsan1
Name: ELM2 and Myb/SANT-like domain containing 1
Synonyms: C130039O16Rik, 9430029N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238317
Homologene: 19330
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224792
VEGA: 17
Homologene: 9065
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, Myospryn, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76469
VEGA: 13
Homologene: 137367
Evc2
Name: EvC ciliary complex subunit 2
Synonyms: Ellis van Creveld syndrome 2, limbin, Lbn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 68525
Homologene: 17117
Olfr800
Name: olfactory receptor 800
Synonyms: MOR114-7, GA_x6K02T2PULF-11338429-11339364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258541
Homologene: 27203
Rhbdl2
Name: rhomboid like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230726
Homologene: 49508
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 117229
Homologene: 75307
Ephx4
Name: epoxide hydrolase 4
Synonyms: LOC384214, Abhd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384214
Homologene: 62402
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, Cav2.2, alpha(1B)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 68802
VEGA: 10
Homologene: 23778
Slc25a29
Name: solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29
Synonyms: mCACL, CACL, C030003J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 214663
Homologene: 5385
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: Opo, ojoplano
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218165
VEGA: 13
Homologene: 125376
Apol7c
Name: apolipoprotein L 7c
Synonyms: 2210421G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 108956
VEGA: 15
Homologene: 40940
Mrgprx1
Name: MAS-related GPR, member X1
Synonyms: Mrgprc11, MrgC11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 404242
Homologene: 86184
Mcam
Name: melanoma cell adhesion molecule
Synonyms: CD146, 1-gicerin, s-gicerin, Muc18, s-endo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 84004
HGNC: HGNC:6934
Homologene: 4742
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98733
Hspa4l
Name: heat shock protein 4 like
Synonyms: 94kDa, APG-1, Osp94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18415
Homologene: 22610
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21897
Homologene: 20694
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, E030045D18Rik, Schnurri-3, 2900056N03Rik, Shn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16656
Homologene: 7803
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 100126226
HGNC: HGNC:6460
Homologene: 68248
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94253
VEGA: 13
Homologene: 9004
Cacna1f
Name: calcium channel, voltage-dependent, alpha 1F subunit
Synonyms: Cav1.4, Sfc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 54652
HGNC: HGNC:1393
Homologene: 74542
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230909
Homologene: 52134
C4a
Name: complement component 4A (Rodgers blood group)
Synonyms: Slp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 625018
Homologene: 36030
Olfr876
Name: olfactory receptor 876
Synonyms: GA_x6K02T2PVTD-31489645-31490577, MOR161-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258883
Homologene: 74154
Spinkl
Name: serine protease inhibitor, Kazal type-like
Synonyms: 9530002K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 77424
VEGA: 18
Homologene: 128818
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Tmem200b
Name: transmembrane protein 200B
Synonyms: EG623230
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 623230
VEGA: 4
Homologene: 79738
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,251,878 bp
  • A to C, chromosome 1 at 75,488,049 bp
  • T to C, chromosome 2 at 24,702,620 bp
  • T to A, chromosome 2 at 49,272,966 bp
  • A to G, chromosome 2 at 49,547,554 bp
  • A to C, chromosome 2 at 60,234,083 bp
  • C to A, chromosome 2 at 120,970,603 bp
  • T to C, chromosome 2 at 140,660,407 bp
  • A to G, chromosome 3 at 19,310,862 bp
  • C to A, chromosome 3 at 40,766,809 bp
  • G to A, chromosome 3 at 51,308,149 bp
  • C to A, chromosome 3 at 146,140,492 bp
  • C to A, chromosome 3 at 152,368,512 bp
  • A to G, chromosome 4 at 62,336,414 bp
  • A to C, chromosome 4 at 120,096,089 bp
  • T to A, chromosome 4 at 123,809,935 bp
  • A to G, chromosome 4 at 124,725,139 bp
  • A to G, chromosome 4 at 131,922,470 bp
  • A to G, chromosome 4 at 148,654,865 bp
  • C to A, chromosome 5 at 37,338,669 bp
  • C to T, chromosome 5 at 64,925,837 bp
  • T to C, chromosome 5 at 91,086,800 bp
  • A to G, chromosome 5 at 107,403,813 bp
  • C to A, chromosome 6 at 35,192,027 bp
  • C to A, chromosome 7 at 48,021,193 bp
  • G to A, chromosome 7 at 109,279,795 bp
  • T to C, chromosome 7 at 110,029,712 bp
  • A to T, chromosome 7 at 110,048,216 bp
  • A to T, chromosome 9 at 37,804,190 bp
  • T to A, chromosome 9 at 44,134,697 bp
  • A to G, chromosome 9 at 66,019,853 bp
  • C to T, chromosome 9 at 82,900,869 bp
  • T to C, chromosome 10 at 63,192,708 bp
  • A to T, chromosome 10 at 129,660,531 bp
  • T to C, chromosome 11 at 69,555,945 bp
  • T to A, chromosome 11 at 80,002,162 bp
  • T to A, chromosome 11 at 118,310,671 bp
  • A to T, chromosome 12 at 8,016,083 bp
  • C to T, chromosome 12 at 84,156,471 bp
  • C to T, chromosome 12 at 108,831,171 bp
  • C to T, chromosome 13 at 14,316,164 bp
  • C to T, chromosome 13 at 24,721,711 bp
  • A to G, chromosome 13 at 40,015,461 bp
  • T to A, chromosome 13 at 55,663,236 bp
  • T to C, chromosome 13 at 93,091,956 bp
  • A to G, chromosome 15 at 12,156,330 bp
  • T to G, chromosome 15 at 77,526,389 bp
  • T to G, chromosome 15 at 101,487,514 bp
  • G to T, chromosome 16 at 85,056,433 bp
  • G to C, chromosome 17 at 23,681,520 bp
  • T to A, chromosome 17 at 34,814,908 bp
  • T to C, chromosome 17 at 35,895,316 bp
  • A to C, chromosome 17 at 43,441,969 bp
  • A to G, chromosome 18 at 37,754,072 bp
  • T to G, chromosome 18 at 44,174,583 bp
  • T to A, chromosome 18 at 49,878,017 bp
  • G to T, chromosome X at 7,609,974 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4366 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041114-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.