Strain Name:
C57BL/6J-MtgxR4368Btlr/Mmmh
Stock Number:
041115-MU
Citation ID:
RRID:MMRRC_041115-MU
Other Names:
R4368 (G1), C57BL/6J-MtgxR4368Btlr
Major Collection:

Gene Information

Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBCn1, NBC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Efr3a
Name: EFR3 homolog A
Synonyms: C920006C10Rik, A130089M23Rik, D030063F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76740
Homologene: 44222
Armc6
Name: armadillo repeat containing 6
Synonyms: 2410153K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76813
Homologene: 14121
Dhx38
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 38
Synonyms: Prp16, 5730550P09Rik, Ddx38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64340
Homologene: 8512
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A630086M08Rik, Rbm16, A930036P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Cep120
Name: centrosomal protein 120
Synonyms: Ccdc100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225523
VEGA: 18
Homologene: 27415
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21341
Homologene: 21163
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: 1810009G08Rik, PNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Cdh19
Name: cadherin 19, type 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227485
HGNC: HGNC:1758
Homologene: 23286
Pdgfa
Name: platelet derived growth factor, alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18590
HGNC: HGNC:8799
Homologene: 32055
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: ATP-dependent metalloprotease FtsH1, Ftsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27377
Homologene: 31996
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74044
Homologene: 37826
Zfp534
Name: zinc finger protein 534
Synonyms: Gm13159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100503584
Homologene: 133076
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Trim45
Name: tripartite motif-containing 45
Synonyms: 4921530N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229644
Homologene: 11865
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: GC-LRR, Nalp14, Nalp-iota, 4921520L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76858
Homologene: 18531
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, beta4GalT-III, 9530061M23Rik, R74981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Hspb7
Name: heat shock protein family, member 7 (cardiovascular)
Synonyms: cvHsp, Hsp25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29818
HGNC: HGNC:5249
Homologene: 8480
Adamts7
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433597
Homologene: 79018
Vmn1r178
Name: vomeronasal 1 receptor 178
Synonyms: V1rd13, LOC232959
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232959
Homologene: 104166
Zscan12
Name: zinc finger and SCAN domain containing 12
Synonyms: Zfp96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22758
Homologene: 86980
Wdr46
Name: WD repeat domain 46
Synonyms: 2310007I04Rik, Bing4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57315
Homologene: 3981
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Olfr267
Name: olfactory receptor 267
Synonyms: MOR262-1, GA_x6K02T2N78B-1272842-1273783
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258922
HGNC: HGNC:8264
Homologene: 17436
Tor1a
Name: torsin family 1, member A (torsin A)
Synonyms: Tor1a, DQ2, Dyt1, torsinA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30931
HGNC: HGNC:3098
Homologene: 37263
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64379
Homologene: 41481
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625131
Homologene: 129606
Phactr2
Name: phosphatase and actin regulator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215789
Homologene: 8816
Mapk13
Name: mitogen-activated protein kinase 13
Synonyms: Serk4, p38 delta MAP kinase, SAPK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26415
HGNC: HGNC:6875
Homologene: 48133
Psph
Name: phosphoserine phosphatase
Synonyms: PSPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100678
HGNC: HGNC:9577
Homologene: 31245
Klhl22
Name: kelch-like 22
Synonyms: Kelchl, 2610318I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224023
Homologene: 23784
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103733
Homologene: 833
Gm16140
Name: predicted gene 16140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 101055656
Ttll8
Name: tubulin tyrosine ligase-like family, member 8
Synonyms: 1700019P01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239591
Homologene: 52766
Jhy
Name: junctional cadherin complex regulator
Synonyms: 4931429I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70989
Homologene: 11726
Zfp263
Name: zinc finger protein 263
Synonyms: mFPM315, NT2, 1200014J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74120
Homologene: 4197
Paqr3
Name: progestin and adipoQ receptor family member III
Synonyms: RKTG, 6330415A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231474
Homologene: 71077
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: SPEER-3, 4933405P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71026
Homologene: 69402
4930449A18Rik
Name: RIKEN cDNA 4930449A18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 110,889,712 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • A to G, chromosome 2 at 23,160,211 bp
  • A to G, chromosome 2 at 30,967,370 bp
  • C to T, chromosome 3 at 36,988,147 bp
  • T to C, chromosome 3 at 59,751,966 bp
  • A to G, chromosome 3 at 59,846,778 bp
  • T to C, chromosome 3 at 100,923,186 bp
  • C to T, chromosome 3 at 100,948,199 bp
  • T to C, chromosome 4 at 58,785,153 bp
  • A to T, chromosome 4 at 141,424,018 bp
  • T to C, chromosome 4 at 147,675,558 bp
  • C to G, chromosome 5 at 13,796,380 bp
  • T to C, chromosome 5 at 97,108,291 bp
  • T to G, chromosome 5 at 129,771,590 bp
  • T to C, chromosome 5 at 138,986,306 bp
  • A to T, chromosome 7 at 23,894,022 bp
  • A to G, chromosome 7 at 44,862,266 bp
  • A to G, chromosome 7 at 107,197,805 bp
  • G to A, chromosome 8 at 70,225,293 bp
  • A to G, chromosome 8 at 92,678,401 bp
  • C to T, chromosome 8 at 109,553,131 bp
  • A to C, chromosome 8 at 119,599,316 bp
  • T to A, chromosome 9 at 40,917,144 bp
  • G to A, chromosome 9 at 90,195,851 bp
  • A to G, chromosome 10 at 13,253,820 bp
  • A to G, chromosome 10 at 130,479,807 bp
  • A to T, chromosome 11 at 19,010,656 bp
  • G to T, chromosome 11 at 101,125,364 bp
  • T to C, chromosome 12 at 17,379,292 bp
  • T to C, chromosome 12 at 98,678,593 bp
  • T to C, chromosome 13 at 21,369,383 bp
  • C to A, chromosome 13 at 73,560,912 bp
  • A to C, chromosome 13 at 81,492,910 bp
  • C to T, chromosome 14 at 14,733,775 bp
  • T to A, chromosome 15 at 65,866,780 bp
  • G to A, chromosome 15 at 88,914,181 bp
  • T to A, chromosome 16 at 3,744,906 bp
  • T to C, chromosome 16 at 17,789,273 bp
  • T to C, chromosome 17 at 3,171,195 bp
  • A to G, chromosome 17 at 3,414,683 bp
  • A to G, chromosome 17 at 28,777,565 bp
  • A to G, chromosome 17 at 33,941,146 bp
  • G to A, chromosome 18 at 53,685,885 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4368 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041115-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.