Strain Name:
C57BL/6J-MtgxR4388Btlr/Mmmh
Stock Number:
041125-MU
Citation ID:
RRID:MMRRC_041125-MU
Other Names:
R4388 (G1), C57BL/6J-MtgxR4388Btlr
Major Collection:

Strain Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: Kv3.1, KV4, NGK2, KShIIIB, Kcr2-1, Shaw, C230009H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Sft2d1
Name: SFT2 domain containing 1
Synonyms: 5630401J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106489
Homologene: 34525
Slc25a16
Name: solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
Synonyms: HGT.1, ML7, 3110021G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73132
Homologene: 21858
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215476
Homologene: 65866
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: skNAC, LOC380777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22290
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208263
Homologene: 9208
Cd209b
Name: CD209b antigen
Synonyms: SIGNR1, mSIGNR1, 1810030I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69165
Homologene: 84858
Galnt2
Name: polypeptide N-acetylgalactosaminyltransferase 2
Synonyms: ppGaNTase-T2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 108148
HGNC: HGNC:4124
Homologene: 3297
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Mll2, Wbp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Itih-1, Intin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: Spi2-2, Spi2.2, Spi2/eb.4, antitrypsin, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72371
Homologene: 89234
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Pex26
Name: peroxisomal biogenesis factor 26
Synonyms: 4632428M11Rik, peroxisome biogenesis factor 26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74043
Homologene: 9922
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Kng1
Name: kininogen 1
Synonyms: L-kininogen, H-kininigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Cldn20
Name: claudin 20
Synonyms: EG621628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 621628
VEGA: 17
HGNC: HGNC:2042
Homologene: 47972
Ttll2
Name: tubulin tyrosine ligase-like family, member 2
Synonyms: EG625850
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100216474
VEGA: 17
Homologene: 12917
Arpc4
Name: actin related protein 2/3 complex, subunit 4
Synonyms: 5330419I20Rik, p20-Arc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68089
Homologene: 4177
Gm12666
Name: predicted gene 12666
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68280
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 72,330,030 bp
  • T to C, chromosome 1 at 156,018,225 bp
  • A to G, chromosome 4 at 58,069,249 bp
  • T to C, chromosome 4 at 88,603,109 bp
  • A to T, chromosome 4 at 92,191,114 bp
  • T to A, chromosome 5 at 16,614,943 bp
  • A to G, chromosome 5 at 32,829,254 bp
  • A to G, chromosome 5 at 110,588,391 bp
  • A to G, chromosome 6 at 113,385,497 bp
  • A to G, chromosome 6 at 113,556,368 bp
  • A to G, chromosome 6 at 121,184,392 bp
  • A to G, chromosome 7 at 23,301,477 bp
  • A to G, chromosome 7 at 23,321,227 bp
  • A to C, chromosome 7 at 30,588,590 bp
  • C to A, chromosome 7 at 46,397,702 bp
  • A to G, chromosome 7 at 68,170,009 bp
  • A to G, chromosome 8 at 3,925,960 bp
  • T to C, chromosome 8 at 124,295,453 bp
  • G to A, chromosome 9 at 54,396,267 bp
  • T to C, chromosome 10 at 62,928,326 bp
  • T to C, chromosome 10 at 83,513,622 bp
  • T to C, chromosome 10 at 128,044,792 bp
  • C to A, chromosome 12 at 69,845,809 bp
  • C to A, chromosome 12 at 104,411,357 bp
  • T to A, chromosome 13 at 77,316,574 bp
  • T to C, chromosome 13 at 81,581,709 bp
  • A to G, chromosome 14 at 30,941,555 bp
  • A to G, chromosome 15 at 76,705,958 bp
  • C to T, chromosome 15 at 98,853,626 bp
  • T to A, chromosome 16 at 23,079,318 bp
  • G to A, chromosome 17 at 3,533,210 bp
  • T to A, chromosome 17 at 7,351,200 bp
  • A to G, chromosome 17 at 8,320,637 bp
  • A to G, chromosome Y at 1,151,956 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4388 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041125-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.