Strain Name:
C57BL/6J-MtgxR4393Btlr/Mmmh
Stock Number:
041128-MU
Citation ID:
RRID:MMRRC_041128-MU
Other Names:
R4393 (G1), C57BL/6J-MtgxR4393Btlr
Major Collection:

Gene Information

Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75420
Homologene: 11415
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 353047
Homologene: 8871
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik, d1401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Cep68
Name: centrosomal protein 68
Synonyms: 6030463E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216543
Homologene: 65235
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Immt
Name: inner membrane protein, mitochondrial
Synonyms: P87/89, P89, P87, HMP, 1700082C19Rik, D830041H16Rik, mitofilin, Micos60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76614
HGNC: HGNC:6047
Homologene: 38234
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D3Bwg0878e, D11Ertd730e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193116
Homologene: 4690
Kctd2
Name: potassium channel tetramerisation domain containing 2
Synonyms: 2310012I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70382
Homologene: 82389
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 65102
Homologene: 5881
Gpbp1l1
Name: GC-rich promoter binding protein 1-like 1
Synonyms: 5330440M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77110
Homologene: 84840
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Synonyms: Ad4BP, SF1, SF-1, Ftz-F1, steroidogenic factor 1, adrenal 4-binding protein, ELP, Ftzf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26423
HGNC: HGNC:7983
Homologene: 3638
Kcnip2
Name: Kv channel-interacting protein 2
Synonyms: KChIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 80906
Homologene: 23710
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Ebf3
Name: early B cell factor 3
Synonyms: O/E-2, Olf-1/EBF-like 2, 3110018A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13593
Homologene: 56472
Fam3b
Name: FAM3 metabolism regulating signaling molecule B
Synonyms: D16Jhu19e, 9030624C24Rik, ORF9, Pander
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52793
HGNC: HGNC:1253
Homologene: 10766
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77264
Homologene: 3723
Tmem51
Name: transmembrane protein 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214359
Homologene: 9966
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
2410017I17Rik
Name: RIKEN cDNA 2410017I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 675325
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Casc1
Name: cancer susceptibility candidate 1
Synonyms: Las1, A230084G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320662
Homologene: 41242
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Gm9581
Name: predicted gene 9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Dll1
Name: delta like canonical Notch ligand 1
Synonyms: Delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13388
HGNC: HGNC:2908
Homologene: 4104
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Ece2
Name: endothelin converting enzyme 2
Synonyms: 6330509A19Rik, 9630025D12Rik, 1810009K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107522
Homologene: 56679
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224022
Homologene: 20883
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Slc35d3
Name: solute carrier family 35, member D3
Synonyms: 6230421J19Rik, Frcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76157
VEGA: 10
Homologene: 19123
Or10q1b
Name: olfactory receptor family 10 subfamily Q member 1B
Synonyms: GA_x6K02T2RE5P-4037809-4038768, MOR266-8, Olfr1491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258342
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Prrt3
Name: proline-rich transmembrane protein 3
Synonyms: B230206N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 210673
Homologene: 52099
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106618
Homologene: 27066
Cyp26c1
Name: cytochrome P450, family 26, subfamily c, polypeptide 1
Synonyms: EG546726
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 546726
VEGA: 19
Homologene: 28089
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Tgtp1
Name: T cell specific GTPase 1
Synonyms: Mg21, Gtp2, Tgtp, Irgb6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21822
Homologene: 129991
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: UGT1.6, Ugt1a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94284
Homologene: 85959
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: 1200011I03Rik, Mamdc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74762
Homologene: 17780
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clcnk1l, Clck2, Clcnk2, ClC-K2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56365
HGNC: HGNC:2027
Homologene: 107317
Teddm1a
Name: transmembrane epididymal protein 1A
Synonyms: e9-1, Epdd1, Teddm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240819
Homologene: 82370
Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms: XPB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13872
HGNC: HGNC:3435
Homologene: 96
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269209
Homologene: 49432
Hyou1
Name: hypoxia up-regulated 1
Synonyms: CBP-140, Orp150, 140 kDa, Grp170, Cab140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12282
Homologene: 4658
Msl2
Name: MSL complex subunit 2
Synonyms: E130103E02Rik, Rnf184, Msl2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77853
Homologene: 10021
Sgms2
Name: sphingomyelin synthase 2
Synonyms: 4933405A16Rik, 5133401H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74442
Homologene: 32705
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320452
Homologene: 27943
4930433N12Rik
Name: RIKEN cDNA 4930433N12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114673
Or5w1b
Name: olfactory receptor family 5 subfamily W member 1B
Synonyms: GA_x6K02T2Q125-49151278-49150337, MOR176-2, Olfr1133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258348
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67370
Homologene: 23514
Ccl27a
Name: chemokine (C-C motif) ligand 27A
Synonyms: mILC, ESkine, CTACK, Scya27a, CTAK, ILC, ALP, skinskine, Scya27, PESKY, ESkine, Ccl27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20301
Homologene: 134761
Adgrg4
Name: adhesion G protein-coupled receptor G4
Synonyms: LOC236798, PGR17, Gpr112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236798
Homologene: 72131
BC068157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Gm20528
Name: predicted gene 20528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm21738
Name: predicted gene, 21738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Zdhhc21
Name: zinc finger, DHHC domain containing 21
Synonyms: 9130404H11Rik, D130004H04Rik, dep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68268
Homologene: 32668
Gm6408
Name: predicted gene 6408
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 623198
Homologene: 86127
Gm4831
Name: predicted gene 4831
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,045,178 bp
  • C to A, chromosome 1 at 58,467,650 bp
  • T to C, chromosome 1 at 74,572,060 bp
  • T to C, chromosome 1 at 74,622,219 bp
  • CAGAGAGAGAGAGA to CAGAGAGAGAGA, chromosome 1 at 88,211,984 bp
  • C to T, chromosome 1 at 88,215,123 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • A to G, chromosome 1 at 88,266,561 bp
  • T to C, chromosome 1 at 105,522,026 bp
  • G to T, chromosome 1 at 153,892,446 bp
  • A to T, chromosome 2 at 22,577,854 bp
  • T to C, chromosome 2 at 38,694,219 bp
  • A to T, chromosome 2 at 82,256,921 bp
  • A to T, chromosome 2 at 87,645,912 bp
  • A to T, chromosome 3 at 131,341,817 bp
  • C to T, chromosome 4 at 32,754,482 bp
  • T to C, chromosome 4 at 41,768,577 bp
  • A to G, chromosome 4 at 82,847,654 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • C to T, chromosome 4 at 116,554,767 bp
  • A to G, chromosome 4 at 141,412,236 bp
  • T to C, chromosome 4 at 142,031,931 bp
  • A to T, chromosome 5 at 146,482,337 bp
  • A to C, chromosome 6 at 15,377,690 bp
  • T to A, chromosome 6 at 71,872,800 bp
  • A to G, chromosome 6 at 113,494,946 bp
  • T to C, chromosome 6 at 145,194,578 bp
  • C to T, chromosome 7 at 12,492,849 bp
  • A to G, chromosome 7 at 87,001,891 bp
  • C to T, chromosome 7 at 100,305,607 bp
  • C to T, chromosome 7 at 137,225,157 bp
  • G to T, chromosome 8 at 4,214,901 bp
  • T to C, chromosome 8 at 83,938,593 bp
  • C to A, chromosome 9 at 3,134,944 bp
  • T to A, chromosome 9 at 44,381,872 bp
  • A to G, chromosome 9 at 58,844,300 bp
  • A to G, chromosome 9 at 101,101,477 bp
  • T to C, chromosome 10 at 19,849,606 bp
  • G to T, chromosome 10 at 128,572,770 bp
  • G to A, chromosome 11 at 6,316,772 bp
  • A to T, chromosome 11 at 20,238,544 bp
  • T to A, chromosome 11 at 43,439,269 bp
  • C to A, chromosome 11 at 48,987,623 bp
  • A to G, chromosome 11 at 103,376,965 bp
  • T to C, chromosome 11 at 115,429,500 bp
  • G to T, chromosome 11 at 115,993,326 bp
  • A to G, chromosome 13 at 51,654,466 bp
  • G to C, chromosome 14 at 19,417,178 bp
  • T to A, chromosome 14 at 24,177,989 bp
  • T to C, chromosome 14 at 33,932,738 bp
  • T to C, chromosome 16 at 17,574,489 bp
  • T to C, chromosome 16 at 20,632,848 bp
  • C to A, chromosome 16 at 32,754,529 bp
  • A to G, chromosome 16 at 59,560,095 bp
  • C to A, chromosome 16 at 97,481,786 bp
  • G to A, chromosome 17 at 15,370,693 bp
  • A to T, chromosome 17 at 25,853,849 bp
  • T to C, chromosome 17 at 29,850,517 bp
  • C to A, chromosome 17 at 36,161,969 bp
  • T to C, chromosome 17 at 37,114,084 bp
  • T to A, chromosome 18 at 32,265,621 bp
  • C to T, chromosome 18 at 33,891,420 bp
  • T to C, chromosome 19 at 13,705,190 bp
  • G to A, chromosome 19 at 37,686,657 bp
  • A to G, chromosome 19 at 45,812,230 bp
  • C to T, chromosome 19 at 46,371,992 bp
  • T to G, chromosome X at 56,932,343 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4393 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041128-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.