Strain Name:
C57BL/6J-MtgxR4398Btlr/Mmmh
Stock Number:
041130-MU
Citation ID:
RRID:MMRRC_041130-MU
Other Names:
R4398 (G1), C57BL/6J-MtgxR4398Btlr
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: bt, ADAMTS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223838
VEGA: 15
Homologene: 11808
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18213
VEGA: 7
HGNC: HGNC:8033
Homologene: 49183
Pdzd2
Name: PDZ domain containing 2
Synonyms: Gm21706, A930022H17Rik, 4930537L06Rik, LOC223364, Pdzk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68070
VEGA: 15
Homologene: 23393
Efnb2
Name: ephrin B2
Synonyms: Htk-L, LERK-5, Eplg5, ELF-2, Lerk5, Epl5, NLERK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13642
VEGA: 8
HGNC: HGNC:3227
Homologene: 3019
Smad7
Name: SMAD family member 7
Synonyms: Madh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17131
VEGA: 18
HGNC: HGNC:6773
Homologene: 4314
Dmd
Name: dystrophin, muscular dystrophy
Synonyms: Dp427, X-linked muscular dystrophy, pke, Dp71, Duchenne muscular dystrophy, mdx, dys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 13405
VEGA: X
HGNC: HGNC:2928
Homologene: 20856
Prim2
Name: DNA primase, p58 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19076
VEGA: 1
HGNC: HGNC:9370
Homologene: 731
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68964
VEGA: 11
Homologene: 11830
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: Falz, 9430093H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207165
VEGA: 11
HGNC: HGNC:3581
Homologene: 114397
Zfp407
Name: zinc finger protein 407
Synonyms: LOC381139, 6430585N13Rik, LOC240469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240476
VEGA: 18
Homologene: 86402
Stag1
Name: stromal antigen 1
Synonyms: Scc3, SA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20842
VEGA: 9
Homologene: 21191
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
VEGA: 9
HGNC: HGNC:4867
Homologene: 31207
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78893
VEGA: 9
Homologene: 41040
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: Dapper1, Frodo1, Frodo, Frd1, THYEX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 59036
VEGA: 12
Homologene: 9613
Ubn1
Name: ubinuclein 1
Synonyms: 2610108L02Rik, 1110029L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 170644
VEGA: 16
Homologene: 9656
Tsn
Name: translin
Synonyms: TB-RBP, 2610034C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22099
VEGA: 1
Homologene: 3397
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 209018
VEGA: 16
Homologene: 44592
Pgr
Name: progesterone receptor
Synonyms: PR-B, PR-A, PR, ENSMUSG00000074510, NR3C3, 9930019P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18667
VEGA: 9
HGNC: HGNC:8910
Homologene: 713
Mia3
Name: melanoma inhibitory activity 3
Synonyms: 9130229H14Rik, Tango, B230399H06Rik, A930039G15Rik, LOC385255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 338366
VEGA: 1
Homologene: 85165
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: AMPKalpha1, C130083N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231386
VEGA: 5
Homologene: 15796
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14118
VEGA: 2
HGNC: HGNC:3603
Homologene: 30958
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
VEGA: 5
Homologene: 69111
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 667663
VEGA: 2
HGNC: HGNC:7601
Homologene: 49486
Dbn1
Name: drebrin 1
Synonyms: drebrin A, drebrin E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56320
VEGA: 13
HGNC: HGNC:2695
Homologene: 3236
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72772
VEGA: 5
Homologene: 11070
Olfr53
Name: olfactory receptor 53
Synonyms: GA_x6K02T2PBJ9-42798103-42799038, IE12, MOR253-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258962
VEGA: 7
Homologene: 133678
AI661453
Name: expressed sequence AI661453
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224833
VEGA: 17
Homologene: 138294
Zfp521
Name: zinc finger protein 521
Synonyms: Evi3, B930086A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225207
VEGA: 18
Homologene: 9151
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r11, V2r10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 22301
VEGA: 14
Rnf130
Name: ring finger protein 130
Synonyms: 2510042A13Rik, G1RP, G1RZFP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 59044
VEGA: 11
Homologene: 41267
Vmn1r25
Name: vomeronasal 1 receptor 25
Synonyms: V1rc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113865
VEGA: 6
Homologene: 137652
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244418
VEGA: 8
Homologene: 18256
Tenm1
Name: teneurin transmembrane protein 1
Synonyms: teneurin-1, Odz1, Ten-m1, TCAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 23963
VEGA: X
HGNC: HGNC:8117
Homologene: 56542
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: Fam179b, A430041B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 328108
VEGA: 12
Homologene: 15025
Eif4a1
Name: eukaryotic translation initiation factor 4A1
Synonyms: Eif4, initiation factor eIF-4A long form
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13681
VEGA: 11
HGNC: HGNC:3282
Homologene: 103998
Tlr12
Name: toll-like receptor 12
Synonyms: Tlr11, LOC384059
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 384059
VEGA: 4
Homologene: 135964
Klk1b16
Name: kallikrein 1-related peptidase b16
Synonyms: Klk16, mGk-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16615
VEGA: 7
HGNC: HGNC:6364
Homologene: 68141
Khdc1a
Name: KH domain containing 1A
Synonyms: Ndg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 368204
VEGA: 1
Homologene: 134524
Gpr20
Name: G protein-coupled receptor 20
Synonyms: A430106B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239530
VEGA: 15
HGNC: HGNC:4475
Homologene: 3870
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76877
VEGA: 10
HGNC: HGNC:9775
Homologene: 3610
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Diet1, Gm13318, Gm13364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 102635496
VEGA: 2
Homologene: 136214
F730035P03Rik
Name: RIKEN cDNA F730035P03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Tomm6os
Name: translocase of outer mitochondrial membrane 6, opposite strand
Synonyms: Prickle4os, Gm14872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100415787
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 21,350,393 bp
  • A to G, chromosome 1 at 33,512,111 bp
  • C to T, chromosome 1 at 118,311,069 bp
  • A to G, chromosome 1 at 183,330,878 bp
  • C to T, chromosome 2 at 16,150,783 bp
  • T to A, chromosome 2 at 22,577,842 bp
  • C to T, chromosome 2 at 125,397,781 bp
  • T to A, chromosome 4 at 128,616,195 bp
  • A to T, chromosome 5 at 14,775,366 bp
  • T to A, chromosome 5 at 23,794,447 bp
  • T to A, chromosome 5 at 86,815,654 bp
  • G to T, chromosome 5 at 86,835,820 bp
  • A to T, chromosome 6 at 57,978,827 bp
  • A to T, chromosome 7 at 44,141,427 bp
  • A to T, chromosome 7 at 78,250,769 bp
  • A to T, chromosome 7 at 99,780,268 bp
  • T to C, chromosome 7 at 140,652,828 bp
  • C to T, chromosome 8 at 8,620,832 bp
  • A to G, chromosome 8 at 36,103,655 bp
  • T to C, chromosome 9 at 8,903,749 bp
  • T to G, chromosome 9 at 66,479,453 bp
  • A to G, chromosome 9 at 100,956,606 bp
  • T to A, chromosome 9 at 114,631,881 bp
  • G to A, chromosome 10 at 75,044,496 bp
  • T to A, chromosome 11 at 50,071,378 bp
  • C to T, chromosome 11 at 69,022,871 bp
  • T to C, chromosome 11 at 69,669,244 bp
  • T to C, chromosome 11 at 107,110,844 bp
  • A to G, chromosome 12 at 64,980,856 bp
  • T to C, chromosome 12 at 71,317,185 bp
  • T to C, chromosome 13 at 55,475,381 bp
  • T to C, chromosome 14 at 51,452,094 bp
  • A to G, chromosome 15 at 5,177,161 bp
  • A to T, chromosome 15 at 12,375,975 bp
  • G to A, chromosome 15 at 73,696,276 bp
  • C to A, chromosome 15 at 94,333,695 bp
  • A to G, chromosome 16 at 5,064,425 bp
  • T to G, chromosome 16 at 21,504,466 bp
  • G to A, chromosome 16 at 35,268,993 bp
  • G to A, chromosome 17 at 47,468,117 bp
  • A to G, chromosome 17 at 47,690,531 bp
  • C to T, chromosome 18 at 13,846,544 bp
  • T to C, chromosome 18 at 75,394,163 bp
  • G to A, chromosome 18 at 84,562,731 bp
  • G to T, chromosome X at 43,167,683 bp
  • A to C, chromosome X at 83,722,018 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4398 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041130-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.