Strain Name:
C57BL/6J-MtgxR4405Btlr/Mmmh
Stock Number:
041134-MU
Citation ID:
RRID:MMRRC_041134-MU
Other Names:
R4405 (G1), C57BL/6J-MtgxR4405Btlr
Major Collection:

Strain Information

Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2010009L17Rik, 2310029P06Rik, VG5Q
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22036
Homologene: 31343
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: multifunctional protein 2, MFP2, 17[b]-HSD, MFE-2, perMFE-2, Mfp-2, D-bifunctional protein
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: 9530001P15Rik, Ponsin, 2310065E01Rik, Sh3d5, c-Cbl-associated protein, CAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, jdf2, D15F32S1h, D7H15F32S1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Klf3
Name: Kruppel-like transcription factor 3 (basic)
Synonyms: Bklf, Tef-2, 9930027G08Rik, BKLF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16599
Homologene: 7396
Zwint
Name: ZW10 interactor
Synonyms: 2010007E07Rik, 2600001N01Rik, D10Ertd749e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52696
Homologene: 48496
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabp3, Fabph1, Mdgi, Fabph-1, Fabph4, Fabph-4, H-FABP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nobq1, 1110062G02Rik, Nob1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57915
Homologene: 56856
Etv6
Name: ets variant 6
Synonyms: Tel, translocation-ets-leukemia
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14011
HGNC: HGNC:3495
Homologene: 37560
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: Tob3, 2400004H09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108888
Homologene: 10059
E2f5
Name: E2F transcription factor 5
Synonyms: E2F-5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13559
HGNC: HGNC:3119
Homologene: 1472
Slc25a36
Name: solute carrier family 25, member 36
Synonyms: C330005L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 192287
Homologene: 10039
Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: 9530052P13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225028
VEGA: 17
HGNC: HGNC:6865
Homologene: 2683
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: BC002230, 6720454P05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Myof
Name: myoferlin
Synonyms: E030042N20Rik, Fer1l3, 2310051D19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Oca2
Name: oculocutaneous albinism II
Synonyms: p, D7H15S12, D7H15S12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Kcna10
Name: potassium voltage-gated channel, shaker-related subfamily, member 10
Synonyms: Kcna8, Kv1.8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242151
HGNC: HGNC:6219
Homologene: 4054
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Gucy2g
Name: guanylate cyclase 2g
Synonyms: GC-G, 2410077I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Snip1
Name: Smad nuclear interacting protein 1
Synonyms: 2410133M08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76793
Homologene: 110886
Grb14
Name: growth factor receptor bound protein 14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50915
HGNC: HGNC:4565
Homologene: 3303
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244179
Homologene: 17034
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434017
Homologene: 79462
Cpb1
Name: carboxypeptidase B1
Synonyms: 2210008M23Rik, 0910001A18Rik, 1810063F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54672
Homologene: 18129
Pop5
Name: processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
Synonyms: 2700077E03Rik, 1500019J17Rik, Rnasep3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117109
Homologene: 41076
Noa1
Name: nitric oxide associated 1
Synonyms: mAtNOS1, 2610024G14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56412
Homologene: 10518
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Dnm1
Name: dynamin 1
Synonyms: Ftfl, dynamin 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: SAST170, SAST, 9430008B02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: D19Ertd652e, 4930463G05Rik, 4930428C11Rik, 4632415N18Rik, Wdr96
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: YSPL3, Slc23a1, SVCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54338
Homologene: 68440
Rita1
Name: RBPJ interacting and tubulin associated 1
Synonyms: 1110008J03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100764
Homologene: 12585
Sec61a2
Name: SEC61 translocon subunit alpha 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57743
Homologene: 38481
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: Kst1, 2010013B02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233836
Homologene: 14184
Or2ag1
Name: olfactory receptor family 2 subfamily AG member 1
Synonyms: MOR283-2, GA_x6K02T2PBJ9-9256348-9255398, Olfr705
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259034
Homologene: 128075
Lancl1
Name: LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms: LanC-like protein 1, Gpr69a, p40
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14768
HGNC: HGNC:6508
Homologene: 4417
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Ldaf1
Name: lipid droplet assembly factor 1
Synonyms: 8430420C20Rik, Tmem159
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233806
Homologene: 10705
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66868
Homologene: 11228
Or7a41
Name: olfactory receptor family 7 subfamily A member 41
Synonyms: GA_x6K02T2QGN0-2777431-2776472, IF12, Olfr57, MOR139-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18357
Homologene: 133620
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: 4933405P08Rik, SPEER-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71026
Homologene: 69402
Cd8b1
Name: CD8 subunit beta 1
Synonyms: Lyt-3, Ly-3, Ly-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12526
Homologene: 3621
Mbl2
Name: mannose-binding lectin (protein C) 2
Synonyms: MBP-C, MBL-C, MBL
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17195
VEGA: 19
HGNC: HGNC:6922
Homologene: 110436
Igkv9-129
Name: immunoglobulin kappa variable 9-129
Synonyms: immunoglobulin kappa light chain
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692182
Gm13334
Name: predicted gene 13334
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm13068
Name: predicted gene 13068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Mir7658
Name: microRNA 7658
Synonyms: mmu-mir-7658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 102466236
VEGA: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 24,534,109 bp
  • A to T, chromosome 1 at 67,020,856 bp
  • T to C, chromosome 1 at 89,968,689 bp
  • T to C, chromosome 2 at 5,882,859 bp
  • A to T, chromosome 2 at 10,106,737 bp
  • G to A, chromosome 2 at 13,466,030 bp
  • C to T, chromosome 2 at 18,698,943 bp
  • A to G, chromosome 2 at 32,335,972 bp
  • C to T, chromosome 2 at 34,728,735 bp
  • T to C, chromosome 2 at 64,953,622 bp
  • T to A, chromosome 2 at 91,155,625 bp
  • A to G, chromosome 2 at 132,075,460 bp
  • T to A, chromosome 3 at 14,603,763 bp
  • T to A, chromosome 3 at 20,263,569 bp
  • G to C, chromosome 3 at 67,600,610 bp
  • A to G, chromosome 3 at 95,068,059 bp
  • G to A, chromosome 3 at 107,195,465 bp
  • G to T, chromosome 4 at 125,068,186 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to G, chromosome 4 at 149,749,083 bp
  • A to G, chromosome 4 at 155,749,118 bp
  • A to T, chromosome 4 at 156,225,273 bp
  • C to G, chromosome 5 at 13,796,380 bp
  • T to C, chromosome 5 at 64,173,670 bp
  • A to T, chromosome 5 at 64,829,004 bp
  • A to T, chromosome 5 at 77,306,372 bp
  • G to A, chromosome 5 at 105,051,062 bp
  • C to T, chromosome 5 at 115,240,777 bp
  • A to T, chromosome 5 at 120,602,420 bp
  • A to G, chromosome 6 at 57,432,057 bp
  • T to A, chromosome 6 at 67,839,800 bp
  • C to T, chromosome 6 at 71,326,022 bp
  • T to C, chromosome 6 at 73,129,291 bp
  • T to A, chromosome 6 at 115,849,115 bp
  • A to G, chromosome 6 at 134,233,534 bp
  • T to A, chromosome 7 at 56,170,477 bp
  • G to T, chromosome 7 at 56,414,434 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • T to A, chromosome 7 at 106,873,373 bp
  • T to G, chromosome 7 at 120,115,491 bp
  • A to T, chromosome 7 at 123,258,477 bp
  • C to T, chromosome 8 at 18,632,541 bp
  • C to A, chromosome 8 at 84,920,891 bp
  • C to T, chromosome 8 at 95,036,908 bp
  • A to G, chromosome 9 at 57,139,083 bp
  • A to T, chromosome 9 at 79,639,965 bp
  • T to C, chromosome 9 at 97,085,118 bp
  • G to T, chromosome 9 at 107,963,394 bp
  • T to C, chromosome 10 at 51,628,543 bp
  • T to C, chromosome 10 at 72,656,263 bp
  • A to T, chromosome 10 at 79,035,410 bp
  • T to C, chromosome 10 at 126,011,008 bp
  • A to G, chromosome 12 at 100,130,584 bp
  • A to T, chromosome 13 at 76,155,665 bp
  • G to A, chromosome 13 at 95,371,594 bp
  • C to T, chromosome 14 at 103,123,445 bp
  • A to G, chromosome 17 at 80,615,015 bp
  • G to T, chromosome 18 at 50,128,314 bp
  • T to A, chromosome 19 at 30,239,516 bp
  • A to G, chromosome 19 at 37,922,978 bp
  • T to C, chromosome 19 at 40,395,745 bp
  • C to T, chromosome 19 at 47,739,797 bp
  • A to T, chromosome 19 at 55,237,837 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4405 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041134-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.