Strain Name:
C57BL/6J-MtgxR4412Btlr/Mmmh
Stock Number:
041135-MU
Citation ID:
RRID:MMRRC_041135-MU
Other Names:
R4412 (G1), C57BL/6J-MtgxR4412Btlr
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Npr3
Name: natriuretic peptide receptor 3
Synonyms: NPR-C, Nppc receptor, B430320C24Rik, lgj, longjohn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Gpr21
Name: G protein-coupled receptor 21
Synonyms: C230004C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 338346
HGNC: HGNC:4476
Homologene: 74546
Nisch
Name: nischarin
Synonyms: edsn, 3202002H23Rik, 1200007D05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Tex264
Name: testis expressed gene 264 ER-phagy receptor
Synonyms: TEG-264
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21767
Homologene: 7975
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: SRm300, 5033413A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75956
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: 2610016F01Rik, Tnrc15, A830080H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227331
Homologene: 41048
Dnajc14
Name: DnaJ heat shock protein family (Hsp40) member C14
Synonyms: DRIP78, LIP6, HDJ3, 5730551F12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74330
VEGA: 10
Homologene: 12553
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Eipr1
Name: EARP complex and GARP complex interacting protein 1
Synonyms: Tssc1, D12Ertd604e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380752
VEGA: 12
Homologene: 2481
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: ATP-dependent metalloprotease FtsH1, Ftsh
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27377
Homologene: 31996
Rpp30
Name: ribonuclease P/MRP 30 subunit
Synonyms: TSG15, Rnasep2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54364
VEGA: 19
Homologene: 38180
Snx9
Name: sorting nexin 9
Synonyms: SDP1, SH3PX1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72333
Homologene: 75052
Khdc3
Name: KH domain containing 3, subcortical maternal complex member
Synonyms: ecat1, FILIA, 2410004A20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66991
Homologene: 49842
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Sohlh2
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2
Synonyms: 4933406N12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74434
Homologene: 9864
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Pcdhb10
Name: protocadherin beta 10
Synonyms: PcdhbJ, Pcdhb5D
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93881
HGNC: HGNC:8690
Homologene: 88834
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: phenobarbitol inducible, type a, Cyp2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13094
HGNC: HGNC:2615
Homologene: 74933
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218865
Homologene: 41261
Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms: CCK, D4Bwg0615e, CARDIAK, RIP2, RICK, CARD3, 2210420D18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192656
Homologene: 37856
Npr2
Name: natriuretic peptide receptor 2
Synonyms: cn, guanylyl cyclase-B, pwe
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Cpne9
Name: copine family member IX
Synonyms: A730016F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211232
Homologene: 84686
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Vmn1r115
Name: vomeronasal 1 receptor 115
Synonyms: Gm8549
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667273
Homologene: 104166
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: D330008N11Rik, Arh2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Gsdmc3
Name: gasdermin C3
Synonyms: 9930109F21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 270328
HGNC: HGNC:7151
Homologene: 69487
Alpl
Name: alkaline phosphatase, liver/bone/kidney
Synonyms: ALP, Akp2, TNSALP, Akp-2, TNAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11647
HGNC: HGNC:438
Homologene: 37314
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230587
Homologene: 77390
Or4c1
Name: olfactory receptor family 4 subfamily C member 1
Synonyms: Olfr1231, GA_x6K02T2Q125-50748233-50747292, MOR235-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258446
Homologene: 27168
Podnl1
Name: podocan-like 1
Synonyms: 5832418A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244550
Homologene: 41590
E330020D12Rik
Name: Riken cDNA E330020D12 gene
Synonyms: Gm6648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 626058
Kifc5c-ps
Name: kinesin family member C5C, pseudogene
Synonyms: Kifc5c, kinesin family c-terminal 5C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 94118
Ms4a12
Name: membrane-spanning 4-domains, subfamily A, member 12
Synonyms: LOC381213
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381213
Homologene: 130690
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 87,436,860 bp
  • A to C, chromosome 1 at 153,408,402 bp
  • G to A, chromosome 2 at 23,175,187 bp
  • C to G, chromosome 2 at 37,517,432 bp
  • A to G, chromosome 2 at 89,303,340 bp
  • A to T, chromosome 2 at 112,335,888 bp
  • A to T, chromosome 3 at 19,966,353 bp
  • C to A, chromosome 3 at 55,197,002 bp
  • A to G, chromosome 4 at 16,124,511 bp
  • G to A, chromosome 4 at 43,644,150 bp
  • A to G, chromosome 4 at 107,634,718 bp
  • A to G, chromosome 4 at 137,758,628 bp
  • T to A, chromosome 5 at 130,335,232 bp
  • A to G, chromosome 6 at 113,290,001 bp
  • A to C, chromosome 7 at 10,050,308 bp
  • C to T, chromosome 7 at 20,844,282 bp
  • T to G, chromosome 7 at 26,198,443 bp
  • T to C, chromosome 8 at 13,246,114 bp
  • T to A, chromosome 8 at 25,641,214 bp
  • T to C, chromosome 8 at 45,023,599 bp
  • A to G, chromosome 8 at 61,687,372 bp
  • C to T, chromosome 8 at 72,739,779 bp
  • A to T, chromosome 8 at 84,130,665 bp
  • C to T, chromosome 8 at 110,415,736 bp
  • C to T, chromosome 9 at 21,399,560 bp
  • A to G, chromosome 9 at 73,102,874 bp
  • C to A, chromosome 9 at 106,682,078 bp
  • G to C, chromosome 10 at 117,595,864 bp
  • G to T, chromosome 10 at 128,806,205 bp
  • T to C, chromosome 11 at 118,073,683 bp
  • A to T, chromosome 12 at 28,859,373 bp
  • T to A, chromosome 12 at 76,106,060 bp
  • A to C, chromosome 12 at 76,577,764 bp
  • G to A, chromosome 12 at 95,780,273 bp
  • G to T, chromosome 14 at 30,031,715 bp
  • A to G, chromosome 14 at 31,186,658 bp
  • G to C, chromosome 15 at 11,905,149 bp
  • A to G, chromosome 15 at 63,866,796 bp
  • T to C, chromosome 15 at 74,577,453 bp
  • C to T, chromosome 17 at 5,908,394 bp
  • A to G, chromosome 17 at 23,810,468 bp
  • TC to T, chromosome 18 at 37,414,141 bp
  • A to G, chromosome 18 at 49,848,761 bp
  • T to C, chromosome 19 at 11,230,443 bp
  • T to A, chromosome 19 at 36,100,255 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4412 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041135-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.