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Strain Name:
C57BL/6J-MtgxR4418Btlr/Mmmh
Stock Number:
041139-MU
Citation ID:
RRID:MMRRC_041139-MU
Other Names:
R4418 (G1), C57BL/6J-MtgxR4418Btlr
Major Collection:

Strain Information

Gpr6
Name: G protein-coupled receptor 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140741
VEGA: 10
HGNC: HGNC:4515
Homologene: 38026
Pecam1
Name: platelet/endothelial cell adhesion molecule 1
Synonyms: PECAM-1, Cd31
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18613
HGNC: HGNC:8823
Homologene: 47925
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Mrpl39
Name: mitochondrial ribosomal protein L39
Synonyms: MRP-L5, Rpml5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27393
Homologene: 9679
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: 9930121L06Rik, Artemis, Art
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227525
Homologene: 32547
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Wasf1
Name: WASP family, member 1
Synonyms: WAVE-1, Scar, WAVE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83767
Homologene: 2920
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Psma3
Name: proteasome subunit alpha 3
Synonyms: Lmpc8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19167
HGNC: HGNC:9532
Homologene: 2082
Ipo5
Name: importin 5
Synonyms: RanBP5, 5730478E03Rik, 1110011C18Rik, Kpnb3, IMB3, importin beta 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Drg2
Name: developmentally regulated GTP binding protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13495
HGNC: HGNC:3030
Homologene: 1061
B3gnt3
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Synonyms: 2210008L19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72297
Homologene: 113516
Rnf167
Name: ring finger protein 167
Synonyms: 0610010G05Rik, 5730408C10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70510
Homologene: 41046
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: RING4, PSF-1, MTP1, Tap-1, Ham-1, Ham1, Abcb2, TAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Homer1
Name: homer scaffolding protein 1
Synonyms: Ves-1, PSD-Zip45
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26556
Homologene: 3155
Dctn2
Name: dynactin 2
Synonyms: RBP50, DCTN-50, p50, 2310042E05Rik, C130077D06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Hs6st1
Name: heparan sulfate 6-O-sulfotransferase 1
Synonyms: 6OST1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50785
HGNC: HGNC:5201
Homologene: 75051
Dync1li1
Name: dynein cytoplasmic 1 light intermediate chain 1
Synonyms: LIC-1, 1110053F02Rik, Dnclic1, Dlic1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235661
VEGA: 9
Homologene: 9403
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
D030028A08Rik
Name: RIKEN cDNA D030028A08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319371
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Kcnk2
Name: potassium channel, subfamily K, member 2
Synonyms: TREK-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16526
HGNC: HGNC:6277
Homologene: 7794
Ppp2cb
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms: D8Ertd766e, PP2Ac
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19053
HGNC: HGNC:9300
Homologene: 37889
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Gbgt1
Name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227671
Homologene: 110677
Zfp120
Name: zinc finger protein 120
Synonyms: MZF31, E030042N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104348
Homologene: 138454
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: LOC380730, Gm884
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20460
Homologene: 2283
Ifitm6
Name: interferon induced transmembrane protein 6
Synonyms: fragilis5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213002
Homologene: 72556
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74338
Homologene: 52819
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Hnf4g
Name: hepatocyte nuclear factor 4, gamma
Synonyms: NR2A2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30942
HGNC: HGNC:5026
Homologene: 37886
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Synonyms: Ugt3a, Ugt3a1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105887
Homologene: 122787
Dele1
Name: DAP3 binding cell death enhancer 1
Synonyms: 0610009O20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66839
VEGA: 18
Homologene: 32232
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Kcr1-1, Shab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243043
Homologene: 18464
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: Obph1, ORP5, 1110006M06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79196
Homologene: 98024
Rpl21-ps4
Name: ribosomal protein L21, pseudogene 4
Synonyms: Gm5201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 382843
VEGA: 14
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Mmp25
Name: matrix metallopeptidase 25
Synonyms: Leukolysin, MT6-MMP, F730048C11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240047
VEGA: 17
Homologene: 23375
Gm5884
Name: predicted pseudogene 5884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545878
Opn1sw
Name: opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
Synonyms: Blue/UV Opsin, Blue Opsin, SWS opsin, Short Wavelength Sensitive opsin, S Opsin, Blue Cone Opsin, Bcp, UV cone pigment
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12057
HGNC: HGNC:1012
Homologene: 1291
Klhdc2
Name: kelch domain containing 2
Synonyms: HCLP-1, 2310022K15Rik, D12Ertd522e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69554
Homologene: 8631
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228536
Homologene: 8976
Pacc1
Name: proton activated chloride channel 1
Synonyms: 2310028N02Rik, Tmem206
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66950
Homologene: 10097
Chad
Name: chondroadherin
Synonyms: SLRR4A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12643
HGNC: HGNC:1909
Homologene: 36063
Chil4
Name: chitinase-like 4
Synonyms: Ym2, Chi3l4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 104183
Homologene: 74931
4930523C07Rik
Name: RIKEN cDNA 4930523C07 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67647
Homologene: 124386
Mgat1
Name: mannoside acetylglucosaminyltransferase 1
Synonyms: Mgat-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17308
HGNC: HGNC:7044
Homologene: 1804
Ap3s1-ps2
Name: adaptor-related protein complex 3, sigma 1 subunit, pseudogene 2
Synonyms: Ap3s1-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434339
H2bc4
Name: H2B clustered histone 4
Synonyms: 2610022J01Rik, H2bfs, Hist1h2bc
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68024
Homologene: 135944
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,104,027 bp
  • A to G, chromosome 1 at 160,044,802 bp
  • G to A, chromosome 1 at 189,256,727 bp
  • T to A, chromosome 1 at 191,348,432 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • T to C, chromosome 2 at 3,452,935 bp
  • A to G, chromosome 2 at 28,498,408 bp
  • A to T, chromosome 2 at 76,889,481 bp
  • A to T, chromosome 2 at 104,789,421 bp
  • C to T, chromosome 2 at 112,831,224 bp
  • G to A, chromosome 2 at 118,922,523 bp
  • A to T, chromosome 2 at 125,752,915 bp
  • A to G, chromosome 2 at 150,118,185 bp
  • C to A, chromosome 2 at 167,105,675 bp
  • A to G, chromosome 3 at 3,648,094 bp
  • G to A, chromosome 3 at 106,203,727 bp
  • A to G, chromosome 4 at 115,009,377 bp
  • T to C, chromosome 4 at 145,536,728 bp
  • T to C, chromosome 5 at 69,341,162 bp
  • A to T, chromosome 5 at 150,048,800 bp
  • G to A, chromosome 6 at 29,379,424 bp
  • C to A, chromosome 6 at 128,645,159 bp
  • A to G, chromosome 7 at 131,222,708 bp
  • A to T, chromosome 7 at 131,247,465 bp
  • A to T, chromosome 7 at 141,016,071 bp
  • A to T, chromosome 7 at 143,709,815 bp
  • G to A, chromosome 8 at 33,617,049 bp
  • T to C, chromosome 8 at 61,106,864 bp
  • T to C, chromosome 8 at 71,693,769 bp
  • A to T, chromosome 8 at 94,405,293 bp
  • C to A, chromosome 8 at 109,530,633 bp
  • T to A, chromosome 9 at 55,838,180 bp
  • C to T, chromosome 9 at 58,843,895 bp
  • G to T, chromosome 9 at 88,582,153 bp
  • T to A, chromosome 9 at 114,706,170 bp
  • C to T, chromosome 10 at 40,936,582 bp
  • T to G, chromosome 10 at 41,070,608 bp
  • T to A, chromosome 10 at 76,718,405 bp
  • G to T, chromosome 10 at 78,217,188 bp
  • T to G, chromosome 10 at 127,091,650 bp
  • T to G, chromosome 10 at 127,278,365 bp
  • A to T, chromosome 10 at 128,728,094 bp
  • A to G, chromosome 11 at 49,261,245 bp
  • A to C, chromosome 11 at 60,468,146 bp
  • T to A, chromosome 11 at 70,647,917 bp
  • C to T, chromosome 11 at 94,567,837 bp
  • A to T, chromosome 11 at 96,940,969 bp
  • T to C, chromosome 11 at 103,618,314 bp
  • A to G, chromosome 11 at 106,695,922 bp
  • C to T, chromosome 12 at 69,307,597 bp
  • G to A, chromosome 12 at 70,978,753 bp
  • C to T, chromosome 13 at 23,684,503 bp
  • A to G, chromosome 13 at 73,684,395 bp
  • A to G, chromosome 13 at 93,402,069 bp
  • C to T, chromosome 13 at 100,300,600 bp
  • A to G, chromosome 14 at 11,227,879 bp
  • T to A, chromosome 14 at 43,748,845 bp
  • G to T, chromosome 14 at 51,418,081 bp
  • A to G, chromosome 14 at 52,136,754 bp
  • T to G, chromosome 14 at 120,943,893 bp
  • T to A, chromosome 15 at 9,279,980 bp
  • C to A, chromosome 16 at 84,725,124 bp
  • A to T, chromosome 17 at 20,583,689 bp
  • T to A, chromosome 17 at 23,644,070 bp
  • T to A, chromosome 17 at 34,188,379 bp
  • C to T, chromosome 18 at 37,343,482 bp
  • T to C, chromosome 18 at 38,261,287 bp
  • T to C, chromosome 18 at 86,404,856 bp
  • T to C, chromosome 19 at 23,979,435 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4418 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041139-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.