Strain Name:
C57BL/6J-MtgxR4419Btlr/Mmmh
Stock Number:
041140-MU
Citation ID:
RRID:MMRRC_041140-MU
Other Names:
R4419 (G1), C57BL/6J-MtgxR4419Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: D12Ertd7e, 1110006F08Rik, Dicer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 192119
VEGA: 12
Homologene: 13251
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20269
Homologene: 56005
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269424
Homologene: 18162
B4galt1
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms: B-1,4-GalT1, b1,4-Galactosyltransferase I, beta 1,4-Galactosyltransferase I, Ggtb2, Ggtb, beta-1,4-GalT1, GalT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14595
HGNC: HGNC:924
Homologene: 20378
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22241
Homologene: 2640
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Nmt1
Name: N-myristoyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18107
HGNC: HGNC:7857
Homologene: 69027
Ss18
Name: SS18, nBAF chromatin remodeling complex subunit
Synonyms: Ssxt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 268996
VEGA: 18
Homologene: 38080
Arfip2
Name: ADP-ribosylation factor interacting protein 2
Synonyms: 2310002N04Rik, Arfaptin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76932
Homologene: 8234
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: jcpk, Bic-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 83675
Homologene: 12856
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, 2300002E22Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Lctl
Name: lactase-like
Synonyms: E130104I05Rik, KLPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235435
Homologene: 70710
Rras
Name: related RAS viral (r-ras) oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20130
Homologene: 4565
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Tmprss14, Prss14, Epithin, matriptase, MT-SP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19143
Homologene: 7906
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: erythroid, Spna1, Spna-1, ihj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20739
Homologene: 74460
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Birc1b, Naip-rs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239420
Homologene: 65982
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 140579
Homologene: 44338
Duox1
Name: dual oxidase 1
Synonyms: THOX1, 9930101G15Rik, NOXEF1, LNOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: Aof1, 4632428N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218214
Homologene: 14695
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268932
VEGA: 17
Homologene: 25873
D2hgdh
Name: D-2-hydroxyglutarate dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98314
Homologene: 5534
Gm5546
Name: predicted gene 5546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 433634
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 9530025L16Rik, 5530401I02Rik, 4632417D23Rik, LOC268884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77446
Homologene: 35276
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 268816
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: flamingo, Fmi1, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17837
Homologene: 136663
Med16
Name: mediator complex subunit 16
Synonyms: Thrap5, 95kDa, Trap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216154
Homologene: 64602
Olfr1328
Name: olfactory receptor 1328
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-13, MOR259-1, Olfr1519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 258394
Homologene: 121524
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: 2900042E17Rik, Zip10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227059
Homologene: 34076
Ky
Name: kyphoscoliosis peptidase
Synonyms: D9Mgc44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16716
Homologene: 11506
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113847
Homologene: 130651
Olfr916
Name: olfactory receptor 916
Synonyms: MOR168-1, GA_x6K02T2PVTD-32360710-32359778
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258780
VEGA: 9
Homologene: 74147
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Orct2, Oct2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20518
VEGA: 17
Homologene: 68293
Olfr780
Name: olfactory receptor 780
Synonyms: MOR114-12, GA_x6K02T2PULF-11002360-11003298
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258281
Homologene: 133586
Amdhd2
Name: amidohydrolase domain containing 2
Synonyms: 5730457F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 245847
Homologene: 9311
Mettl17
Name: methyltransferase like 17
Synonyms: Mett11d1, D14Ertd209e, 2310032K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 52535
Homologene: 11226
Trafd1
Name: TRAF type zinc finger domain containing 1
Synonyms: Fln29, 1110008K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231712
Homologene: 31399
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc-1alpha, PPAR Gamma Coactivator-1, Pgc-1alphaa, Pgc1, Pgco1, Gm11133, A830037N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Ddn
Name: dendrin
Synonyms: LOC328602
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13199
VEGA: 15
Homologene: 12816
Hoxb9
Name: homeobox B9
Synonyms: Hox-2.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15417
HGNC: HGNC:5120
Homologene: 7367
Bad
Name: BCL2-associated agonist of cell death
Synonyms: Bbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 12015
HGNC: HGNC:936
Homologene: 3189
Tmem252
Name: transmembrane protein 252
Synonyms: E030010A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226040
VEGA: 19
Homologene: 17717
Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Synonyms: Nmor1, Ox1, QR1, NQO1, Dia4, NAD(P)H dehydrogenase (quinone), Ox-1, NMO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18104
HGNC: HGNC:2874
Homologene: 695
Gm8989
Name: predicted gene 8989
Synonyms: Gm21911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 668128
Olfr268-ps1
Name: olfactory receptor 268, pseudogene 1
Synonyms: MOR245-17P, Gm13931, GA_x6K02T2N82Q-12713-13766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668825
Homologene: 138901
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,810,066 bp
  • T to A, chromosome 1 at 93,829,813 bp
  • T to A, chromosome 1 at 174,247,424 bp
  • C to A, chromosome 2 at 65,466,960 bp
  • T to C, chromosome 2 at 111,851,828 bp
  • G to A, chromosome 2 at 122,327,126 bp
  • T to C, chromosome 2 at 165,311,755 bp
  • G to T, chromosome 3 at 41,591,736 bp
  • T to C, chromosome 3 at 56,009,600 bp
  • T to A, chromosome 3 at 104,366,513 bp
  • A to G, chromosome 4 at 40,853,537 bp
  • A to T, chromosome 4 at 118,934,389 bp
  • T to C, chromosome 5 at 51,494,702 bp
  • C to T, chromosome 5 at 110,789,357 bp
  • T to C, chromosome 5 at 121,373,333 bp
  • T to C, chromosome 6 at 84,207,242 bp
  • A to G, chromosome 6 at 89,869,647 bp
  • C to A, chromosome 6 at 122,079,630 bp
  • A to G, chromosome 7 at 45,020,579 bp
  • T to C, chromosome 7 at 105,639,063 bp
  • C to A, chromosome 7 at 106,329,877 bp
  • C to T, chromosome 8 at 107,392,117 bp
  • C to T, chromosome 9 at 31,096,928 bp
  • C to T, chromosome 9 at 38,658,069 bp
  • T to C, chromosome 9 at 64,122,228 bp
  • G to A, chromosome 9 at 102,542,710 bp
  • G to T, chromosome 9 at 108,843,244 bp
  • A to G, chromosome 10 at 70,946,974 bp
  • G to A, chromosome 10 at 79,898,382 bp
  • T to C, chromosome 10 at 129,321,815 bp
  • T to C, chromosome 11 at 50,232,986 bp
  • T to C, chromosome 11 at 96,271,981 bp
  • C to T, chromosome 11 at 103,056,464 bp
  • A to T, chromosome 12 at 104,705,114 bp
  • T to A, chromosome 13 at 38,195,132 bp
  • C to T, chromosome 13 at 47,063,077 bp
  • T to C, chromosome 13 at 100,160,625 bp
  • G to T, chromosome 14 at 51,887,272 bp
  • T to C, chromosome 15 at 47,704,311 bp
  • TGGAG to TG, chromosome 15 at 73,783,074 bp
  • C to A, chromosome 15 at 98,805,611 bp
  • A to T, chromosome 16 at 33,727,435 bp
  • T to A, chromosome 16 at 52,047,258 bp
  • C to A, chromosome 17 at 12,612,586 bp
  • G to A, chromosome 17 at 24,158,678 bp
  • T to C, chromosome 17 at 24,504,709 bp
  • A to G, chromosome 18 at 14,633,605 bp
  • C to A, chromosome 19 at 6,950,685 bp
  • T to A, chromosome 19 at 24,677,546 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4419 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041140-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.