Strain Name:
CJ.B10ScSn-Dmdmdx/Mmjax
Stock Number:
041197-JAX
Citation ID:
RRID:MMRRC_041197-JAX
Other Names:
mdx/BALBc

Gene Information

Dmdmdx
Name: dystrophin, muscular dystrophy; X linked muscular dystrophy
Synonyms: pke, mdx, pyruvate kinase expression
Type: Allele
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Spontaneous Mutation
Dmd
Name: dystrophin, muscular dystrophy
Synonyms: Dp427, mdx, dys, Duchenne muscular dystrophy, pke, Dp71, X-linked muscular dystrophy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Spontaneous Mutation
NCBI: 13405
HGNC: HGNC:2928
Homologene: 20856
Genetic Alterations
Single-base substitution generating a premature stop codon in exon 23 of the Dmd gene.
Genotype Determination
Phenotype

Homozygous: At young adult age, the CJ.B10ScSn-Dmdmdx mice show classic dystrophic pathology and muscle force reduction as the original mdx mice. However, future studies are needed to determine whether the lifespan is altered and whether aged CJ.B10ScSn-Dmdmdx mice may show a phenotype different from that of C57BL/10ScSn-Dmdmdx/J.

Hemizygous: Not evaluated

Mammalian Phenotype Terms
Allelic Composition: Dmdmdx/Dmdmdx (Genetic Background: C57BL/10ScSn )

Allelic Composition: Dmdmdx/Dmdmdx (Genetic Background: C57BL/10ScSn-Dmdmdx/J )

Allelic Composition: Dmdmdx/Dmdmdx (Genetic Background: C57BL/10ScSnJ )

Allelic Composition: Dmdmdx/Dmdmdx (Genetic Background: involves: C57BL/10ScSn )

Allelic Composition: Dmdmdx/Dmdmdx (Genetic Background: involves: C57BL/10ScSn * CB17 )

Allelic Composition: Dmdmdx/Dmd+ (Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn )

Allelic Composition: Dmdmdx/Dmd+ (Genetic Background: involves: C57BL/10ScSn )

MeSH Terms
  • Animals
  • Crosses, Genetic
  • Female
  • Genetic Linkage
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Muscles/enzymology
  • Muscular Dystrophy, Animal/enzymology
  • Muscular Dystrophy, Animal/genetics
  • Muscular Dystrophy, Animal/pathology
  • Mutation
  • Pyruvate Kinase/genetics
  • Pyruvate Kinase/metabolism
  • X Chromosome
Strain Development

This strain was developed by crossing the C57BL/10ScSn-Dmdmdx/J mouse with the BALB/cJ mouse. At each generation, mice positive for Dmd were crossed again with BALB/cJ for greater than 7 generations.

Suggested Control Mice
Wild-type littermates
  • Cardiovascular
  • Cell Biology
  • Developmental Biology
  • Models for Human Disease
Donor
Dongsheng Duan, Ph.D., University of Missouri.
Karen J. Moore, Ph.D.
Primary Reference

Bulfield G, Siller WG, Wight PA, Moore KJ. X chromosome-linked musculardystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92.(Medline PMID: 6583703)

Colony and Husbandry Information

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org .
Coat Color
White
Eye
Pink
MMRRC Breeding System
Backcross
Breeding Scheme(s)
  • Wild-type (BALB/cJ) females x Heterozyous males or reciprocal mating
  • Wild-type (BALB/cJ) females x Homozygous males or reciprocal mating
Generation
N7+ (BALB/cJ)
Overall Breeding Performance
Excellent
NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Hetero/Hemizygotes are fertile: Yes Yes
Age Reproductive Decline: Undetermined Undetermined
Average litter size
5-9
Recommended wean age
3 weeks
Average Pups Weaned
5-9

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041197-JAX-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity2
041197-JAX-RESUS Litter recovered from cryo-archive $2,022.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.