Strain Name:
STOCK Sycp2ltm1Jw/Mmjax
Stock Number:
041440-JAX
Citation ID:
RRID:MMRRC_041440-JAX
Other Names:
Sycp2l

Gene Information

Sycp2ltm1Jw
Name: synaptonemal complex protein 2-like; targeted mutation 1, Jeremy Wang
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Knockout
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: LOC218175, EG621792, Gm40956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Knockout
NCBI: 637277
Homologene: 52882
Genetic Alterations
Sycp2l is located on Chr 13 and consists of 21 exons. In the targeted allele, deletion of exons 8-14 (encoding residues 191-383) leads to a frameshift in the transcript.
Genotype Determination
ES Cell Line
v6.5 derived from (C57BL/6 x 129S4/SvJae)F1
Phenotype

Homozygous: Progressive loss of oocytes and female fertility. Accelerated reproductive aging in females.

Heterozygous: No observed phenotype

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

MeSH Terms
  • Aging/genetics
  • Alleles
  • Animals
  • Cell Culture Techniques
  • Centromere/metabolism
  • Chromosomal Proteins, Non-Histone/deficiency
  • Chromosomal Proteins, Non-Histone/genetics
  • DNA-Binding Proteins/deficiency
  • DNA-Binding Proteins/genetics
  • Female
  • Fertility/genetics
  • Humans
  • Menopause/genetics
  • Menopause/metabolism
  • Menopause/physiology
  • Mice
  • Oocytes/metabolism
  • Ovarian Follicle/metabolism
  • Ovary/cytology
  • Ovary/metabolism
  • Ovary/physiology
  • Ovulation/physiology
  • Polymorphism, Single Nucleotide
  • Reproduction/genetics
Strain Development
A floxed PGK-neo gene was used as a drug selection marker, and TK (thymidine kinase) as a negative selection marker. Chimeras were bred with C57BL/6 mice to generate germline transmission. Heterozygous offspring were intercrossed to produce knockout mice.
Suggested Control Mice
Wild-type littermates
  • Developmental Biology
  • Models for Human Disease
  • Reproduction
Donor
P. Jeremy Wang, Ph.D., University of Pennsylvania.
Primary Reference

Zhou J, Stein P, Leu NA, Chm tal L, Xue J, Ma J, Huang X, Lampson MA, Schultz RM, Wang PJ. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. 2015 Nov 15;24(22):6505-14. Epub 2015 Sep 11. (Medline PMID: 26362258)

Colony and Husbandry Information

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org .
Coat Color
Mixed, black, or agouti
MMRRC Breeding System
Sib-mating
Breeding Scheme(s)
  • Wild-type female x Heterozygous male littermate or reciprocal mating
  • Heterozygous female x Heterozygous male littermate
  • Homozygous female x Homozygous male littermate
Overall Breeding Performance
Excellent
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Reduced Yes Reduced fertile period in homozygous females due to accelerated reproductive aging.
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: 6 to 8 months Undetermined
Average litter size
5-9
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.