Strain Name:
C57BL/6J-MtgxR4510Btlr/Mmmh
Stock Number:
041585-MU
Citation ID:
RRID:MMRRC_041585-MU
Other Names:
R4510 (G1), C57BL/6J-MtgxR4510Btlr
Major Collection:

Gene Information

Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Washc2
Name: WASH complex subunit 2`
Synonyms: Fam21, C530005J20Rik, D6Wsu116e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28006
Homologene: 41686
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242466
Homologene: 41430
Kpna6
Name: karyopherin (importin) alpha 6
Synonyms: IPOA7, importin alpha 7, NPI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, Prp8, DBF3/PRP8, D11Bwg0410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192159
Homologene: 4706
Crebrf
Name: CREB3 regulatory factor
Synonyms: A930001N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 77128
Homologene: 12672
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Atp5j
Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11957
HGNC: HGNC:847
Homologene: 1272
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, Sorla, mSorLA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Ddx17
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Synonyms: LOC381024, 2610007K22Rik, A430025E01Rik, p72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67040
VEGA: 15
HGNC: HGNC:2740
Homologene: 101101
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217351
Homologene: 23137
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Isx
Name: intestine specific homeobox
Synonyms: 9130012O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71597
Homologene: 28312
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245038
Homologene: 70580
Ackr4
Name: atypical chemokine receptor 4
Synonyms: PPR1, Ccrl1, A630091E18Rik, VSHK1, CCX-CKR, CCR11, CCBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Mmrn2
Name: multimerin 2
Synonyms: ENDOGLYX1, EndoGlyx-1, Emilin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105450
VEGA: 14
Homologene: 11697
2610507B11Rik
Name: RIKEN cDNA 2610507B11 gene
Synonyms: E1, D11Bhm178e, D11Bhm179e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72503
Homologene: 34730
Adal
Name: adenosine deaminase-like
Synonyms: 4930578F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75894
Homologene: 13827
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: 2210017P03Rik, NF-ATc, NFATc, NFAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Dhrs11
Name: dehydrogenase/reductase (SDR family) member 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192970
Homologene: 41560
Dcaf11
Name: DDB1 and CUL4 associated factor 11
Synonyms: D14Ucla1, GLO14, 0710008A13Rik, Wdr23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 28199
Homologene: 11886
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268932
VEGA: 17
Homologene: 25873
Il4ra
Name: interleukin 4 receptor, alpha
Synonyms: CD124, Il4r, IL-4 receptor alpha chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16190
HGNC: HGNC:6015
Homologene: 7784
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74338
Homologene: 52819
Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Synonyms: retinoic acid B1, CP26, P450RAI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232174
Homologene: 23179
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: 4930417M19Rik, FetA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320571
Homologene: 99882
Hpx
Name: hemopexin
Synonyms: Hpxn, hx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 212448
VEGA: 10
Homologene: 8804
Lcn2
Name: lipocalin 2
Synonyms: NRL, neu-related lipocalin, 24p3, NGAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16819
HGNC: HGNC:6526
Homologene: 4064
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 245174
HGNC: null
Homologene: 136215
BC017158
Name: cDNA sequence BC017158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233913
Homologene: 11232
Prpf18
Name: pre-mRNA processing factor 18
Synonyms: 2810441A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67229
Homologene: 2726
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: Kst1, 2010013B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233836
Homologene: 14184
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Cd26, THAM, Dpp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94253
VEGA: 13
Homologene: 9004
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 208967
Homologene: 32609
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: C030032C09Rik, Gm10937, LOC380650, AIDA-1b, E530015N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77531
Homologene: 51570
Blvra
Name: biliverdin reductase A
Synonyms: Blvr, 0610006A11Rik, 2500001N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 109778
HGNC: HGNC:1062
Homologene: 572
Mylk2
Name: myosin, light polypeptide kinase 2, skeletal muscle
Synonyms: 9830004H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228785
Homologene: 13223
Igsf1
Name: immunoglobulin superfamily, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 209268
HGNC: HGNC:5948
Homologene: 1195
Vmn2r-ps36
Name: vomeronasal 2, receptor, pseudogene 36
Synonyms: EG665442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665442
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 4,624,444 bp
  • T to C, chromosome 2 at 21,212,425 bp
  • T to C, chromosome 2 at 32,384,677 bp
  • A to G, chromosome 2 at 62,356,680 bp
  • A to T, chromosome 2 at 69,480,062 bp
  • A to T, chromosome 2 at 76,745,429 bp
  • A to G, chromosome 2 at 121,155,481 bp
  • C to A, chromosome 2 at 127,086,953 bp
  • A to C, chromosome 2 at 150,238,511 bp
  • A to G, chromosome 2 at 152,917,410 bp
  • C to A, chromosome 3 at 87,808,671 bp
  • A to G, chromosome 4 at 43,320,629 bp
  • C to T, chromosome 4 at 55,008,934 bp
  • T to C, chromosome 4 at 129,661,266 bp
  • C to T, chromosome 5 at 74,620,192 bp
  • G to A, chromosome 6 at 84,574,491 bp
  • A to T, chromosome 6 at 116,220,556 bp
  • A to G, chromosome 7 at 7,418,222 bp
  • G to T, chromosome 7 at 30,724,253 bp
  • A to G, chromosome 7 at 105,592,088 bp
  • A to T, chromosome 7 at 123,235,635 bp
  • A to G, chromosome 7 at 125,576,108 bp
  • A to T, chromosome 7 at 128,276,140 bp
  • G to A, chromosome 8 at 74,873,670 bp
  • C to T, chromosome 9 at 41,977,572 bp
  • T to C, chromosome 9 at 104,098,731 bp
  • C to A, chromosome 9 at 111,467,992 bp
  • T to A, chromosome 10 at 29,224,823 bp
  • A to G, chromosome 10 at 90,510,790 bp
  • T to C, chromosome 11 at 75,491,826 bp
  • T to C, chromosome 11 at 78,277,328 bp
  • T to C, chromosome 11 at 84,825,516 bp
  • A to T, chromosome 11 at 117,742,958 bp
  • A to C, chromosome 13 at 14,357,191 bp
  • A to C, chromosome 13 at 73,683,975 bp
  • T to C, chromosome 14 at 34,403,059 bp
  • T to A, chromosome 14 at 55,563,038 bp
  • A to T, chromosome 15 at 79,538,592 bp
  • G to A, chromosome 16 at 37,048,563 bp
  • T to C, chromosome 16 at 84,827,974 bp
  • G to A, chromosome 17 at 24,506,628 bp
  • A to G, chromosome 17 at 26,742,964 bp
  • A to G, chromosome 18 at 6,214,011 bp
  • A to G, chromosome 18 at 80,635,579 bp
  • A to G, chromosome X at 49,786,173 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4510 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041585-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.