Strain Name:
C57BL/6J-MtgxR4515Btlr/Mmmh
Stock Number:
041589-MU
Citation ID:
RRID:MMRRC_041589-MU
Other Names:
R4515 (G1), C57BL/6J-MtgxR4515Btlr
Major Collection:

Gene Information

Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: Gabt2, BGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14411
Homologene: 128225
Ckm
Name: creatine kinase, muscle
Synonyms: MCK, M-CK, Ckmm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12715
HGNC: HGNC:1994
Homologene: 20432
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Eh domain, SH3 domain regulator of endocytosis 1, Sh3p17, Intersectin-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: 2310014L03Rik, Centerin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71907
Homologene: 23633
Txn2
Name: thioredoxin 2
Synonyms: 2510006J11Rik, Trx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56551
Homologene: 40849
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Orc4
Name: origin recognition complex, subunit 4
Synonyms: mMmORC4, Orc4, Orc4l, Orc4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Kif5b
Name: kinesin family member 5B
Synonyms: kinesin heavy chain, Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Glod4
Name: glyoxalase domain containing 4
Synonyms: 2700085E05Rik, 1700082G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67201
Homologene: 9376
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, 2610207I05Rik, C130002K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: Nraps, Raps, rapsyn, 43kDa acetylcholine receptor-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Pdik1l
Name: PDLIM1 interacting kinase 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230809
Homologene: 36977
Foxi1
Name: forkhead box I1
Synonyms: HFH-3, Fkh10, Hfh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14233
HGNC: HGNC:3815
Homologene: 8140
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: JPDI, D2Ertd706e, ERdj5, 1200006L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66861
Homologene: 10358
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Stk11
Name: serine/threonine kinase 11
Synonyms: Par-4, Lkb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20869
Homologene: 393
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Wsu16e, Copg, D6Ertd71e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Sec31a
Name: Sec31 homolog A (S. cerevisiae)
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69162
Homologene: 42056
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: GIV, A430106J12Rik, C330012F17Rik, HkRP1, Girdin, D130005J21Rik, C130096N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: tailless, Tlx, Mtll, Nr2e1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Gm9008
Name: predicted pseudogene 9008
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 668155
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnhd3, 2900022L05Rik, D330014H01Rik, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Prp7, Mi-2 alpha, Prp9-1, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Oc90
Name: otoconin 90
Synonyms: PLA2L, Pla2ll, Ocn-95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18256
HGNC: HGNC:8100
Homologene: 19021
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16578
Homologene: 65620
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637896
Homologene: 115466
Olfr954
Name: olfactory receptor 954
Synonyms: MOR171-42, GA_x6K02T2PVTD-33158015-33158950, MOR171-53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258328
VEGA: 9
Homologene: 71961
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224572
Homologene: 115024
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Prkch
Name: protein kinase C, eta
Synonyms: Pkch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18755
HGNC: HGNC:9403
Homologene: 84384
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: A130097D21Rik, Prss7, enterokinase, enteropeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243308
Homologene: 65621
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: SAPLT, 1700042F02Rik, 1700056N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67331
VEGA: 10
Homologene: 19034
Ptger4
Name: prostaglandin E receptor 4 (subtype EP4)
Synonyms: EP4, Ptgerep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19219
HGNC: HGNC:9596
Homologene: 20261
Rabac1
Name: Rab acceptor 1 (prenylated)
Synonyms: Gbpap1, 2310040I06Rik, PRA1, prenylin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14470
HGNC: HGNC:9794
Homologene: 38182
Olfr834
Name: olfactory receptor 834
Synonyms: MOR153-4_p, GA_x6K02T2PVTD-12724921-12725859, MOR153-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258074
HGNC: HGNC:8467
Homologene: 128143
Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Synonyms: PAI1, PAI-1, Planh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18787
HGNC: HGNC:8583
Homologene: 68070
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394430
Homologene: 133281
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Tmem38a
Name: transmembrane protein 38A
Synonyms: TRIC-A, 1110001E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74166
Homologene: 11449
Nkx3-2
Name: NK3 homeobox 2
Synonyms: Bapx1, Nkx-3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12020
HGNC: HGNC:951
Homologene: 68168
H2-M10.3
Name: histocompatibility 2, M region locus 10.3
Synonyms: 5.3H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110696
Homologene: 117973
Hemgn
Name: hemogen
Synonyms: 4921524M03Rik, EDAG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 93966
Homologene: 14223
Alg6
Name: asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
Synonyms: E230028F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320438
Homologene: 6920
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas1, Acs1, ACAS, AceCS1, Acas2, acetyl-CoA synthetase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60525
Homologene: 6469
Tmprss11a
Name: transmembrane protease, serine 11a
Synonyms: LOC194597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 194597
Homologene: 62723
Paqr3
Name: progestin and adipoQ receptor family member III
Synonyms: 6330415A20Rik, RKTG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231474
Homologene: 71077
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Lce1l
Name: late cornified envelope 1L
Synonyms: 1110008K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73730
Fam122c
Name: family with sequence similarity 122, member C
Synonyms: 4930432H15Rik, 4930527G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73866
Homologene: 87062
Gm9372
Name: predicted gene 9372
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 668809
Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Gm20661
Name: predicted gene 20661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm12192
Name: predicted gene 12192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100416544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 88,056,197 bp
  • G to A, chromosome 2 at 48,937,489 bp
  • C to A, chromosome 2 at 66,093,610 bp
  • G to T, chromosome 2 at 80,317,524 bp
  • G to A, chromosome 2 at 91,043,212 bp
  • C to A, chromosome 2 at 155,556,363 bp
  • T to C, chromosome 3 at 92,850,474 bp
  • G to A, chromosome 3 at 124,292,096 bp
  • T to C, chromosome 4 at 46,396,477 bp
  • A to T, chromosome 4 at 99,752,786 bp
  • T to C, chromosome 4 at 123,493,988 bp
  • T to C, chromosome 4 at 134,278,896 bp
  • T to C, chromosome 4 at 156,225,531 bp
  • C to T, chromosome 5 at 41,763,938 bp
  • C to T, chromosome 5 at 86,420,196 bp
  • T to A, chromosome 5 at 97,103,361 bp
  • A to G, chromosome 5 at 100,365,958 bp
  • G to A, chromosome 5 at 137,069,468 bp
  • G to T, chromosome 5 at 138,647,744 bp
  • A to G, chromosome 6 at 42,589,996 bp
  • C to T, chromosome 6 at 76,496,809 bp
  • A to G, chromosome 6 at 87,907,546 bp
  • T to A, chromosome 6 at 121,353,530 bp
  • A to G, chromosome 7 at 19,420,284 bp
  • A to T, chromosome 7 at 24,970,160 bp
  • A to T, chromosome 7 at 86,954,258 bp
  • T to C, chromosome 7 at 118,210,742 bp
  • T to C, chromosome 8 at 27,385,090 bp
  • C to T, chromosome 8 at 72,572,161 bp
  • T to A, chromosome 8 at 93,020,904 bp
  • T to C, chromosome 8 at 125,492,226 bp
  • T to G, chromosome 9 at 18,987,982 bp
  • C to T, chromosome 9 at 39,462,231 bp
  • A to G, chromosome 9 at 105,672,725 bp
  • G to A, chromosome 9 at 107,992,951 bp
  • G to T, chromosome 9 at 108,104,078 bp
  • A to G, chromosome 9 at 110,489,867 bp
  • T to A, chromosome 9 at 118,559,008 bp
  • G to A, chromosome 10 at 42,578,191 bp
  • A to G, chromosome 10 at 80,116,601 bp
  • C to T, chromosome 10 at 80,523,847 bp
  • T to C, chromosome 11 at 29,482,651 bp
  • A to G, chromosome 11 at 34,207,972 bp
  • C to T, chromosome 11 at 49,702,536 bp
  • G to T, chromosome 11 at 69,349,877 bp
  • A to G, chromosome 11 at 69,465,631 bp
  • T to A, chromosome 11 at 76,243,571 bp
  • A to G, chromosome 11 at 87,568,057 bp
  • A to G, chromosome 12 at 73,702,838 bp
  • T to A, chromosome 12 at 104,001,294 bp
  • A to T, chromosome 13 at 55,476,229 bp
  • C to A, chromosome 15 at 5,242,379 bp
  • A to G, chromosome 15 at 65,892,393 bp
  • A to T, chromosome 15 at 77,915,443 bp
  • C to T, chromosome 16 at 78,957,356 bp
  • G to A, chromosome 16 at 91,899,649 bp
  • A to G, chromosome 17 at 19,681,213 bp
  • C to T, chromosome 17 at 36,367,830 bp
  • A to G, chromosome 18 at 6,208,257 bp
  • C to A, chromosome 18 at 20,601,387 bp
  • T to A, chromosome 18 at 37,091,379 bp
  • A to G, chromosome 18 at 61,987,693 bp
  • G to A, chromosome X at 53,293,499 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4515 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041589-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.