Strain Name:
C57BL/6J-MtgxR3876Btlr/Mmmh
Stock Number:
041606-MU
Citation ID:
RRID:MMRRC_041606-MU
Other Names:
R3876 (G1), C57BL/6J-MtgxR3876Btlr
Major Collection:

Strain Information

Chrnb4
Name: cholinergic receptor, nicotinic, beta polypeptide 4
Synonyms: Acrb-4, Acrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108015
VEGA: 9
HGNC: HGNC:1964
Homologene: 20196
Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: paladin, X99384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, p55alpha, PI3K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Septin3
Name: septin 3
Synonyms: Sep3, B530002E20Rik, 3110018K01Rik, Sept3, Gm46500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 24050
VEGA: 15
Homologene: 99740
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: RPC2, 2700078H01Rik, A330032P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, NEP, neutral endopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, PM-Scl, RRP6, p4, p3, p2, Pmscl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Ncstn
Name: nicastrin
Synonyms: nicastrin, 9430068N19Rik, Nct, D1Dau13e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59287
Homologene: 41029
Ibtk
Name: inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms: 5430411K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108837
Homologene: 34661
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: BACH1, 8030460J03Rik, 3110009N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237911
Homologene: 32766
Sfrp2
Name: secreted frizzled-related protein 2
Synonyms: Sdf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20319
Homologene: 56438
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18b, Munc-18-2, C79054, Sxtp2, Munc18b, muSec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20911
Homologene: 55530
Prl8a6
Name: prolactin family 8, subfamily a, member 6
Synonyms: Prlpc, PLP-Ca, PLP-calpha, Prlpc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19112
HGNC: HGNC:9445
Eogt
Name: EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101351
Homologene: 65276
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Krt34
Name: keratin 34
Synonyms: 4733401E01Rik, Krt1-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16672
HGNC: HGNC:6452
Homologene: 31083
Or6c210
Name: olfactory receptor family 6 subfamily C member 210
Synonyms: GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258541
Homologene: 27203
4930458L03Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Gata3
Name: GATA binding protein 3
Synonyms: Gata-3, jal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Or4k39
Name: olfactory receptor family 4 subfamily K member 39, pseudogene 1
Synonyms: GA_x6K02T2Q125-72459956-72460837, MOR248-17P, MOR248-25_p, Olfr1285
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545447
Lipn
Name: lipase, family member N
Synonyms: 2210418G03Rik, Lipl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70166
Homologene: 66969
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666060
Homologene: 8939
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239081
Homologene: 77905
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269109
Homologene: 41400
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Or4c29
Name: olfactory receptor family 4 subfamily C member 29
Synonyms: GA_x6K02T2Q125-50386882-50385950, MOR230-7, Olfr1209
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258453
Homologene: 128155
Fbxo43
Name: F-box protein 43
Synonyms: 4930533G20Rik, XErp1 homolog, endogenous meiotic inhibitor 2, Emi2, early mitotic inhibitor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78803
VEGA: 15
Homologene: 66393
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, R21, Oprk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240843
Homologene: 10905
Entpd1
Name: ectonucleoside triphosphate diphosphohydrolase 1
Synonyms: NTPDase-1, Cd39, ectoapyrase, 2610206B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12495
HGNC: HGNC:3363
Homologene: 20423
Zfp512b
Name: zinc finger protein 512B
Synonyms: LOC269401, Znf512b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269401
Homologene: 69314
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 3110012E06Rik, 4930438C08Rik, 4930589M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75906
Homologene: 11600
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 252875
Homologene: 10371
4931414P19Rik
Name: RIKEN cDNA 4931414P19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74359
VEGA: 14
Homologene: 11078
Or10d1c
Name: olfactory receptor family 10 subfamily D member 1C
Synonyms: GA_x6K02T2PVTD-32678895-32677963, MOR224-6, Olfr934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258434
VEGA: 9
Homologene: 51730
Or6z7
Name: olfactory receptor family 6 subfamily Z member 7
Synonyms: MOR103-8, GA_x6K02T2QGBW-3210997-3210059, Olfr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18349
Homologene: 72037
Timd2
Name: T cell immunoglobulin and mucin domain containing 2
Synonyms: Tim2, TIM-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171284
Homologene: 82236
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Rgs13
Name: regulator of G-protein signaling 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246709
HGNC: HGNC:9995
Homologene: 14774
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 5,602,661 bp
  • T to A, chromosome 1 at 123,353,487 bp
  • T to A, chromosome 1 at 144,140,790 bp
  • C to A, chromosome 1 at 158,246,846 bp
  • A to G, chromosome 1 at 172,070,073 bp
  • A to T, chromosome 2 at 9,863,143 bp
  • A to G, chromosome 2 at 41,445,194 bp
  • T to C, chromosome 2 at 88,909,608 bp
  • T to C, chromosome 2 at 111,408,622 bp
  • AG to AGG, chromosome 2 at 181,588,763 bp
  • A to T, chromosome 3 at 63,362,059 bp
  • C to T, chromosome 3 at 83,767,028 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • T to G, chromosome 4 at 45,284,093 bp
  • ATGTG to ATG, chromosome 4 at 70,289,977 bp
  • T to A, chromosome 4 at 148,572,919 bp
  • G to T, chromosome 5 at 5,584,645 bp
  • G to A, chromosome 6 at 8,233,189 bp
  • G to A, chromosome 6 at 97,120,190 bp
  • G to A, chromosome 7 at 6,481,132 bp
  • T to C, chromosome 8 at 3,633,369 bp
  • C to T, chromosome 8 at 125,888,158 bp
  • T to A, chromosome 9 at 38,982,870 bp
  • T to C, chromosome 9 at 55,043,898 bp
  • A to G, chromosome 9 at 85,718,426 bp
  • A to T, chromosome 10 at 5,052,345 bp
  • C to T, chromosome 10 at 53,699,061 bp
  • T to A, chromosome 10 at 61,347,487 bp
  • T to C, chromosome 10 at 78,220,186 bp
  • G to A, chromosome 10 at 84,720,518 bp
  • C to T, chromosome 10 at 129,660,274 bp
  • T to C, chromosome 11 at 30,856,068 bp
  • T to C, chromosome 11 at 46,671,020 bp
  • T to C, chromosome 11 at 60,719,872 bp
  • T to C, chromosome 11 at 86,152,790 bp
  • T to C, chromosome 11 at 100,040,965 bp
  • T to A, chromosome 11 at 110,288,051 bp
  • A to G, chromosome 12 at 51,768,730 bp
  • A to G, chromosome 12 at 58,268,644 bp
  • G to A, chromosome 12 at 70,201,339 bp
  • T to A, chromosome 13 at 11,588,159 bp
  • A to T, chromosome 13 at 27,433,032 bp
  • A to G, chromosome 13 at 64,920,931 bp
  • G to A, chromosome 13 at 101,684,957 bp
  • G to A, chromosome 14 at 50,363,154 bp
  • G to A, chromosome 14 at 54,591,400 bp
  • A to G, chromosome 15 at 36,152,112 bp
  • A to T, chromosome 15 at 82,285,801 bp
  • A to G, chromosome 16 at 22,806,512 bp
  • G to T, chromosome 19 at 34,069,428 bp
  • T to C, chromosome 19 at 40,736,820 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3876 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041606-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.