Strain Name:
C57BL/6J-MtgxR4115Btlr/Mmmh
Stock Number:
041630-MU
Citation ID:
RRID:MMRRC_041630-MU
Other Names:
R4115 (G1), C57BL/6J-MtgxR4115Btlr
Major Collection:

Gene Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, nmf261, neuroaxonal dystrophy, Spnb4, 5830426A08Rik, ROSA62, 1700022P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 80297
Homologene: 11879
Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C130076O07Rik, C030017F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Nagk
Name: N-acetylglucosamine kinase
Synonyms: GlcNAc kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56174
Homologene: 9720
Gnl3
Name: guanine nucleotide binding protein-like 3 (nucleolar)
Synonyms: nucleostemin, NS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30877
VEGA: 14
Homologene: 56670
Nfkbil1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
Synonyms: Def-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18038
HGNC: HGNC:7800
Homologene: 3671
Morc3
Name: microrchidia 3
Synonyms: 1110051N18Rik, Zcwcc3, 1110051N18Rik, D16Jhu32e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 338467
Homologene: 32257
Reps1
Name: RalBP1 associated Eps domain containing protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19707
Homologene: 7515
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20873
Homologene: 7962
Dcun1d3
Name: DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Synonyms: 1700020A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233805
Homologene: 16155
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 207304
VEGA: 12
Homologene: 9115
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Mc4r
Name: melanocortin 4 receptor
Synonyms: Pkcp, Fatboy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17202
VEGA: 18
HGNC: HGNC:6932
Homologene: 4320
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
LTO1
Name: ABCE maturation factor
Synonyms: Oraov1, TAOS1, 2210010N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72284
Homologene: 12457
Aplp2
Name: amyloid beta (A4) precursor-like protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11804
VEGA: 9
HGNC: HGNC:598
Homologene: 20396
Nudcd2
Name: NudC domain containing 2
Synonyms: D11Ertd603e, 2700047N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 52653
Homologene: 12094
Atrip
Name: ATR interacting protein
Synonyms: 6620401K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235610
Homologene: 15601
Sec22a
Name: SEC22 homolog A, vesicle trafficking protein
Synonyms: Sec22l2, 1810005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 317717
Homologene: 8246
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Cd202b, Hyk, Tie2, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21687
Homologene: 397
Ism2
Name: isthmin 2
Synonyms: LOC217738, Thsd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217738
Homologene: 83509
Mycbpap
Name: MYCBP associated protein
Synonyms: 4932408B01Rik, AMAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104601
Homologene: 49982
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216874
Homologene: 9021
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Itpr5, Ip3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225997
VEGA: 19
Homologene: 9767
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, Spna-1, ihj, erythroid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20739
Homologene: 74460
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5A, b2b585Clo, SPC6, PC5/6A, b2b1549Clo, PC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 69888
HGNC: HGNC:2623
Homologene: 133566
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: 2600010P09Rik, Mi-2 alpha, Prp9-1, Chd7, Prp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: LOC330998, B230218L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330998
Homologene: 19814
Kif1a
Name: kinesin family member 1A
Synonyms: LOC381283, N-3 kinesin, Kns1, C630002N23Rik, ATSV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270035
Homologene: 56358
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Synonyms: 1300012D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71773
Homologene: 68144
Psg20
Name: pregnancy-specific glycoprotein 20
Synonyms: EG434540, cea7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434540
Homologene: 110989
Gm13083
Name: predicted gene 13083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 279185
Homologene: 133722
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219140
Homologene: 19482
Cfhr3
Name: complement factor H-related 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 624286
Homologene: 138664
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100042165
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm2, Pgm-2, Pgm1a, 2610020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627367
Homologene: 115024
Olfr341
Name: olfactory receptor 341
Synonyms: MOR136-2, GA_x6K02T2NLDC-33174915-33173974
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258952
Homologene: 74160
BC035044
Name: cDNA sequence BC035044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232406
4933413J09Rik
Name: RIKEN cDNA 4933413J09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71106
Tssk3
Name: testis-specific serine kinase 3
Synonyms: Tssk-3, 4930594I21Rik, Stk22d, Stk22c, 1700014N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 58864
Homologene: 62163
Gm6625
Name: predicted gene 6625
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 625801
Ighv11-1
Name: immunoglobulin heavy variable 11-1
Synonyms: Gm16611
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 780804
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 93,052,538 bp
  • G to A, chromosome 1 at 110,138,309 bp
  • T to C, chromosome 1 at 139,622,191 bp
  • T to C, chromosome 1 at 174,240,357 bp
  • A to T, chromosome 2 at 36,479,785 bp
  • A to G, chromosome 2 at 71,441,222 bp
  • T to C, chromosome 3 at 40,805,177 bp
  • T to C, chromosome 4 at 94,849,683 bp
  • C to T, chromosome 4 at 99,962,151 bp
  • T to C, chromosome 4 at 129,489,507 bp
  • A to G, chromosome 4 at 143,617,456 bp
  • A to G, chromosome 5 at 86,926,414 bp
  • T to C, chromosome 5 at 104,519,433 bp
  • G to A, chromosome 6 at 83,795,304 bp
  • C to T, chromosome 6 at 128,890,850 bp
  • C to T, chromosome 6 at 146,425,510 bp
  • A to G, chromosome 7 at 18,685,980 bp
  • C to T, chromosome 7 at 27,391,570 bp
  • T to A, chromosome 7 at 81,282,807 bp
  • T to C, chromosome 7 at 114,521,727 bp
  • T to C, chromosome 7 at 119,859,734 bp
  • G to A, chromosome 7 at 144,919,646 bp
  • T to A, chromosome 8 at 25,580,327 bp
  • T to G, chromosome 8 at 89,147,109 bp
  • C to T, chromosome 9 at 31,157,826 bp
  • A to T, chromosome 9 at 54,446,988 bp
  • T to A, chromosome 9 at 56,898,394 bp
  • A to G, chromosome 9 at 89,729,874 bp
  • A to T, chromosome 9 at 109,074,054 bp
  • C to T, chromosome 10 at 18,104,207 bp
  • T to C, chromosome 11 at 40,736,607 bp
  • T to G, chromosome 11 at 69,357,517 bp
  • T to C, chromosome 11 at 70,676,474 bp
  • C to A, chromosome 11 at 94,512,225 bp
  • T to C, chromosome 12 at 44,566,326 bp
  • A to T, chromosome 12 at 51,768,723 bp
  • A to G, chromosome 12 at 87,287,031 bp
  • A to G, chromosome 12 at 113,982,065 bp
  • C to A, chromosome 14 at 26,376,391 bp
  • T to G, chromosome 14 at 31,016,856 bp
  • G to T, chromosome 14 at 60,692,478 bp
  • A to G, chromosome 16 at 35,318,832 bp
  • G to A, chromosome 16 at 93,873,339 bp
  • T to C, chromosome 17 at 18,928,070 bp
  • C to A, chromosome 17 at 32,158,433 bp
  • A to G, chromosome 17 at 35,221,310 bp
  • T to A, chromosome 18 at 66,859,979 bp
  • C to T, chromosome 19 at 17,433,419 bp
  • T to C, chromosome 19 at 18,832,557 bp
  • A to G, chromosome 19 at 39,176,559 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4115 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041630-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.