Strain Name:
C57BL/6J-MtgxR4128Btlr/Mmmh
Stock Number:
041635-MU
Citation ID:
RRID:MMRRC_041635-MU
Other Names:
R4128 (G1), C57BL/6J-MtgxR4128Btlr
Major Collection:

Gene Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Jarid2
Name: jumonji, AT rich interactive domain 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Cdk19
Name: cyclin-dependent kinase 19
Synonyms: 2700084L06Rik, Cdc2l6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78334
VEGA: 10
Homologene: 22862
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Ireb2
Name: iron responsive element binding protein 2
Synonyms: Irp2, D9Ertd85e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, 2610511G22Rik, 6030460N08Rik, TRIP230, GMAP-210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 109181
Homologene: 20897
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20912
Homologene: 5260
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: PILSAP, ERAAP, Arts1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 360216
Homologene: 9728
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: retSDR3, 0610039E24Rik, Dhrs10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66065
Homologene: 133800
Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Synonyms: Kir6.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16514
HGNC: HGNC:6257
Homologene: 441
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27028
Homologene: 22782
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 272158
Homologene: 131253
Bbox1
Name: butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170442
HGNC: HGNC:964
Homologene: 2967
Lyplal1
Name: lysophospholipase-like 1
Synonyms: Q96AVO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226791
Homologene: 13683
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229595
Homologene: 23141
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67608
Homologene: 57048
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: C230094F14Rik, Rab39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270160
Homologene: 56773
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20840
Homologene: 2371
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Myrip
Name: myosin VIIA and Rab interacting protein
Synonyms: Slac2-c, A230081N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245049
Homologene: 9150
Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Synonyms: Gnas1, Gs-alpha, Gs alpha, G alpha s, Nesp55, P2, P3, P1, Gsa, neuroendocrine-specific Golgi protein p55 isoform 1, XLalphas, Nesp, Gnasxl, Nespl, Oedsml, Galphas, SCG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Olfr509
Name: olfactory receptor 509
Synonyms: GA_x6K02T2PBJ9-10976304-10975339, MOR267-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258369
Homologene: 131128
Olfr761
Name: olfactory receptor 761
Synonyms: GA_x6K02T2PSCP-2403971-2403000, MOR218-6P, MOR218-5P, MOR218-12, MOR218-6P, Olfr1552-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258094
Homologene: 134080
Ubash3a
Name: ubiquitin associated and SH3 domain containing, A
Synonyms: 5830413C03Rik, Sts-2, TULA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328795
Homologene: 56833
Tmem179
Name: transmembrane protein 179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104885
VEGA: 12
Homologene: 16809
Cavin2
Name: caveolae associated 2
Synonyms: cavin 2, Sdpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20324
Homologene: 3422
Csl
Name: citrate synthase like
Synonyms: 1700007H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71832
VEGA: 10
Homologene: 7131
Ighj4
Name: immunoglobulin heavy joining 4
Synonyms: Gm16734
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 777656
Rnf187
Name: ring finger protein 187
Synonyms: 2410016F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108660
Homologene: 23360
Gm5071
Name: predicted pseudogene 5071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278087
Homologene: 136060
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 51,301,422 bp
  • A to G, chromosome 1 at 97,834,468 bp
  • A to G, chromosome 1 at 186,089,539 bp
  • C to A, chromosome 2 at 52,292,700 bp
  • A to G, chromosome 2 at 110,270,180 bp
  • C to T, chromosome 2 at 128,777,438 bp
  • A to G, chromosome 2 at 132,297,271 bp
  • A to G, chromosome 2 at 174,300,165 bp
  • C to T, chromosome 3 at 95,681,672 bp
  • T to C, chromosome 3 at 108,794,831 bp
  • T to C, chromosome 4 at 119,187,111 bp
  • A to G, chromosome 5 at 34,103,951 bp
  • G to T, chromosome 6 at 54,272,978 bp
  • G to A, chromosome 7 at 45,563,008 bp
  • A to G, chromosome 7 at 46,099,719 bp
  • T to C, chromosome 7 at 108,646,426 bp
  • C to A, chromosome 7 at 132,966,552 bp
  • T to A, chromosome 9 at 53,686,504 bp
  • T to A, chromosome 9 at 54,881,432 bp
  • C to A, chromosome 9 at 73,734,537 bp
  • C to A, chromosome 9 at 111,604,058 bp
  • C to A, chromosome 9 at 120,464,698 bp
  • A to G, chromosome 10 at 40,394,395 bp
  • T to C, chromosome 10 at 99,758,600 bp
  • A to T, chromosome 11 at 58,934,057 bp
  • G to A, chromosome 11 at 121,250,435 bp
  • G to A, chromosome 12 at 101,895,698 bp
  • A to T, chromosome 12 at 112,511,027 bp
  • T to C, chromosome 12 at 113,428,556 bp
  • T to C, chromosome 13 at 13,476,372 bp
  • T to C, chromosome 13 at 44,902,256 bp
  • T to C, chromosome 13 at 74,666,196 bp
  • C to T, chromosome 16 at 22,078,621 bp
  • T to C, chromosome 17 at 31,237,275 bp
  • A to G, chromosome 17 at 37,952,790 bp
  • A to T, chromosome X at 91,932,262 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4128 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041635-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.