Strain Name:
C57BL/6J-MtgxR4130Btlr/Mmmh
Stock Number:
041636-MU
Citation ID:
RRID:MMRRC_041636-MU
Other Names:
R4130 (G1), C57BL/6J-MtgxR4130Btlr
Major Collection:

Gene Information

Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70508
Homologene: 10634
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98732
Homologene: 40842
Nup35
Name: nucleoporin 35
Synonyms: 5330402E05Rik, 2310006I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69482
Homologene: 44517
Wdr5
Name: WD repeat domain 5
Synonyms: Big-3, 2410008O07Rik, Bmp2-induced gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140858
Homologene: 59931
Bcar1
Name: breast cancer anti-estrogen resistance 1
Synonyms: p130Cas, Cas, Crkas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12927
HGNC: HGNC:971
Homologene: 7674
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Cytl1
Name: cytokine-like 1
Synonyms: C17, 4930443F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231162
Homologene: 10254
Golga2
Name: golgi autoantigen, golgin subfamily a, 2
Synonyms: GM130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99412
HGNC: HGNC:4425
Homologene: 3300
F10
Name: coagulation factor X
Synonyms: fX, Cf10, AI194738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14058
HGNC: HGNC:3528
Homologene: 30976
Eif4e1b
Name: eukaryotic translation initiation factor 4E family member 1B
Synonyms: Eif4eloo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218268
Homologene: 100945
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Olfr702
Name: olfactory receptor 702
Synonyms: GA_x6K02T2PBJ9-9202245-9201289, MOR260-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258590
Homologene: 121512
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, 4930544G21Rik, SKIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77629
Homologene: 18172
Ankrd29
Name: ankyrin repeat domain 29
Synonyms: G630054C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225187
Homologene: 17839
Skap1
Name: src family associated phosphoprotein 1
Synonyms: Skap-55, 1700091G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78473
Homologene: 2764
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97187
Homologene: 103830
Pdzd9
Name: PDZ domain containing 9
Synonyms: 4930408O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67983
Homologene: 27865
1700021A07Rik
Name: RIKEN cDNA 1700021A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Tedc1
Name: tubulin epsilon and delta complex 1
Synonyms: 4930427A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104732
Homologene: 77129
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434113
Homologene: 113703
A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
Synonyms: LOC333424, alpha4GnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333424
Homologene: 87446
RP23-453G13.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm16537
Name: predicted gene 16537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102638434
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 83,277,898 bp
  • T to G, chromosome 1 at 180,509,078 bp
  • A to G, chromosome 1 at 185,204,297 bp
  • G to T, chromosome 2 at 27,520,429 bp
  • G to A, chromosome 2 at 32,288,166 bp
  • G to A, chromosome 2 at 80,656,099 bp
  • T to A, chromosome 4 at 144,208,809 bp
  • T to C, chromosome 5 at 37,735,641 bp
  • T to A, chromosome 7 at 8,367,919 bp
  • C to T, chromosome 7 at 106,823,585 bp
  • A to T, chromosome 7 at 120,662,869 bp
  • C to T, chromosome 7 at 133,912,924 bp
  • A to G, chromosome 8 at 13,055,584 bp
  • A to G, chromosome 8 at 111,714,165 bp
  • A to G, chromosome 9 at 99,620,618 bp
  • T to A, chromosome 9 at 112,155,308 bp
  • T to C, chromosome 10 at 21,425,542 bp
  • A to G, chromosome 11 at 96,526,045 bp
  • T to C, chromosome 11 at 119,483,006 bp
  • T to A, chromosome 12 at 113,163,208 bp
  • C to T, chromosome 13 at 54,787,317 bp
  • T to C, chromosome 13 at 99,431,680 bp
  • G to A, chromosome 15 at 91,755,794 bp
  • A to T, chromosome 15 at 99,719,277 bp
  • T to C, chromosome 16 at 50,224,858 bp
  • G to A, chromosome 18 at 12,254,700 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4130 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041636-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.