Strain Name:
C57BL/6J-MtgxR4273Btlr/Mmmh
Stock Number:
041645-MU
Citation ID:
RRID:MMRRC_041645-MU
Other Names:
R4273 (G1), C57BL/6J-MtgxR4273Btlr
Major Collection:

Gene Information

Sox9
Name: SRY (sex determining region Y)-box 9
Synonyms: 2010306G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20682
Homologene: 294
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Psmb2
Name: proteasome (prosome, macropain) subunit, beta type 2
Synonyms: HC7-I, D4Wsu33e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26445
HGNC: HGNC:9539
Homologene: 2088
Brd4
Name: bromodomain containing 4
Synonyms: MCAP, HUNK1, WI-11513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57261
Homologene: 136213
Appbp2
Name: amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Synonyms: PAT1, 1300003O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66884
HGNC: HGNC:622
Homologene: 31378
Exoc5
Name: exocyst complex component 5
Synonyms: PRO1912, SEC10, Sec10l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105504
Homologene: 38195
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: SPCA, ATP2C1A, PMR1, 1700121J11Rik, D930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235574
Homologene: 56672
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212285
Homologene: 9064
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 5830411K19Rik, 4933425I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71148
Homologene: 136176
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Zmynd11
Name: zinc finger, MYND domain containing 11
Synonyms: 2210402G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66505
Homologene: 4828
Riok3
Name: RIO kinase 3
Synonyms: 1200013N13Rik, Sudd, D18Ertd331e, E130306C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66878
VEGA: 18
Homologene: 2843
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Nepro
Name: nucleolus and neural progenitor protein
Synonyms: BC027231
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212547
Homologene: 9127
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18291
Homologene: 51066
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21687
Homologene: 397
Fcer2a
Name: Fc receptor, IgE, low affinity II, alpha polypeptide
Synonyms: low-affinity IgE receptor, FC epsilon RII, Fce2, Ly-42, CD23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14128
HGNC: HGNC:3612
Homologene: 1517
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75288
Homologene: 45939
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277978
Homologene: 18629
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Ngrn
Name: neugrin, neurite outgrowth associated
Synonyms: neurite outgrowth associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83485
Homologene: 32330
A530053G22Rik
Name: RIKEN cDNA A530053G22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 208079
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Kv1.2, Kca1-2, Mk-2, Akr6a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218989
Homologene: 49506
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Tsks
Name: testis-specific serine kinase substrate
Synonyms: clone 4, Tssks1, Tsks, Stk22s1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22116
Homologene: 7984
Mvp
Name: major vault protein
Synonyms: VAULT1, LRP, 2310009M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78388
HGNC: HGNC:7531
Homologene: 3752
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80902
Homologene: 68317
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327963
Homologene: 88945
Pramel24
Name: PRAME like 24
Synonyms: Gm13078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277666
Homologene: 133722
Slc52a3
Name: solute carrier protein family 52, member 3
Synonyms: 2310046K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69698
Homologene: 12324
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381067
Homologene: 136287
Lims2
Name: LIM and senescent cell antigen like domains 2
Synonyms: PINCH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225341
VEGA: 18
Homologene: 41214
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, Zfp-52, KRAB11, Zfp76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12549
Homologene: 10644
Itm2c
Name: integral membrane protein 2C
Synonyms: BRI3, 3110038L02Rik, ITM3, Bricd2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64294
HGNC: HGNC:6175
Homologene: 11186
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, 4933400N19Rik, Gasz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384221
Homologene: 104825
Zfp119b
Name: zinc finger protein 119b
Synonyms: BC031441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240120
Fam98b
Name: family with sequence similarity 98, member B
Synonyms: 2610510H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68215
Homologene: 72241
Dlgap1
Name: DLG associated protein 1
Synonyms: SAPAP1, DAP-1 beta, D17Bwg0511e, GKAP/SAPAP, Sapap1, 4933422O14Rik, Gkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: PGR20, Gpr111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 435529
Homologene: 45213
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Acer2
Name: alkaline ceramidase 2
Synonyms: 2410116I05Rik, Asah3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230379
Homologene: 14986
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233222
Homologene: 131159
Olfr129
Name: olfactory receptor 129
Synonyms: MOR263-9, GA_x6K02T2PSCP-2503741-2502776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258324
Homologene: 133641
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50524
Homologene: 9269
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113864
Homologene: 74373
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68897
Homologene: 14133
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: TR1, T1r1, Gpr70, T1R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110326
Homologene: 12888
Dazap2
Name: DAZ associated protein 2
Synonyms: gt6-12, Brbp, Prtb, Gcap28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 23994
VEGA: 15
HGNC: HGNC:2684
Homologene: 8038
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Leprel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Gm4073
Name: predicted gene 4073
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042859
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,192,340 bp
  • A to G, chromosome 1 at 85,907,029 bp
  • A to G, chromosome 1 at 162,805,179 bp
  • T to A, chromosome 1 at 183,087,644 bp
  • A to T, chromosome 2 at 117,260,231 bp
  • T to A, chromosome 2 at 152,005,740 bp
  • C to A, chromosome 2 at 160,961,291 bp
  • T to A, chromosome 3 at 38,891,627 bp
  • T to A, chromosome 3 at 107,105,193 bp
  • C to T, chromosome 4 at 55,008,411 bp
  • T to A, chromosome 4 at 86,874,598 bp
  • G to A, chromosome 4 at 94,829,970 bp
  • T to C, chromosome 4 at 103,162,431 bp
  • A to T, chromosome 4 at 108,680,976 bp
  • T to C, chromosome 4 at 126,687,037 bp
  • C to T, chromosome 4 at 137,518,940 bp
  • A to T, chromosome 4 at 143,726,846 bp
  • A to G, chromosome 4 at 148,550,152 bp
  • T to C, chromosome 4 at 152,032,157 bp
  • T to C, chromosome 5 at 62,670,979 bp
  • G to A, chromosome 5 at 96,614,904 bp
  • G to A, chromosome 5 at 109,452,966 bp
  • T to C, chromosome 6 at 18,077,146 bp
  • T to C, chromosome 6 at 43,306,008 bp
  • T to A, chromosome 6 at 57,234,148 bp
  • T to A, chromosome 6 at 60,403,557 bp
  • T to C, chromosome 6 at 63,909,045 bp
  • A to G, chromosome 7 at 8,011,086 bp
  • C to A, chromosome 7 at 44,957,929 bp
  • A to T, chromosome 7 at 47,589,432 bp
  • T to C, chromosome 7 at 80,264,521 bp
  • C to T, chromosome 7 at 126,989,703 bp
  • C to A, chromosome 8 at 3,682,848 bp
  • T to C, chromosome 8 at 105,289,961 bp
  • C to T, chromosome 9 at 40,207,494 bp
  • G to T, chromosome 9 at 105,435,140 bp
  • T to C, chromosome 9 at 108,564,956 bp
  • C to T, chromosome 10 at 27,347,054 bp
  • T to A, chromosome 10 at 60,311,161 bp
  • T to C, chromosome 10 at 75,125,111 bp
  • T to A, chromosome 11 at 74,083,700 bp
  • T to C, chromosome 11 at 85,234,676 bp
  • T to C, chromosome 11 at 112,785,154 bp
  • C to A, chromosome 12 at 103,122,353 bp
  • T to C, chromosome 13 at 9,697,690 bp
  • A to T, chromosome 14 at 48,505,304 bp
  • A to T, chromosome 14 at 49,015,480 bp
  • G to T, chromosome 14 at 49,304,301 bp
  • C to A, chromosome 14 at 52,313,803 bp
  • T to C, chromosome 15 at 58,627,522 bp
  • C to A, chromosome 15 at 100,618,090 bp
  • T to A, chromosome 16 at 26,105,221 bp
  • T to C, chromosome 16 at 38,602,335 bp
  • T to C, chromosome 16 at 44,735,829 bp
  • C to A, chromosome 17 at 21,560,197 bp
  • T to A, chromosome 17 at 21,746,821 bp
  • G to A, chromosome 17 at 32,214,782 bp
  • T to A, chromosome 17 at 32,321,931 bp
  • A to T, chromosome 17 at 38,055,272 bp
  • T to A, chromosome 17 at 42,710,122 bp
  • G to T, chromosome 17 at 55,938,926 bp
  • T to A, chromosome 17 at 70,766,043 bp
  • AGAAGCGG to AG, chromosome 18 at 12,135,941 bp
  • C to G, chromosome 18 at 31,956,337 bp
  • C to T, chromosome 18 at 36,948,091 bp
  • T to C, chromosome 18 at 89,091,896 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4273 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041645-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.