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Strain Name:
C57BL/6J-MtgxR4288Btlr/Mmmh
Stock Number:
041653-MU
Citation ID:
RRID:MMRRC_041653-MU
Other Names:
R4288 (G1), C57BL/6J-MtgxR4288Btlr
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: 2-phospho-D-glycerate hydrolase, alpha-enolase, Eno-1, MBP-1, c-Myc promoter binding protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Gpr37l1
Name: G protein-coupled receptor 37-like 1
Synonyms: CAG-18, D0Kist8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171469
Homologene: 3500
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, Mst1, sterile 20-like kinase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58231
Homologene: 55965
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213499
Homologene: 16234
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: Mms19, 2610042O15Rik, C86341, Mms19l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72199
Homologene: 41480
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Adss2
Name: adenylosuccinate synthase 2
Synonyms: AS, Adss
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329693
Homologene: 137404
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Bpnt2
Name: 3'(2'), 5'-bisphosphate nucleotidase 2
Synonyms: 1110001C20Rik, Jaws, gPAPP, Impad1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242291
Homologene: 9852
Zfp748
Name: zinc finger protein 748
Synonyms: 2610014M12Rik, mszf54, KRAB-O, Zfp208
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Exosc9
Name: exosome component 9
Synonyms: PM/Scl-75, RRP45, p6, p5, Pmscl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50911
HGNC: HGNC:9137
Homologene: 3693
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230590
Homologene: 66294
Vil1
Name: villin 1
Synonyms: Villin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22349
Homologene: 5169
Garin5b
Name: golgi associated RAB2 interactor family member 5B
Synonyms: 4930401F20Rik, Fam71e2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243822
Homologene: 89225
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241944
Homologene: 117700
Ctnna2
Name: catenin alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2, catenin (cadherin associated protein), alpha 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: BASS2, 9130401E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71592
Homologene: 32346
Stard13
Name: StAR related lipid transfer domain containing 13
Synonyms: GT650, DLC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243362
Homologene: 64844
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Acmsd
Name: amino carboxymuconate semialdehyde decarboxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266645
Homologene: 44520
Lpar5
Name: lysophosphatidic acid receptor 5
Synonyms: LOC381810, GPR93, Gpr92, LPA5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381810
Homologene: 10696
Akr7a5
Name: aldo-keto reductase family 7, member A5
Synonyms: 0610025K21Rik, Afar
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110198
Homologene: 2737
Vmn1r18
Name: vomeronasal 1 receptor 18
Synonyms: V1rc26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171199
Homologene: 138094
Vmn1r227
Name: vomeronasal 1 receptor 227
Synonyms: V1re6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171229
Gm16573
Name: predicted gene 16573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 102635191
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,418,525 bp
  • G to A, chromosome 1 at 127,738,572 bp
  • A to G, chromosome 1 at 135,161,184 bp
  • A to G, chromosome 1 at 166,403,506 bp
  • G to A, chromosome 1 at 177,776,512 bp
  • G to T, chromosome 2 at 35,030,402 bp
  • T to G, chromosome 2 at 52,259,300 bp
  • T to C, chromosome 2 at 76,810,398 bp
  • A to G, chromosome 2 at 164,099,712 bp
  • A to G, chromosome 3 at 36,159,598 bp
  • C to T, chromosome 3 at 36,563,216 bp
  • T to A, chromosome 3 at 38,891,763 bp
  • A to G, chromosome 3 at 87,442,224 bp
  • A to C, chromosome 4 at 4,778,231 bp
  • G to A, chromosome 4 at 59,690,308 bp
  • C to T, chromosome 4 at 108,184,469 bp
  • C to T, chromosome 4 at 137,518,940 bp
  • T to C, chromosome 4 at 139,314,104 bp
  • T to C, chromosome 4 at 141,167,896 bp
  • C to T, chromosome 4 at 150,245,330 bp
  • G to A, chromosome 5 at 151,045,177 bp
  • A to G, chromosome 6 at 57,390,407 bp
  • C to T, chromosome 6 at 77,605,221 bp
  • T to C, chromosome 6 at 125,081,864 bp
  • T to A, chromosome 7 at 4,770,723 bp
  • A to G, chromosome 8 at 69,794,078 bp
  • T to A, chromosome 9 at 123,183,628 bp
  • A to G, chromosome 11 at 54,337,086 bp
  • T to A, chromosome 13 at 67,541,083 bp
  • T to C, chromosome 14 at 56,607,494 bp
  • T to A, chromosome 16 at 87,397,988 bp
  • G to T, chromosome 17 at 20,735,830 bp
  • T to C, chromosome 18 at 58,035,339 bp
  • A to G, chromosome 19 at 41,945,553 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4288 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041653-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.