Strain Name:
C57BL/6J-MtgxR4356Btlr/Mmmh
Stock Number:
041669-MU
Citation ID:
RRID:MMRRC_041669-MU
Other Names:
R4356 (G1), C57BL/6J-MtgxR4356Btlr
Major Collection:

Gene Information

Fgg
Name: fibrinogen gamma chain
Synonyms: gamma-fibrinogen, 3010002H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Sall4
Name: spalt like transcription factor 4
Synonyms: 5730441M18Rik, Tex20, C330011P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99377
Homologene: 10716
E2f7
Name: E2F transcription factor 7
Synonyms: A630014C11Rik, D10Ertd739e, E2F7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52679
Homologene: 18685
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: BAF155, SRG3, msp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20588
Homologene: 68296
Mib1
Name: mindbomb E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, Mib, skeletrophin, mind bomb-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225164
Homologene: 10810
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 55935
Homologene: 9087
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22775
Homologene: 32076
Scfd1
Name: Sec1 family domain containing 1
Synonyms: STXBP1L2, RA410, 3110021P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76983
VEGA: 12
Homologene: 5650
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Fam3d
Name: FAM3 metabolism regulating signaling molecule D
Synonyms: EF-7, 2310076N21Rik, Oit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18300
VEGA: 14
Homologene: 16354
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: Rb2, p130, retinoblastoma-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74111
Homologene: 7158
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: C130069N12Rik, PTR4, PHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100561
Homologene: 26432
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434179
Homologene: 134004
Ftsj3
Name: FtsJ RNA methyltransferase homolog 3 (E. coli)
Synonyms: D11Ertd400e, C79843, Epcs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56095
Homologene: 5451
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Scube3
Name: signal peptide, CUB domain, EGF-like 3
Synonyms: D030038I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268935
Homologene: 65059
Zfp352
Name: zinc finger protein 352
Synonyms: 2czf48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 236537
Homologene: 45160
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108857
Homologene: 87006
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78016
Homologene: 15814
Olfr119
Name: olfactory receptor 119
Synonyms: MOR263-7, GA_x6K02T2PSCP-2159633-2160598
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258095
Homologene: 17195
Aadacl2fm1
Name: AADACL2 family member 1
Synonyms: C130079G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229333
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: NGC, neuroglycan C, CALEB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, mpk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243548
Homologene: 17889
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: LOC235086, AI414108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235086
Homologene: 19472
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214403
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: 1110014L01Rik, SSB1, 4930422J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74646
Homologene: 11832
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5-LOX, 5LO, 5LX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Nipsnap3a
Name: nipsnap homolog 3A
Synonyms: 1700054F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73398
Homologene: 136268
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71481
Homologene: 11849
Olfr1137
Name: olfactory receptor 1137
Synonyms: GA_x6K02T2Q125-49215724-49214792, MOR177-20, MOR40-9P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258101
Homologene: 79380
Nectin1
Name: nectin cell adhesion molecule 1
Synonyms: HIgR, HveC, PRR, PRR1, nectin-1, Cd111, Pvrl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 58235
VEGA: 9
HGNC: HGNC:9706
Homologene: 2138
Egfl7
Name: EGF-like domain 7
Synonyms: Zneu1, VE-statin, vascular endothelial-statin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353156
Homologene: 9427
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73910
Homologene: 14135
Defa30
Name: defensin, alpha, 30
Synonyms: Gm15284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100038927
Homologene: 113382
Ids
Name: iduronate 2-sulfatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15931
HGNC: HGNC:5389
Homologene: 169
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22700
Homologene: 136312
Gast
Name: gastrin
Synonyms: GAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14459
HGNC: HGNC:4164
Homologene: 628
Sun3
Name: Sad1 and UNC84 domain containing 3
Synonyms: D630047F21Rik, Sunc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 194974
Homologene: 51273
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Ifna15
Name: interferon alpha 15
Synonyms: Ifnaa, Gm12597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242517
HGNC: HGNC:5425
Homologene: 68536
Leprel4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Fbxw25
Name: F-box and WD-40 domain protein 25
Synonyms: E330001B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546160
Gm20834
Name: predicted gene, 20834
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 108168637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,353,054 bp
  • A to T, chromosome 1 at 93,265,391 bp
  • T to A, chromosome 1 at 139,732,310 bp
  • A to C, chromosome 1 at 154,443,981 bp
  • G to A, chromosome 2 at 26,590,608 bp
  • G to A, chromosome 2 at 87,711,885 bp
  • T to C, chromosome 2 at 90,758,339 bp
  • T to C, chromosome 2 at 168,755,480 bp
  • T to A, chromosome 3 at 59,936,280 bp
  • A to T, chromosome 3 at 83,012,943 bp
  • C to T, chromosome 3 at 127,729,373 bp
  • A to G, chromosome 4 at 41,413,827 bp
  • T to C, chromosome 4 at 52,995,979 bp
  • G to T, chromosome 4 at 88,557,842 bp
  • T to A, chromosome 4 at 90,223,834 bp
  • T to C, chromosome 4 at 149,906,775 bp
  • A to G, chromosome 5 at 120,140,362 bp
  • A to G, chromosome 5 at 127,604,536 bp
  • G to A, chromosome 6 at 92,207,048 bp
  • A to T, chromosome 6 at 92,411,509 bp
  • C to T, chromosome 6 at 116,420,258 bp
  • A to T, chromosome 7 at 10,490,341 bp
  • A to C, chromosome 7 at 42,661,827 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • A to T, chromosome 8 at 21,134,805 bp
  • A to G, chromosome 8 at 91,107,107 bp
  • G to A, chromosome 9 at 27,309,478 bp
  • A to G, chromosome 9 at 43,792,505 bp
  • A to T, chromosome 9 at 109,662,085 bp
  • A to G, chromosome 9 at 110,196,256 bp
  • A to G, chromosome 9 at 110,256,177 bp
  • A to G, chromosome 10 at 26,889,809 bp
  • A to T, chromosome 10 at 107,608,364 bp
  • T to C, chromosome 10 at 110,759,851 bp
  • A to G, chromosome 11 at 9,016,328 bp
  • C to A, chromosome 11 at 100,336,547 bp
  • A to G, chromosome 11 at 100,413,626 bp
  • G to A, chromosome 11 at 106,253,676 bp
  • T to A, chromosome 12 at 51,439,285 bp
  • T to C, chromosome 12 at 81,558,820 bp
  • T to A, chromosome 14 at 7,922,700 bp
  • A to G, chromosome 14 at 8,349,314 bp
  • C to T, chromosome 14 at 54,468,366 bp
  • A to G, chromosome 15 at 85,978,827 bp
  • C to T, chromosome 16 at 56,260,164 bp
  • A to T, chromosome 17 at 20,279,648 bp
  • C to A, chromosome 17 at 23,177,190 bp
  • G to A, chromosome 17 at 28,164,309 bp
  • G to T, chromosome 17 at 37,700,899 bp
  • A to G, chromosome 17 at 73,915,690 bp
  • A to G, chromosome 18 at 10,751,844 bp
  • A to T, chromosome 18 at 36,643,043 bp
  • C to T, chromosome 18 at 37,687,611 bp
  • C to A, chromosome 19 at 37,411,435 bp
  • C to A, chromosome X at 70,346,344 bp
  • T to A, chromosome Y at 10,322,962 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4356 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041669-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.