Strain Name:
C57BL/6J-MtgxR4359Btlr/Mmmh
Stock Number:
041670-MU
Citation ID:
RRID:MMRRC_041670-MU
Other Names:
R4359 (G1), C57BL/6J-MtgxR4359Btlr
Major Collection:

Gene Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, Rxrip13, 5730405M06Rik, N-CoR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Srd5a3
Name: steroid 5 alpha-reductase 3
Synonyms: 1110025P14Rik, D730040M03Rik, Srd5a2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57357
Homologene: 41385
Crlf3
Name: cytokine receptor-like factor 3
Synonyms: Creme9, cytor4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54394
Homologene: 9327
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, Fam188a, 2310047O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66960
Homologene: 11478
Psmd13
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
Synonyms: S11, 26S proteasome subunit p40.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23997
HGNC: HGNC:9558
Homologene: 2110
Htr1b
Name: 5-hydroxytryptamine (serotonin) receptor 1B
Synonyms: 5-HT1B receptor, 5HT1B receptor, 5-HT1B receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15551
HGNC: HGNC:5287
Homologene: 669
Mapkapk3
Name: mitogen-activated protein kinase-activated protein kinase 3
Synonyms: MK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102626
HGNC: HGNC:6888
Homologene: 55836
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21853
Homologene: 31206
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71472
Homologene: 41730
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: Mcpr, 2610021O03Rik, tsg24, Apc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: 2810431N21Rik, PEPP2, AMH-Cre, Ayu21-9, Tg(AMH-cre)1Flor, Gt(Ayu21)9Imeg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237339
Homologene: 18226
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277939
Homologene: 19524
Cep135
Name: centrosomal protein 135
Synonyms: Cep4, LOC381644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Malt1
Name: MALT1 paracaspase
Synonyms: D430033E09Rik, Pcasp1, paracaspase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, mGlu7a receptor, Tg(SMN2)89Ahmb, 6330570A01Rik, mGluR7, SMN2, E130018M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Cxcl16
Name: chemokine (C-X-C motif) ligand 16
Synonyms: Scavenger Receptor, SR-PSOX, 0910001K24Rik, SR-PSOX/CXCL16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66102
Homologene: 49694
R3hcc1l
Name: R3H domain and coiled-coil containing 1 like
Synonyms: 1700036B12Rik, D19Ertd386e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52013
Homologene: 8707
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: PTR4, PHT1, C130069N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100561
Homologene: 26432
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101568
Homologene: 9509
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231386
Homologene: 15796
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
H2-K1
Name: histocompatibility 2, K1, K region
Synonyms: H-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14972
HGNC: HGNC:4931
Homologene: 128352
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Stxbp4
Name: syntaxin binding protein 4
Synonyms: Synip, 6030470M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20913
Homologene: 7963
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Gm11639
Name: predicted gene 11639
Synonyms: Efcab15, Gm11639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 105242472
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Pilra
Name: paired immunoglobin-like type 2 receptor alpha
Synonyms: FDF03
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231805
Homologene: 8387
Olfr616
Name: olfactory receptor 616
Synonyms: MOR19-1, GA_x6K02T2PBJ9-6289676-6288723
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259103
Homologene: 64957
Acot1
Name: acyl-CoA thioesterase 1
Synonyms: Cte1, CTE-1, ACH2, CTE-I, D12Ucla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26897
VEGA: 12
Homologene: 22686
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: LOC235086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235086
Homologene: 19472
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18080
Homologene: 40632
Disp3
Name: dispatched RND transporter family member 3
Synonyms: G630052C06Rik, Ptchd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242748
Homologene: 25712
Klhl25
Name: kelch-like 25
Synonyms: 2810402K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207952
Homologene: 32546
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: SSB1, 1110014L01Rik, 4930422J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74646
Homologene: 11832
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109082
Homologene: 82571
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: 2810432N10Rik, A530086E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218294
VEGA: 13
HGNC: HGNC:1719
Homologene: 104197
Olfr16
Name: olfactory receptor 16
Synonyms: MOR267-13, GA_x6K02T2R7CC-893157-892228, MOR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18313
Homologene: 7460
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170483
Homologene: 15606
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216622
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: 6330417G04Rik, Grf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: Nec-1, Phpp-1, SPC3, PC1, PC3, prohormone convertase 1/3, Nec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Gfod2
Name: glucose-fructose oxidoreductase domain containing 2
Synonyms: 5730466C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70575
Homologene: 10361
4930544M13Rik
Name: RIKEN cDNA 4930544M13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75161
Prps2
Name: phosphoribosyl pyrophosphate synthetase 2
Synonyms: Prps-2, 2610101M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 110639
HGNC: HGNC:9465
Homologene: 128301
Ifna15
Name: interferon alpha 15
Synonyms: Gm12597, Ifnaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242517
HGNC: HGNC:5425
Homologene: 68536
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 172,957,080 bp
  • A to T, chromosome 2 at 12,396,209 bp
  • A to C, chromosome 2 at 40,903,065 bp
  • A to G, chromosome 2 at 59,901,613 bp
  • A to G, chromosome 2 at 128,623,556 bp
  • T to A, chromosome 3 at 62,475,278 bp
  • A to G, chromosome 4 at 41,413,827 bp
  • G to T, chromosome 4 at 88,557,842 bp
  • T to C, chromosome 4 at 148,271,932 bp
  • T to C, chromosome 4 at 149,906,775 bp
  • T to A, chromosome 5 at 76,147,700 bp
  • G to T, chromosome 5 at 76,611,714 bp
  • T to C, chromosome 5 at 86,831,995 bp
  • A to G, chromosome 5 at 127,604,536 bp
  • T to C, chromosome 5 at 137,831,314 bp
  • G to T, chromosome 6 at 110,646,348 bp
  • G to C, chromosome 6 at 140,591,688 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • T to C, chromosome 7 at 75,866,732 bp
  • T to G, chromosome 7 at 100,441,089 bp
  • A to G, chromosome 7 at 103,564,535 bp
  • G to T, chromosome 7 at 140,889,505 bp
  • T to C, chromosome 8 at 95,739,848 bp
  • T to C, chromosome 8 at 105,717,545 bp
  • G to A, chromosome 9 at 27,309,478 bp
  • C to A, chromosome 9 at 81,632,351 bp
  • T to A, chromosome 9 at 95,951,536 bp
  • A to T, chromosome 9 at 107,284,953 bp
  • T to C, chromosome 9 at 108,496,145 bp
  • A to G, chromosome 10 at 26,327,741 bp
  • T to A, chromosome 10 at 79,972,897 bp
  • C to A, chromosome 10 at 128,247,342 bp
  • G to T, chromosome 11 at 9,297,629 bp
  • A to T, chromosome 11 at 29,824,669 bp
  • T to C, chromosome 11 at 62,358,910 bp
  • C to A, chromosome 11 at 70,458,805 bp
  • T to A, chromosome 11 at 72,823,508 bp
  • T to C, chromosome 11 at 80,059,374 bp
  • C to T, chromosome 11 at 90,494,644 bp
  • G to T, chromosome 11 at 104,733,721 bp
  • T to A, chromosome 12 at 70,014,938 bp
  • T to C, chromosome 12 at 84,014,540 bp
  • T to A, chromosome 13 at 50,433,337 bp
  • T to A, chromosome 13 at 64,248,411 bp
  • T to C, chromosome 13 at 75,112,719 bp
  • C to A, chromosome 13 at 91,890,677 bp
  • T to A, chromosome 13 at 114,607,488 bp
  • G to A, chromosome 15 at 27,749,797 bp
  • C to T, chromosome 17 at 33,999,816 bp
  • T to C, chromosome 18 at 65,476,229 bp
  • A to T, chromosome 19 at 34,573,144 bp
  • T to A, chromosome 19 at 42,582,779 bp
  • T to A, chromosome X at 167,363,549 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.