Strain Name:
C57BL/6J-MtgxR4373Btlr/Mmmh
Stock Number:
041675-MU
Citation ID:
RRID:MMRRC_041675-MU
Other Names:
R4373 (G1), C57BL/6J-MtgxR4373Btlr
Major Collection:

Gene Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: SSE, PRCE, separase, Cerp, ESP1, PRCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: Wdt4, ANKRD4, C130078N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228852
Homologene: 9194
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: Rutbc2, D5Bwg1524e, 2410098H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52850
Homologene: 64485
Nmt1
Name: N-myristoyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18107
HGNC: HGNC:7857
Homologene: 69027
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: Soga2, 1110012J17Rik, t8219b25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68617
Homologene: 41017
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57258
Homologene: 10733
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21778
Homologene: 32072
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Opa3
Name: optic atrophy 3
Synonyms: LOC384570, LOC243868, D630048P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 403187
HGNC: HGNC:8142
Homologene: 57022
Myc
Name: myelocytomatosis oncogene
Synonyms: Myc2, Nird, bHLHe39, Niard, c-myc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17869
HGNC: HGNC:7553
Homologene: 31092
Esam
Name: endothelial cell-specific adhesion molecule
Synonyms: 2310008D05Rik, W117m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69524
Homologene: 12316
Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13870
HGNC: HGNC:3433
Homologene: 1501
Hk1
Name: hexokinase 1
Synonyms: mHk1-s, Hk-1, Hk1-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Marchf11
Name: membrane associated ring-CH-type finger 11
Synonyms: March11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 211147
Homologene: 45584
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244152
Homologene: 41045
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Rai17, Zimp10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328365
Homologene: 10667
Dach1
Name: dachshund family transcription factor 1
Synonyms: E130112M23Rik, Dac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: Myhc-a, cardiomyopathy, hypertrophic 1, alpha cardiac MHC, alphaMHC, alpha myosin, A830009F23Rik, alpha-MHC, Myhca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619697
Homologene: 86604
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20849
Homologene: 20679
H2-M10.6
Name: histocompatibility 2, M region locus 10.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 399549
Homologene: 117973
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, colony-stimulating factor-1, M-CSF, Csfm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 207792
Homologene: 19490
Prdm8
Name: PR domain containing 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77630
Homologene: 129760
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, mSNM1, SMN1a, 2810043H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 55947
Homologene: 8920
Pld5
Name: phospholipase D family, member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319455
Homologene: 16081
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Gde1
Name: glycerophosphodiester phosphodiesterase 1
Synonyms: MIR16, 1200003M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56209
Homologene: 41149
Gm16069
Name: predicted gene 16069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102636781
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A5, UT-A3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
0610010F05Rik
Name: RIKEN cDNA 0610010F05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71675
Homologene: 19038
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: Asahl, 3830414F09Rik, 2210023K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384220
Homologene: 104825
Gm10382
Name: predicted gene 10382
Synonyms: EG639281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Olfr1228
Name: olfactory receptor 1228
Synonyms: MOR233-1, GA_x6K02T2Q125-50696209-50695274
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258973
Homologene: 74217
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 668101
Homologene: 82993
Lrtm2
Name: leucine-rich repeats and transmembrane domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 211187
Homologene: 65244
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57745
Homologene: 49338
Akr1b3
Name: aldo-keto reductase family 1, member B3 (aldose reductase)
Synonyms: Ahr-1, Ahr1, Aldr1, ALR2, AR, Aldor1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268822
Homologene: 34378
Ctsz
Name: cathepsin Z
Synonyms: cathepsin X, CTSX, D2Wsu143e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64138
HGNC: HGNC:2547
Homologene: 1022
Pfn4
Name: profilin family, member 4
Synonyms: 2900024P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382562
VEGA: 12
Homologene: 20046
Rpl11
Name: ribosomal protein L11
Synonyms: 2010203J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67025
Homologene: 37376
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,071,941 bp
  • T to C, chromosome 1 at 144,247,906 bp
  • T to C, chromosome 1 at 155,226,158 bp
  • T to A, chromosome 1 at 176,140,017 bp
  • A to G, chromosome 2 at 31,898,232 bp
  • T to C, chromosome 2 at 89,249,245 bp
  • A to T, chromosome 2 at 127,805,236 bp
  • T to C, chromosome 2 at 158,761,765 bp
  • T to C, chromosome 2 at 174,428,585 bp
  • A to T, chromosome 3 at 15,548,761 bp
  • G to A, chromosome 3 at 89,181,927 bp
  • T to A, chromosome 3 at 107,756,739 bp
  • A to G, chromosome 4 at 82,323,658 bp
  • G to A, chromosome 4 at 135,929,950 bp
  • G to A, chromosome 4 at 136,051,143 bp
  • T to C, chromosome 5 at 92,278,143 bp
  • T to C, chromosome 5 at 98,186,508 bp
  • A to T, chromosome 5 at 109,363,801 bp
  • TTTTATATT to TTT, chromosome 5 at 113,258,123 bp
  • A to G, chromosome 5 at 125,389,583 bp
  • A to T, chromosome 6 at 7,677,978 bp
  • A to C, chromosome 6 at 34,304,267 bp
  • A to G, chromosome 6 at 119,320,528 bp
  • C to T, chromosome 7 at 19,244,774 bp
  • G to A, chromosome 7 at 19,347,132 bp
  • T to A, chromosome 7 at 24,125,048 bp
  • T to C, chromosome 7 at 98,352,831 bp
  • A to G, chromosome 7 at 118,698,558 bp
  • C to T, chromosome 9 at 37,534,196 bp
  • A to T, chromosome 9 at 72,480,595 bp
  • C to A, chromosome 10 at 62,315,540 bp
  • A to T, chromosome 11 at 23,615,265 bp
  • A to G, chromosome 11 at 103,043,200 bp
  • T to A, chromosome 12 at 4,770,182 bp
  • T to C, chromosome 14 at 25,636,010 bp
  • T to A, chromosome 14 at 49,770,436 bp
  • T to A, chromosome 14 at 54,962,108 bp
  • G to A, chromosome 14 at 57,591,022 bp
  • G to A, chromosome 14 at 97,827,750 bp
  • CT to CTTGGATT, chromosome 15 at 10,537,562 bp
  • G to A, chromosome 15 at 10,537,566 bp
  • A to G, chromosome 15 at 26,309,446 bp
  • A to T, chromosome 15 at 61,989,664 bp
  • A to C, chromosome 15 at 76,183,117 bp
  • A to G, chromosome 15 at 76,594,335 bp
  • A to G, chromosome 15 at 102,312,989 bp
  • G to T, chromosome 16 at 37,013,181 bp
  • A to C, chromosome 17 at 23,401,421 bp
  • T to C, chromosome 17 at 36,813,066 bp
  • T to A, chromosome 17 at 66,380,079 bp
  • G to A, chromosome 18 at 78,207,068 bp
  • A to G, chromosome 19 at 56,545,442 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4373 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041675-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.