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Strain Name:
C57BL/6J-MtgxR4373Btlr/Mmmh
Stock Number:
041675-MU
Citation ID:
RRID:MMRRC_041675-MU
Other Names:
R4373 (G1), C57BL/6J-MtgxR4373Btlr
Major Collection:

Strain Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: PRCE, separase, SSE, ESP1, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Nmt1
Name: N-myristoyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18107
HGNC: HGNC:7857
Homologene: 69027
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21778
Homologene: 32072
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Opa3
Name: optic atrophy 3
Synonyms: LOC243868, LOC384570, D630048P19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 403187
HGNC: HGNC:8142
Homologene: 57022
Myc
Name: myelocytomatosis oncogene
Synonyms: c-myc, Nird, Niard, Myc2, bHLHe39
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17869
HGNC: HGNC:7553
Homologene: 31092
Esam
Name: endothelial cell-specific adhesion molecule
Synonyms: W117m, 2310008D05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69524
Homologene: 12316
Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13870
HGNC: HGNC:3433
Homologene: 1501
Hk1
Name: hexokinase 1
Synonyms: Hk-1, mHk1-s, Hk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Marchf11
Name: membrane associated ring-CH-type finger 11
Synonyms: March11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211147
Homologene: 45584
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244152
Homologene: 41045
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67419
Homologene: 12127
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Rai17, Zimp10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328365
Homologene: 10667
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619697
Homologene: 86604
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, M-CSF, colony-stimulating factor-1, Csfm, BAP025
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Asns
Name: asparagine synthetase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 207792
Homologene: 19490
Prdm8
Name: PR domain containing 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77630
Homologene: 129760
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: mSNM1, SNM1, 2810043H12Rik, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
Pld5
Name: phospholipase D family member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319455
Homologene: 16081
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Gde1
Name: glycerophosphodiester phosphodiesterase 1
Synonyms: 1200003M13Rik, MIR16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56209
Homologene: 41149
Gm16069
Name: predicted gene 16069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102636781
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Sanbr
Name: SANT and BTB domain regulator of CSR
Synonyms: 0610010F05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71675
Homologene: 19038
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: 2210023K21Rik, 3830414F09Rik, Asahl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Gm10382
Name: predicted gene 10382
Synonyms: EG639281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 639281
Or4c122
Name: olfactory receptor family 4 subfamily C member 122
Synonyms: GA_x6K02T2Q125-50696209-50695274, MOR233-1, Olfr1228
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258973
Homologene: 74217
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668101
Homologene: 82993
Lrtm2
Name: leucine-rich repeats and transmembrane domains 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211187
Homologene: 65244
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Akr1b1
Name: aldo-keto reductase family 1 member B
Synonyms: Ahr-1, Ahr1, Aldor1, Aldr1, ALR2, AR, Akr1b3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268822
Homologene: 34378
Ctsz
Name: cathepsin Z
Synonyms: CTSX, cathepsin X, D2Wsu143e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64138
HGNC: HGNC:2547
Homologene: 1022
Pfn4
Name: profilin family, member 4
Synonyms: 2900024P18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382562
VEGA: 12
Homologene: 20046
Rpl11
Name: ribosomal protein L11
Synonyms: 2010203J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67025
Homologene: 37376
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,071,941 bp
  • T to C, chromosome 1 at 144,247,906 bp
  • T to C, chromosome 1 at 155,226,158 bp
  • T to A, chromosome 1 at 176,140,017 bp
  • A to G, chromosome 2 at 31,898,232 bp
  • T to C, chromosome 2 at 89,249,245 bp
  • A to T, chromosome 2 at 127,805,236 bp
  • T to C, chromosome 2 at 158,761,765 bp
  • T to C, chromosome 2 at 174,428,585 bp
  • A to T, chromosome 3 at 15,548,761 bp
  • G to A, chromosome 3 at 89,181,927 bp
  • T to A, chromosome 3 at 107,756,739 bp
  • A to G, chromosome 4 at 82,323,658 bp
  • G to A, chromosome 4 at 135,929,950 bp
  • G to A, chromosome 4 at 136,051,143 bp
  • T to C, chromosome 5 at 92,278,143 bp
  • T to C, chromosome 5 at 98,186,508 bp
  • A to T, chromosome 5 at 109,363,801 bp
  • TTTTATATT to TTT, chromosome 5 at 113,258,123 bp
  • A to G, chromosome 5 at 125,389,583 bp
  • A to T, chromosome 6 at 7,677,978 bp
  • A to C, chromosome 6 at 34,304,267 bp
  • A to G, chromosome 6 at 119,320,528 bp
  • C to T, chromosome 7 at 19,244,774 bp
  • G to A, chromosome 7 at 19,347,132 bp
  • T to A, chromosome 7 at 24,125,048 bp
  • T to C, chromosome 7 at 98,352,831 bp
  • A to G, chromosome 7 at 118,698,558 bp
  • C to T, chromosome 9 at 37,534,196 bp
  • A to T, chromosome 9 at 72,480,595 bp
  • C to A, chromosome 10 at 62,315,540 bp
  • A to T, chromosome 11 at 23,615,265 bp
  • A to G, chromosome 11 at 103,043,200 bp
  • T to A, chromosome 12 at 4,770,182 bp
  • T to C, chromosome 14 at 25,636,010 bp
  • T to A, chromosome 14 at 49,770,436 bp
  • T to A, chromosome 14 at 54,962,108 bp
  • G to A, chromosome 14 at 57,591,022 bp
  • G to A, chromosome 14 at 97,827,750 bp
  • CT to CTTGGATT, chromosome 15 at 10,537,562 bp
  • G to A, chromosome 15 at 10,537,566 bp
  • A to G, chromosome 15 at 26,309,446 bp
  • A to T, chromosome 15 at 61,989,664 bp
  • A to C, chromosome 15 at 76,183,117 bp
  • A to G, chromosome 15 at 76,594,335 bp
  • A to G, chromosome 15 at 102,312,989 bp
  • G to T, chromosome 16 at 37,013,181 bp
  • A to C, chromosome 17 at 23,401,421 bp
  • T to C, chromosome 17 at 36,813,066 bp
  • T to A, chromosome 17 at 66,380,079 bp
  • G to A, chromosome 18 at 78,207,068 bp
  • A to G, chromosome 19 at 56,545,442 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4373 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041675-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.