Strain Name:
C57BL/6J-MtgxR4407Btlr/Mmmh
Stock Number:
041689-MU
Citation ID:
RRID:MMRRC_041689-MU
Other Names:
R4407 (G1), C57BL/6J-MtgxR4407Btlr
Major Collection:

Gene Information

Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22612
Homologene: 55900
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Wnk3
Name: WNK lysine deficient protein kinase 3
Synonyms: Prkwnk3, Wnk3-ps, Wnk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 279561
Homologene: 32493
Fkbp3
Name: FK506 binding protein 3
Synonyms: FKBP25, 25kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 30795
VEGA: 12
HGNC: HGNC:3719
Homologene: 1525
Mysm1
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, C130067A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320713
Homologene: 66204
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Rrp12
Name: ribosomal RNA processing 12 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107094
VEGA: 19
Homologene: 22370
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 277854
Homologene: 34718
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Braf
Name: Braf transforming gene
Synonyms: Braf-2, Braf2, 9930012E13Rik, D6Ertd631e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Snrpb
Name: small nuclear ribonucleoprotein B
Synonyms: SNRNP-B, SM11, SMB, SM-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20638
Homologene: 134543
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Golga1
Name: golgi autoantigen, golgin subfamily a, 1
Synonyms: golgin-97, 0710001G09Rik, 2210418B03Rik, Golgi97, awag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Zdhhc15
Name: zinc finger, DHHC domain containing 15
Synonyms: 6030457O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 108672
Homologene: 81788
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27054
Homologene: 74571
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237339
Homologene: 18226
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Synonyms: Zpk, DLK, MUK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26404
HGNC: HGNC:6851
Homologene: 4592
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, eyes2, crf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328110
Homologene: 32377
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330554
Homologene: 45598
E2f5
Name: E2F transcription factor 5
Synonyms: E2F-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13559
HGNC: HGNC:3119
Homologene: 1472
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Fbln1
Name: fibulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Trmt1
Name: tRNA methyltransferase 1
Synonyms: 6720406L13Rik, D8Ertd812e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212528
Homologene: 5632
Dolpp1
Name: dolichyl pyrophosphate phosphatase 1
Synonyms: LSFR2, 0610011H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57170
Homologene: 10663
Cpped1
Name: calcineurin-like phosphoesterase domain containing 1
Synonyms: C530044N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223978
Homologene: 10142
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380664
Homologene: 8633
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Crip3
Name: cysteine-rich protein 3
Synonyms: TLP-A, TLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 114570
Homologene: 28039
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73707
Homologene: 44544
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, NIR3, Rdgb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19679
Homologene: 7915
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
Bbs10
Name: Bardet-Biedl syndrome 10 (human)
Synonyms: 1300007O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545934
Homologene: 79577
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, D330013L20Rik, Wdr67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210544
Homologene: 17089
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546913
Homologene: 84037
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 107868
Homologene: 68408
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: experimental autoimmune prostatitis antigen 1, Eapa1, 9530008N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 331046
Homologene: 20689
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9030623B18Rik, 9130013M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Olfr1178
Name: olfactory receptor 1178
Synonyms: GA_x6K02T2Q125-49870417-49871388, MOR225-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258203
Homologene: 73979
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Trim38
Name: tripartite motif-containing 38
Synonyms: LOC214158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 214158
Homologene: 48427
Cep112
Name: centrosomal protein 112
Synonyms: 1700001M19Rik, 1700029K01Rik, 8430407H02Rik, Macoco, Ccdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76380
Homologene: 44915
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232334
Homologene: 18603
Tm4sf19
Name: transmembrane 4 L six family member 19
Synonyms: EG277203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 277203
Homologene: 64632
Slc2a10
Name: solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms: Glut10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170441
Homologene: 38551
Acad8
Name: acyl-Coenzyme A dehydrogenase family, member 8
Synonyms: 2310016C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66948
HGNC: HGNC:87
Homologene: 8662
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Gm6430
Name: predicted gene 6430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 623430
BC053393
Name: cDNA sequence BC053393
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 407814
Homologene: 86792
RP23-455B5.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
D030055H07Rik
Name: RIKEN cDNA D030055H07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 654798
Bcl6b
Name: B cell CLL/lymphoma 6, member B
Synonyms: Bazf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12029
HGNC: HGNC:1002
Homologene: 7243
Gm11649
Name: predicted gene 11649
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 6,827,837 bp
  • G to C, chromosome 1 at 85,577,202 bp
  • T to C, chromosome 1 at 97,025,572 bp
  • C to T, chromosome 2 at 30,396,452 bp
  • C to A, chromosome 2 at 39,019,641 bp
  • A to T, chromosome 2 at 69,502,517 bp
  • A to T, chromosome 2 at 88,392,083 bp
  • A to C, chromosome 2 at 122,075,332 bp
  • A to G, chromosome 2 at 130,172,712 bp
  • A to T, chromosome 2 at 144,574,718 bp
  • T to A, chromosome 2 at 165,514,764 bp
  • T to A, chromosome 3 at 14,603,763 bp
  • A to T, chromosome 3 at 38,958,540 bp
  • G to T, chromosome 3 at 93,214,869 bp
  • C to A, chromosome 3 at 93,692,112 bp
  • A to T, chromosome 4 at 82,912,603 bp
  • C to T, chromosome 4 at 86,341,190 bp
  • T to C, chromosome 4 at 94,965,212 bp
  • T to G, chromosome 5 at 32,640,585 bp
  • T to A, chromosome 5 at 32,904,534 bp
  • T to A, chromosome 5 at 76,624,667 bp
  • T to A, chromosome 5 at 124,152,615 bp
  • T to G, chromosome 6 at 39,615,720 bp
  • A to G, chromosome 6 at 48,460,520 bp
  • C to T, chromosome 6 at 114,890,612 bp
  • C to T, chromosome 6 at 123,637,954 bp
  • T to A, chromosome 7 at 23,703,016 bp
  • A to G, chromosome 7 at 64,372,631 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • T to A, chromosome 8 at 84,697,755 bp
  • A to T, chromosome 9 at 27,003,597 bp
  • A to T, chromosome 9 at 106,157,108 bp
  • A to T, chromosome 9 at 123,056,530 bp
  • A to G, chromosome 10 at 26,313,884 bp
  • AATCAGACAGGAG to A, chromosome 10 at 27,212,128 bp
  • T to C, chromosome 10 at 76,374,870 bp
  • A to G, chromosome 10 at 111,299,859 bp
  • A to T, chromosome 10 at 120,925,430 bp
  • A to G, chromosome 11 at 46,577,380 bp
  • A to G, chromosome 11 at 70,226,103 bp
  • T to C, chromosome 11 at 107,532,055 bp
  • C to T, chromosome 11 at 108,519,201 bp
  • A to G, chromosome 12 at 31,450,859 bp
  • C to T, chromosome 12 at 65,056,266 bp
  • T to C, chromosome 12 at 65,070,004 bp
  • A to C, chromosome 13 at 23,791,491 bp
  • T to A, chromosome 14 at 52,147,399 bp
  • A to T, chromosome 14 at 103,287,228 bp
  • T to A, chromosome 15 at 57,920,042 bp
  • T to A, chromosome 15 at 85,231,556 bp
  • T to C, chromosome 15 at 102,505,402 bp
  • T to C, chromosome 16 at 11,805,421 bp
  • T to C, chromosome 16 at 32,407,894 bp
  • A to T, chromosome 17 at 46,431,280 bp
  • C to A, chromosome 17 at 78,983,558 bp
  • G to T, chromosome 18 at 37,144,446 bp
  • A to T, chromosome 19 at 30,086,249 bp
  • A to G, chromosome 19 at 37,922,978 bp
  • T to C, chromosome 19 at 41,892,551 bp
  • A to T, chromosome 19 at 55,237,837 bp
  • G to A, chromosome X at 104,560,688 bp
  • C to A, chromosome X at 151,233,213 bp
  • T to C, chromosome Y at 1,336,375 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4407 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041689-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.