Strain Name:
C57BL/6J-MtgxR4410Btlr/Mmmh
Stock Number:
041692-MU
Citation ID:
RRID:MMRRC_041692-MU
Other Names:
R4410 (G1), C57BL/6J-MtgxR4410Btlr
Major Collection:

Gene Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68310
Homologene: 32904
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75914
Homologene: 44781
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Spag7
Name: sperm associated antigen 7
Synonyms: FSA-1, Fsa1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216873
Homologene: 3595
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223666
Homologene: 27825
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Slc37a3
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Synonyms: 2610507O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72144
Homologene: 41740
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: nucling, 2700059D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Cdca4
Name: cell division cycle associated 4
Synonyms: 2410018C03Rik, Hepp, SEI-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71963
VEGA: 12
Homologene: 9936
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269470
Homologene: 4937
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: noxin, 4632434I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74041
Homologene: 51655
Pals2
Name: protein associated with LIN7 2, MAGUK family member
Synonyms: P55t, Pals2, Mpp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56524
Homologene: 22976
St7
Name: suppression of tumorigenicity 7
Synonyms: RAY1, HELG, SEN4, TSG7, Fam4a2, 9430001H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, Tex190, 9430095H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Eme2
Name: essential meiotic structure-specific endonuclease subunit 2
Synonyms: 2810013J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193838
Homologene: 19180
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56523
Homologene: 23182
Rin2
Name: Ras and Rab interactor 2
Synonyms: RASSF4, 4632403N06Rik, 2010003K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Arrb1
Name: arrestin, beta 1
Synonyms: 1200006I17Rik, beta-arrestin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109689
HGNC: HGNC:711
Homologene: 2981
Iqcg
Name: IQ motif containing G
Synonyms: G1-374-12, stubby12d, repro1, 2400003L07Rik, esgd12d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69707
Homologene: 32776
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: MyHC-emb, Myhs-e, Myhse
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Or4c102
Name: olfactory receptor family 4 subfamily C member 102
Synonyms: GA_x6K02T2Q125-50079044-50079964, MOR237-2, Olfr1189
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258768
Homologene: 81569
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382106
Homologene: 110776
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: SERA, PGDH, PGD, PGAD, A10, 3-PGDH, 3PGDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Usp43
Name: ubiquitin specific peptidase 43
Synonyms: C630032K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216835
Homologene: 129879
Herc6
Name: hect domain and RLD 6
Synonyms: 4930427L17Rik, 1700121D12Rik, CEB1, 2510038N07Rik, Herc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Nkain3
Name: Na+/K+ transporting ATPase interacting 3
Synonyms: E130310K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269513
Homologene: 18265
Vmn1r55
Name: vomeronasal 1 receptor 55
Synonyms: LOC236535, LOC384522, V1rd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384522
Homologene: 41799
Folr2
Name: folate receptor 2 (fetal)
Synonyms: FBP2, Folbp2, FR-P3, Folbp-2, Folbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14276
Homologene: 627
Leprel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Gm11457
Name: predicted gene 11457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm21846
Name: predicted gene, 21846
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Pramel41
Name: PRAME like 41
Synonyms: Gm31009, Gm7682
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 102633100
E430024P14Rik
Name: RIKEN cDNA E430024P14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 40,665,082 bp
  • G to A, chromosome 2 at 88,592,421 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • A to G, chromosome 2 at 164,767,819 bp
  • A to G, chromosome 3 at 98,314,275 bp
  • G to A, chromosome 3 at 100,140,227 bp
  • A to G, chromosome 4 at 20,778,284 bp
  • A to T, chromosome 4 at 127,048,104 bp
  • A to G, chromosome 5 at 22,775,692 bp
  • A to T, chromosome 5 at 94,445,861 bp
  • C to T, chromosome 6 at 17,854,933 bp
  • A to C, chromosome 6 at 24,604,630 bp
  • T to A, chromosome 6 at 39,338,813 bp
  • C to T, chromosome 6 at 50,198,268 bp
  • T to A, chromosome 6 at 57,659,679 bp
  • G to A, chromosome 6 at 84,851,886 bp
  • A to G, chromosome 7 at 5,147,076 bp
  • A to G, chromosome 7 at 92,858,079 bp
  • G to T, chromosome 7 at 99,598,296 bp
  • T to C, chromosome 7 at 101,840,674 bp
  • T to G, chromosome 7 at 130,742,211 bp
  • T to A, chromosome 7 at 141,637,663 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • G to A, chromosome 8 at 109,532,063 bp
  • C to A, chromosome 9 at 42,003,992 bp
  • T to G, chromosome 9 at 60,869,891 bp
  • A to T, chromosome 9 at 109,608,188 bp
  • A to G, chromosome 10 at 127,742,827 bp
  • T to C, chromosome 11 at 66,085,477 bp
  • G to C, chromosome 11 at 67,085,032 bp
  • T to C, chromosome 11 at 67,855,890 bp
  • T to C, chromosome 11 at 70,664,862 bp
  • T to A, chromosome 12 at 41,452,584 bp
  • C to T, chromosome 12 at 76,094,393 bp
  • A to T, chromosome 12 at 112,821,879 bp
  • A to G, chromosome 14 at 12,822,323 bp
  • T to C, chromosome 14 at 103,135,266 bp
  • A to T, chromosome 15 at 76,725,512 bp
  • T to G, chromosome 16 at 20,655,026 bp
  • G to C, chromosome 16 at 26,105,290 bp
  • T to G, chromosome 16 at 33,030,816 bp
  • A to G, chromosome 16 at 36,500,341 bp
  • A to G, chromosome 17 at 7,946,127 bp
  • T to A, chromosome 17 at 12,248,998 bp
  • A to G, chromosome 17 at 24,893,624 bp
  • T to A, chromosome 18 at 63,778,249 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4410 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041692-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.