Strain Name:
C57BL/6J-MtgxR4414Btlr/Mmmh
Stock Number:
041694-MU
Citation ID:
RRID:MMRRC_041694-MU
Other Names:
R4414 (G1), C57BL/6J-MtgxR4414Btlr
Major Collection:

Gene Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20464
VEGA: 10
Homologene: 3715
Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Gm4392, Ank-2, ankyrin B, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109676
HGNC: HGNC:493
Aco2
Name: aconitase 2, mitochondrial
Synonyms: Aco3, D10Wsu183e, Aco-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11429
HGNC: HGNC:118
Homologene: 856
Ktn1
Name: kinectin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16709
HGNC: HGNC:6467
Homologene: 7397
Dnm1l
Name: dynamin 1-like
Synonyms: Dnmlp1, 6330417M19Rik, Drp1, python
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Mll1, All1, HTRX1, ALL-1, trithorax Drosophila, Cxxc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: GOLTC1, GTC90, 5430405C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238123
VEGA: 12
Homologene: 42221
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: B130055N23Rik, TFIIIB90, TAF3B1, Tfnr, G630013P12Rik, TFIIIB150, TFC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 544971
Homologene: 34582
Mnat1
Name: menage a trois 1
Synonyms: E130115E11Rik, MAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Wdr26
Name: WD repeat domain 26
Synonyms: Gid7, 1600024A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226757
Homologene: 11857
Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Synonyms: 1110055K06Rik, Rock-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 19877
VEGA: 18
Homologene: 55899
Rho
Name: rhodopsin
Synonyms: L opsin, Ops, LWS opsin, Long Wavelength Sensitive opsin, opsin 2, Rod Opsin, Opn2, Red Opsin, RP4, Noerg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 212541
Homologene: 68068
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 404710
Homologene: 26400
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 665775
Homologene: 45109
Gpx8
Name: glutathione peroxidase 8 (putative)
Synonyms: 2310016C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69590
VEGA: 13
Homologene: 88454
Oit3
Name: oncoprotein induced transcript 3
Synonyms: EF-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18302
Homologene: 7870
Src
Name: Rous sarcoma oncogene
Synonyms: pp60c-src
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20779
Homologene: 21120
Eloa
Name: elongin A
Synonyms: Tceb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 27224
Homologene: 37746
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216177
Homologene: 87560
Dse
Name: dermatan sulfate epimerase
Synonyms: B130024B19Rik, DS-epi1, Sart2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 212898
VEGA: 10
Homologene: 8354
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329502
Homologene: 65339
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, crash, Adgrc1, Crsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Mlxipl
Name: MLX interacting protein-like
Synonyms: bHLHd14, WS-bHLH, Wbscr14, ChREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 58805
Homologene: 32507
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: Ccdc147, LOC381229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 381229
VEGA: 19
Homologene: 77312
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, 5930404L04Rik, Fip200, Cc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12421
Homologene: 7659
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: A330097D03Rik, Erk3-related, p63Mapk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Acss1
Name: acyl-CoA synthetase short-chain family member 1
Synonyms: AceCS2, Acas2, Acas2l, 1110032O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68738
Homologene: 56037
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330485
Homologene: 18333
Naaladl1
Name: N-acetylated alpha-linked acidic dipeptidase-like 1
Synonyms: LOC381204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 381204
Homologene: 21124
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Cep89
Name: centrosomal protein 89
Synonyms: Ccdc123, 2610507L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72140
Homologene: 12444
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73368
Homologene: 75138
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239833
Homologene: 13198
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98733
1110017D15Rik
Name: RIKEN cDNA 1110017D15 gene
Synonyms: Cbe1, Smrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73721
Homologene: 13074
Try4
Name: trypsin 4
Synonyms: Td, 0910001B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22074
HGNC: HGNC:9486
Homologene: 106639
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22341
Homologene: 3962
Prodh2
Name: proline dehydrogenase (oxidase) 2
Synonyms: POX1, MmPOX1, 2510038B11Rik, 2510028N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56189
Homologene: 36381
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: CN-IB, 4921514H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70881
Homologene: 12370
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216021
Homologene: 17649
Slc52a2
Name: solute carrier protein 52, member 2
Synonyms: D15Ertd747e, 2010003P03Rik, Gpr172b, PAR2, GPCR42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 52710
VEGA: 15
Homologene: 56994
Golim4
Name: golgi integral membrane protein 4
Synonyms: Golph4, 3110027H23Rik, P138, GPP130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 73124
Homologene: 8716
Lad1
Name: ladinin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Kcne4
Name: potassium voltage-gated channel, Isk-related subfamily, gene 4
Synonyms: MiRP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57814
HGNC: HGNC:6244
Homologene: 10959
4930503E14Rik
Name: RIKEN cDNA 4930503E14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74954
Homologene: 115686
Gm28417
Name: predicted gene 28417
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Gm17690
Name: predicted gene, 17690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 6,274,272 bp
  • C to A, chromosome 1 at 34,471,686 bp
  • A to T, chromosome 1 at 46,126,680 bp
  • A to T, chromosome 1 at 75,490,902 bp
  • A to T, chromosome 1 at 78,817,934 bp
  • A to G, chromosome 1 at 135,828,746 bp
  • A to G, chromosome 1 at 181,203,089 bp
  • A to T, chromosome 2 at 120,182,713 bp
  • A to G, chromosome 2 at 150,659,903 bp
  • A to G, chromosome 2 at 157,464,653 bp
  • C to T, chromosome 2 at 181,001,250 bp
  • T to G, chromosome 3 at 75,895,040 bp
  • G to T, chromosome 3 at 88,096,986 bp
  • T to C, chromosome 3 at 96,167,891 bp
  • A to T, chromosome 3 at 127,225,762 bp
  • T to C, chromosome 4 at 41,505,574 bp
  • G to T, chromosome 4 at 136,011,242 bp
  • T to A, chromosome 4 at 136,011,265 bp
  • G to A, chromosome 5 at 41,820,527 bp
  • A to G, chromosome 5 at 135,137,399 bp
  • C to T, chromosome 6 at 41,304,971 bp
  • T to C, chromosome 6 at 60,944,586 bp
  • G to A, chromosome 6 at 115,935,230 bp
  • A to G, chromosome 7 at 25,307,129 bp
  • G to A, chromosome 7 at 30,506,452 bp
  • A to G, chromosome 7 at 35,416,397 bp
  • A to T, chromosome 8 at 54,181,095 bp
  • A to T, chromosome 9 at 44,809,780 bp
  • A to T, chromosome 10 at 34,152,636 bp
  • A to T, chromosome 10 at 50,981,612 bp
  • A to G, chromosome 10 at 52,162,704 bp
  • T to C, chromosome 10 at 59,428,103 bp
  • T to C, chromosome 10 at 62,659,569 bp
  • C to T, chromosome 10 at 82,151,482 bp
  • G to A, chromosome 12 at 10,391,231 bp
  • C to T, chromosome 12 at 31,660,854 bp
  • G to A, chromosome 12 at 73,181,827 bp
  • T to C, chromosome 13 at 100,030,861 bp
  • T to A, chromosome 13 at 113,043,148 bp
  • T to A, chromosome 14 at 44,169,233 bp
  • G to A, chromosome 14 at 47,724,930 bp
  • T to C, chromosome 15 at 76,537,724 bp
  • A to G, chromosome 15 at 81,889,383 bp
  • A to G, chromosome 15 at 85,927,999 bp
  • C to T, chromosome 15 at 85,963,133 bp
  • A to G, chromosome 16 at 16,342,695 bp
  • T to G, chromosome 16 at 33,109,850 bp
  • A to T, chromosome 18 at 10,080,514 bp
  • A to T, chromosome 18 at 73,930,538 bp
  • T to C, chromosome 19 at 6,115,551 bp
  • A to G, chromosome 19 at 47,953,041 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4414 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041694-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.