Strain Name:
C57BL/6J-MtgxR4438Btlr/Mmmh
Stock Number:
041703-MU
Citation ID:
RRID:MMRRC_041703-MU
Other Names:
R4438 (G1), C57BL/6J-MtgxR4438Btlr
Major Collection:

Gene Information

Gpr83
Name: G protein-coupled receptor 83
Synonyms: RP105, RP82, RP39, glucocorticoid-induced receptor, GIR, Gpr72, Gir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14608
HGNC: HGNC:4523
Homologene: 7732
Lias
Name: lipoic acid synthetase
Synonyms: MGC7254, mLip1, 4933425M12Rik, 2900022L22Rik, 7a5ex
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79464
Homologene: 4997
Csnk1e
Name: casein kinase 1, epsilon
Synonyms: CKI epsilon, tau, KC1epsilon, CKIepsilon, CK1epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27373
HGNC: HGNC:2453
Homologene: 121695
Zfp568
Name: zinc finger protein 568
Synonyms: LOC381866, chato
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243905
Homologene: 136307
Srfbp1
Name: serum response factor binding protein 1
Synonyms: 2810036K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67222
VEGA: 18
Homologene: 12101
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Cdc37l1
Name: cell division cycle 37-like 1
Synonyms: 2700033A15Rik, Hsp90-associating relative of Cdc37, Harc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67072
VEGA: 19
Homologene: 9912
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Ttk
Name: Ttk protein kinase
Synonyms: Esk1, Mps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22137
Homologene: 2489
Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
Synonyms: Narc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100102
Homologene: 17790
Siah1b
Name: siah E3 ubiquitin protein ligase 1B
Synonyms: Sinh1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 20438
Homologene: 56441
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: DR6, TR7, Death receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Bek, KGFRTr, Fgfr-7, Fgfr-2, Fgfr7, svs, Fgfr2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233904
Homologene: 52251
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Tmub1
Name: transmembrane and ubiquitin-like domain containing 1
Synonyms: Hops, 2010004O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 64295
Homologene: 11187
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Dync2i2
Name: dynein 2 intermediate chain 2
Synonyms: 3200002I06Rik, Wdr34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71820
Homologene: 14156
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly51, Ly-51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cyp2j7
Name: cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms: OTTMUSG00000007941, Cyp2j7-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546837
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545874
Homologene: 135915
Moxd2
Name: monooxygenase, DBH-like 2
Synonyms: Dbhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194357
Homologene: 77226
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320747
Homologene: 18563
Adck1
Name: aarF domain containing kinase 1
Synonyms: 2610005A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72113
VEGA: 12
Homologene: 6493
Snx19
Name: sorting nexin 19
Synonyms: 3526401K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102607
VEGA: 9
Homologene: 8846
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235633
Homologene: 17152
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Zfp91
Name: zinc finger protein 91
Synonyms: Pzf, 9130014I08Rik, A530054C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109910
Homologene: 43144
Dpy19l3
Name: dpy-19-like 3 (C. elegans)
Synonyms: 9330164H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233115
Homologene: 18692
Bst1
Name: bone marrow stromal cell antigen 1
Synonyms: 114/A10, Ly65, Bp3, Bsta1, CD157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12182
HGNC: HGNC:1118
Homologene: 3198
Rln1
Name: relaxin 1
Synonyms: rlx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19773
Homologene: 55524
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238405
Homologene: 128362
Pramel14
Name: PRAME like 14
Synonyms: Gm13107, Pramef17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626943
Homologene: 129642
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56233
Homologene: 9124
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214704
Homologene: 44790
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67538
Homologene: 15436
Olfr725
Name: olfactory receptor 725
Synonyms: GA_x6K02T2PMLR-5725741-5724776, MOR246-3, MOR246-7_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258314
Homologene: 44957
Olfr441
Name: olfactory receptor 441
Synonyms: GA_x6K02T2P3E9-4442577-4441645, MOR261-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258649
Homologene: 88438
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223337
Homologene: 122787
Olfr1408
Name: olfactory receptor 1408
Synonyms: GA_x6K02T2R7CC-715776-716708, MOR267-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258759
Homologene: 128062
Bcl2a1d
Name: B cell leukemia/lymphoma 2 related protein A1d
Synonyms: A1-d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12047
HGNC: HGNC:991
Homologene: 2988
Gm14409
Name: predicted gene 14409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Hypk
Name: huntingtin interacting protein K
Synonyms: 2310003F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67693
Homologene: 9498
Gm5849
Name: predicted gene 5849
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
RP23-184I13.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Heatr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,831,027 bp
  • T to C, chromosome 1 at 72,611,478 bp
  • C to A, chromosome 1 at 173,130,302 bp
  • A to C, chromosome 2 at 30,048,843 bp
  • T to A, chromosome 2 at 58,477,727 bp
  • A to T, chromosome 2 at 121,457,994 bp
  • T to A, chromosome 2 at 164,820,643 bp
  • T to G, chromosome 2 at 177,265,096 bp
  • T to A, chromosome 3 at 90,777,875 bp
  • T to C, chromosome 3 at 94,402,897 bp
  • T to G, chromosome 3 at 129,284,091 bp
  • A to G, chromosome 4 at 32,704,635 bp
  • T to C, chromosome 4 at 64,007,829 bp
  • G to T, chromosome 4 at 96,217,409 bp
  • G to T, chromosome 4 at 106,458,959 bp
  • T to C, chromosome 4 at 143,991,622 bp
  • A to C, chromosome 5 at 24,446,070 bp
  • A to T, chromosome 5 at 43,825,340 bp
  • T to C, chromosome 5 at 65,395,444 bp
  • T to A, chromosome 5 at 139,163,392 bp
  • C to A, chromosome 6 at 7,675,320 bp
  • C to A, chromosome 6 at 24,505,868 bp
  • T to A, chromosome 6 at 40,884,062 bp
  • T to C, chromosome 6 at 43,116,287 bp
  • C to T, chromosome 6 at 48,487,353 bp
  • A to G, chromosome 6 at 123,839,797 bp
  • G to T, chromosome 7 at 30,022,296 bp
  • A to G, chromosome 7 at 35,692,859 bp
  • A to G, chromosome 7 at 127,785,731 bp
  • G to A, chromosome 7 at 130,172,930 bp
  • G to A, chromosome 7 at 130,623,541 bp
  • T to C, chromosome 9 at 14,864,838 bp
  • G to T, chromosome 9 at 30,428,599 bp
  • A to G, chromosome 9 at 83,839,813 bp
  • A to T, chromosome 9 at 88,731,700 bp
  • T to C, chromosome 9 at 110,885,398 bp
  • G to T, chromosome 10 at 38,965,987 bp
  • C to T, chromosome 12 at 88,431,150 bp
  • A to C, chromosome 12 at 113,490,661 bp
  • T to C, chromosome 14 at 50,034,830 bp
  • A to T, chromosome 15 at 9,351,197 bp
  • G to A, chromosome 15 at 47,899,795 bp
  • C to A, chromosome 15 at 55,603,215 bp
  • A to T, chromosome 15 at 79,420,929 bp
  • T to C, chromosome 15 at 97,807,715 bp
  • G to T, chromosome 17 at 43,087,842 bp
  • T to C, chromosome 18 at 52,488,331 bp
  • C to A, chromosome 19 at 12,778,021 bp
  • T to C, chromosome 19 at 29,007,621 bp
  • A to T, chromosome 19 at 29,334,562 bp
  • G to A, chromosome X at 164,071,692 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4438 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041703-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.