Strain Name:
C57BL/6J-MtgxR4470Btlr/Mmmh
Stock Number:
041727-MU
Citation ID:
RRID:MMRRC_041727-MU
Other Names:
R4470 (G1), C57BL/6J-MtgxR4470Btlr
Major Collection:

Gene Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Wnt-3, Int-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22415
Homologene: 22527
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rho-kinase, Rock-II, Rock2m, B230113H15Rik, ROKalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Ddx19a
Name: DEAD box helicase 19a
Synonyms: DBP5, Eif4a-rs1, Ddx19, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13680
Homologene: 5240
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, TAF2B, 150kDa, TAFII150, 4732460C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Atp13a1
Name: ATPase type 13A1
Synonyms: Atp13a, catp, Cgi152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Icam5
Name: intercellular adhesion molecule 5, telencephalin
Synonyms: CD50, Icam3, TLN, Tlcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15898
VEGA: 9
HGNC: HGNC:5348
Homologene: 2447
Adcy1
Name: adenylate cyclase 1
Synonyms: D11Bwg1392e, I-AC, AC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21341
Homologene: 21163
Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms: Kir3.1, GIRK1, Kcnf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16519
HGNC: HGNC:6264
Homologene: 1687
Zfp148
Name: zinc finger protein 148
Synonyms: BFCOL1, ZBP-89, beta enolase repressor factor 1, 2210405J08Rik, BERF-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: ATP-dependent metalloprotease FtsH1, Ftsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27377
Homologene: 31996
Ddx41
Name: DEAD box helicase 41
Synonyms: 2900024F02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Il16
Name: interleukin 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
H2-K1
Name: histocompatibility 2, K1, K region
Synonyms: H-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14972
HGNC: HGNC:4931
Homologene: 128352
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216874
Homologene: 9021
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Trim69
Name: tripartite motif-containing 69
Synonyms: 4921519C19Rik, Rnf36, Trif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70928
Homologene: 18827
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56517
Homologene: 137336
Olfr891
Name: olfactory receptor 891
Synonyms: GA_x6K02T2PVTD-31862167-31861217, MOR170-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258471
Homologene: 74210
Olfr771
Name: olfactory receptor 771
Synonyms: GA_x6K02T2PULF-10846420-10845467, MOR114-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258540
Homologene: 74047
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Fmo9
Name: flavin containing monooxygenase 9
Synonyms: 4831428F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240894
Homologene: 134192
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22313
Homologene: 129751
Nrxn3
Name: neurexin III
Synonyms: neurexin III alpha, neurexin III beta, 9330112C09Rik, 4933401A11Rik, neurexin III beta, D12Bwg0831e, neurexin III alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64899
Homologene: 84844
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627805
Homologene: 129678
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: ADAM-TS1, ADAMTS-1, METH1, METH-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Mylk
Name: myosin, light polypeptide kinase
Synonyms: Mlck, MLCK108, telokin, 9530072E15Rik, A930019C19Rik, MLCK210, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: LOC384945, EG330963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Tmem9
Name: transmembrane protein 9
Synonyms: 1500015G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66241
Homologene: 9515
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628580
Homologene: 120153
A330008L17Rik
Name: RIKEN cDNA A330008L17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234624
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20678
Homologene: 21378
Tbx4
Name: T-box 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21387
Homologene: 7968
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71481
Homologene: 11849
Olfr1219
Name: olfactory receptor 1219
Synonyms: GA_x6K02T2Q125-50555603-50554668, MOR233-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258901
Homologene: 27292
Gmeb2
Name: glucocorticoid modulatory element binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229004
HGNC: HGNC:4371
Homologene: 8228
Pramel5
Name: PRAME like 5
Synonyms: OTTMUSG00000010540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384077
Homologene: 133722
Olfr1428
Name: olfactory receptor 1428
Synonyms: GA_x6K02T2RE5P-2468394-2467450, MOR239-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258673
Homologene: 17339
Olfr26
Name: olfactory receptor 26
Synonyms: MOR171-9, GA_x6K02T2PVTD-32550930-32551856, MTPCR09
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: acid ceramidase, 2310081N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Myzap
Name: myocardial zonula adherens protein
Synonyms: Grinl1a7, Myozap, Gcom1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102371
Homologene: 134156
Man1b1
Name: mannosidase, alpha, class 1B, member 1
Synonyms: LOC227619, E430019H13Rik, MANA-ER
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227619
HGNC: HGNC:6823
Homologene: 5230
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Olfr66
Name: olfactory receptor 66
Synonyms: MOR1-3, 5'[b]1, GA_x6K02T2PBJ9-6620959-6620024
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18367
Homologene: 88376
Olfr345
Name: olfactory receptor 345
Synonyms: GA_x6K02T2NLDC-33334179-33335114, MOR136-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258947
Homologene: 45069
Zfp41
Name: zinc finger protein 41
Synonyms: CTfin92, Zfp-41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22701
Homologene: 65280
Msc
Name: musculin
Synonyms: bHLHa22, MyoR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17681
HGNC: HGNC:7321
Homologene: 3738
Rps18-ps3
Name: ribosomal protein S18, pseudogene 3
Synonyms: Gm10027
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100042791
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 14,755,678 bp
  • T to A, chromosome 1 at 46,748,635 bp
  • A to G, chromosome 1 at 136,027,496 bp
  • T to A, chromosome 1 at 166,680,230 bp
  • T to C, chromosome 2 at 23,186,332 bp
  • C to G, chromosome 2 at 25,332,855 bp
  • T to C, chromosome 2 at 36,640,221 bp
  • A to T, chromosome 2 at 55,437,865 bp
  • T to C, chromosome 2 at 89,075,038 bp
  • A to G, chromosome 2 at 122,178,599 bp
  • A to G, chromosome 2 at 160,895,434 bp
  • A to T, chromosome 2 at 181,265,145 bp
  • T to C, chromosome 3 at 72,928,159 bp
  • A to G, chromosome 3 at 127,679,526 bp
  • T to C, chromosome 4 at 144,271,345 bp
  • A to T, chromosome 5 at 125,102,641 bp
  • A to G, chromosome 6 at 143,844,765 bp
  • A to T, chromosome 7 at 10,527,348 bp
  • A to G, chromosome 7 at 83,650,838 bp
  • G to A, chromosome 7 at 103,881,749 bp
  • A to G, chromosome 8 at 41,343,724 bp
  • T to C, chromosome 8 at 69,798,679 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • T to A, chromosome 8 at 99,416,689 bp
  • T to A, chromosome 8 at 107,263,130 bp
  • A to G, chromosome 8 at 110,976,479 bp
  • T to C, chromosome 8 at 119,599,622 bp
  • C to T, chromosome 8 at 121,651,759 bp
  • T to A, chromosome 9 at 21,035,506 bp
  • A to G, chromosome 9 at 38,180,370 bp
  • T to C, chromosome 9 at 38,855,631 bp
  • T to C, chromosome 9 at 65,503,509 bp
  • A to G, chromosome 9 at 71,592,281 bp
  • T to C, chromosome 10 at 10,398,951 bp
  • T to A, chromosome 10 at 39,080,496 bp
  • G to A, chromosome 10 at 129,160,514 bp
  • A to G, chromosome 11 at 7,144,804 bp
  • T to A, chromosome 11 at 53,956,013 bp
  • T to C, chromosome 11 at 70,680,940 bp
  • A to G, chromosome 11 at 85,912,122 bp
  • A to G, chromosome 11 at 103,812,624 bp
  • C to T, chromosome 12 at 16,971,275 bp
  • T to C, chromosome 12 at 90,204,741 bp
  • G to A, chromosome 13 at 55,534,480 bp
  • T to C, chromosome 15 at 55,058,880 bp
  • A to G, chromosome 15 at 75,618,519 bp
  • T to C, chromosome 16 at 33,496,232 bp
  • A to G, chromosome 16 at 34,912,152 bp
  • A to C, chromosome 16 at 85,798,516 bp
  • G to T, chromosome 17 at 20,042,241 bp
  • T to A, chromosome 17 at 20,462,728 bp
  • G to A, chromosome 17 at 34,000,061 bp
  • C to T, chromosome 17 at 46,538,336 bp
  • T to C, chromosome 19 at 12,109,183 bp
  • G to T, chromosome 19 at 27,234,819 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4470 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041727-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.