Strain Name:
C57BL/6J-MtgxR4484Btlr/Mmmh
Stock Number:
041740-MU
Citation ID:
RRID:MMRRC_041740-MU
Other Names:
R4484 (G1), C57BL/6J-MtgxR4484Btlr
Major Collection:

Gene Information

Strap
Name: serine/threonine kinase receptor associated protein
Synonyms: Unrip, C78091
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20901
Homologene: 43881
Mkks
Name: McKusick-Kaufman syndrome
Synonyms: 1300013E18Rik, Bbs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59030
HGNC: HGNC:7108
Homologene: 10318
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: 1200014D22Rik, LIP1, LKB1IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71728
Homologene: 12406
Med15
Name: mediator complex subunit 15
Synonyms: Pcqap, A230074L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94112
VEGA: 16
Zfp622
Name: zinc finger protein 622
Synonyms: ZPR9, 1110033B05Rik, D15Ertd806e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 52521
VEGA: 15
Homologene: 74377
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Cd164l2
Name: CD164 sialomucin-like 2
Synonyms: 2310047N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69655
Homologene: 19231
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: D8Wsu49e, 2310047C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71927
Homologene: 12423
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 9330170P05Rik, Epac1, 2310016P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223864
Homologene: 21231
BC067074
Name: cDNA sequence BC067074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408066
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637873
Homologene: 129683
Junb
Name: jun B proto-oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16477
HGNC: HGNC:6205
Homologene: 7390
Tppp2
Name: tubulin polymerization-promoting protein family member 2
Synonyms: LOC386487, LOC219038
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219038
VEGA: 14
Homologene: 25079
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 378431
Homologene: 44534
Gm15759
Name: predicted gene 15759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636191
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, Fmi1, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107141
Homologene: 137231
Snx19
Name: sorting nexin 19
Synonyms: 3526401K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102607
VEGA: 9
Homologene: 8846
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: 4930417M19Rik, FetA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Igtp
Name: interferon gamma induced GTPase
Synonyms: Irgm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16145
Homologene: 23118
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 1200008A14Rik, 4932441F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71710
Homologene: 12559
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233315
Homologene: 9822
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171195
Homologene: 137652
Cr2
Name: complement receptor 2
Synonyms: CD35, Cr1, C3DR, CD21, Cr-2, Cr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22768
Homologene: 56456
Rxrg
Name: retinoid X receptor gamma
Synonyms: Nr2b3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20183
Homologene: 21373
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72344
Homologene: 11828
Vmn1r6
Name: vomeronasal 1 receptor 6
Synonyms: V1rc20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171193
Homologene: 128340
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101613
Homologene: 15881
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 6332415K15Rik, 2610312F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70461
Homologene: 11248
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228536
Homologene: 8976
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: DC-STAMP, 4833414I07Rik, Tm7sf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75766
VEGA: 15
Homologene: 12769
Tgtp2
Name: T cell specific GTPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100039796
Homologene: 129991
Gprin2
Name: G protein regulated inducer of neurite outgrowth 2
Synonyms: C130040D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 432839
VEGA: 14
Homologene: 40975
Ttc39c
Name: tetratricopeptide repeat domain 39C
Synonyms: 2810439F02Rik, 1700008N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72747
Homologene: 124438
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: Nim1, E130304F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Gm13032
Name: predicted gene 13032
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100049161
Gm20422
Name: predicted gene 20422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
AC153941.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ighv5-6
Name: immunoglobulin heavy variable 5-6
Synonyms: Gm16891
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 777780
Gm44501
Name: predicted readthrough transcript, 44501
Synonyms: Esp6Esp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 102577428
VEGA: 17
Homologene: 136357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,262,571 bp
  • G to A, chromosome 1 at 75,527,072 bp
  • T to C, chromosome 1 at 167,625,027 bp
  • T to C, chromosome 1 at 195,154,174 bp
  • C to T, chromosome 2 at 118,916,406 bp
  • T to C, chromosome 2 at 136,880,574 bp
  • A to G, chromosome 2 at 160,960,127 bp
  • A to T, chromosome 3 at 14,551,443 bp
  • C to A, chromosome 3 at 110,143,808 bp
  • T to C, chromosome 4 at 43,357,016 bp
  • T to A, chromosome 4 at 133,223,675 bp
  • G to T, chromosome 4 at 140,817,270 bp
  • A to G, chromosome 6 at 57,003,189 bp
  • A to T, chromosome 6 at 58,435,133 bp
  • T to C, chromosome 6 at 137,749,336 bp
  • G to A, chromosome 7 at 42,300,696 bp
  • T to C, chromosome 7 at 64,320,631 bp
  • T to C, chromosome 7 at 80,589,948 bp
  • A to G, chromosome 7 at 140,921,781 bp
  • G to T, chromosome 7 at 141,868,450 bp
  • T to C, chromosome 8 at 69,744,485 bp
  • T to C, chromosome 8 at 84,977,888 bp
  • G to A, chromosome 8 at 85,726,249 bp
  • T to C, chromosome 9 at 30,427,896 bp
  • G to A, chromosome 9 at 108,846,063 bp
  • T to TTA, chromosome 10 at 17,838,997 bp
  • C to T, chromosome 10 at 59,223,099 bp
  • A to T, chromosome 11 at 49,059,352 bp
  • G to A, chromosome 11 at 58,206,998 bp
  • T to C, chromosome 11 at 97,335,711 bp
  • T to A, chromosome 11 at 118,285,795 bp
  • T to A, chromosome 12 at 113,625,588 bp
  • T to C, chromosome 13 at 3,581,831 bp
  • A to T, chromosome 13 at 113,319,199 bp
  • G to A, chromosome 13 at 119,712,174 bp
  • C to A, chromosome 14 at 34,194,797 bp
  • T to C, chromosome 14 at 51,919,411 bp
  • T to A, chromosome 14 at 62,411,589 bp
  • G to A, chromosome 15 at 25,987,051 bp
  • A to G, chromosome 15 at 39,754,224 bp
  • G to A, chromosome 15 at 97,758,968 bp
  • A to T, chromosome 16 at 17,671,564 bp
  • T to A, chromosome 17 at 40,576,616 bp
  • T to C, chromosome 18 at 12,481,088 bp
  • A to G, chromosome 18 at 12,730,069 bp
  • A to G, chromosome 19 at 40,090,639 bp
  • A to G, chromosome Y at 2,107,351 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4484 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041740-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.