Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR4491Btlr/Mmmh
Stock Number:
041747-MU
Citation ID:
RRID:MMRRC_041747-MU
Other Names:
R4491 (G1), C57BL/6J-MtgxR4491Btlr
Major Collection:

Gene Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: 5730411M05Rik, ESTM14, Bce1, Grg4, ESTM13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21888
VEGA: 19
Homologene: 38259
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319582
Homologene: 35306
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Pdzd2
Name: PDZ domain containing 2
Synonyms: A930022H17Rik, Pdzk3, Gm21706, 4930537L06Rik, LOC223364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68070
Homologene: 23393
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320528
VEGA: 9
Homologene: 41188
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: Depdc2, 6230420N16Rik, C030045D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109294
Homologene: 23523
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: Taf2n, 68kDa, TAFII68, 2610111C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70439
Homologene: 131088
Nomo1
Name: nodal modulator 1
Synonyms: D7Ertd156e, Nomo, PM5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 211548
Homologene: 13810
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 55935
Homologene: 9087
Bzw1
Name: basic leucine zipper and W2 domains 1
Synonyms: 1200015E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66882
Homologene: 41651
Dmtf1
Name: cyclin D binding myb-like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23857
Homologene: 8017
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230393
Homologene: 9842
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: Grf2, 4932418O06Rik, C3G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12032
Homologene: 7244
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Zfp37
Name: zinc finger protein 37
Synonyms: Zfp-37, Tzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22696
Homologene: 40682
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: Band 8A, B56/PP2A gamma, 2700063L20Rik, 2610043M05Rik, D12Bwg0916e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Ubxn10
Name: UBX domain protein 10
Synonyms: 5730509E04Rik, Ubxd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 212190
Homologene: 17568
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83379
Homologene: 12820
C030017K20Rik
Name: RIKEN cDNA C030017K20 gene
Synonyms: LOC381581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: null
Ensembl: null
VEGA: null
HGNC: null
Homologene: null
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242505
Homologene: 28424
Zfp648
Name: zinc finger protein 648
Synonyms: Gm10178, LOC207678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100503355
Homologene: 18996
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Hdhc3, Dnahc7l, LOC380889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: mSYD1A, 1200008N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71709
VEGA: 10
Homologene: 13195
Cdh5
Name: cadherin 5
Synonyms: VEC, CD144, VEcad, VE-cadherin, 7B4/cadherin-5, VE-Cad, VECD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232237
Homologene: 27798
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320558
Homologene: 8604
Rasal3
Name: RAS protein activator like 3
Synonyms: A430107D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320484
Homologene: 18901
Wdr78
Name: WD repeat domain 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242584
Homologene: 11702
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 665033
Homologene: 122792
Tmem30a
Name: transmembrane protein 30A
Synonyms: D9Wsu20e, Cdc50a, 2010200I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69981
Homologene: 110703
Elmod3
Name: ELMO/CED-12 domain containing 3
Synonyms: RBM29, Rbed1, C330008I15Rik, ELMOD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232089
Homologene: 12978
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Hbb-bh2
Name: hemoglobin beta, bh2
Synonyms: Gm5736
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 436003
HGNC: null
Homologene: null
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 101055671
HGNC: null
Homologene: 103863
Olfr683
Name: olfactory receptor 683
Synonyms: GA_x6K02T2PBJ9-7773007-7772066, MOR40-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259047
Homologene: 133645
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76261
Homologene: 49537
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, Gm1564, LOC268491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268491
Homologene: 19559
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330450
Homologene: 69247
Olfr1130
Name: olfactory receptor 1130
Synonyms: MOR264-4, GA_x6K02T2Q125-49112575-49113519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258835
HGNC: null
Homologene: 133705
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269437
Homologene: 88833
Olfr1353
Name: olfactory receptor 1353
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 259044
HGNC: null
Homologene: 131345
Epha1
Name: Eph receptor A1
Synonyms: 5730453L17Rik, Esk, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: LRG-47, Ifi1, Irgm, Iigp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15944
HGNC: null
Homologene: 134089
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74419
Homologene: 69456
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171241
HGNC: null
Homologene: 44234
Igsf5
Name: immunoglobulin superfamily, member 5
Synonyms: Jam4, Igsf5, 2010003D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 72058
HGNC: HGNC:5952
Homologene: 12437
Colca2
Name: COLCA2 homolog
Synonyms: Gm684, LOC270157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100502940
VEGA: 9
Homologene: 19023
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20129
Homologene: 84780
Taf1
Name: TATA-box binding protein associated factor 1
Synonyms: Taf2a, KAT4, B430306D02Rik, Ccg-1, Ccg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 270627
Homologene: 37942
Ighv7-2
Name: immunoglobulin heavy variable 7-2
Synonyms: Gm16699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 780800
HGNC: null
Homologene: null
Defb6
Name: defensin beta 6
Synonyms: mBD-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 116746
HGNC: null
Homologene: null
Gm14193
Name: predicted gene 14193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,162,263 bp
  • T to A, chromosome 1 at 58,404,259 bp
  • T to G, chromosome 1 at 154,205,127 bp
  • C to T, chromosome 2 at 29,719,656 bp
  • G to A, chromosome 2 at 87,607,392 bp
  • T to C, chromosome 2 at 90,752,968 bp
  • G to T, chromosome 2 at 156,522,168 bp
  • A to G, chromosome 2 at 172,249,203 bp
  • G to T, chromosome 2 at 178,374,985 bp
  • T to C, chromosome 3 at 63,740,739 bp
  • G to A, chromosome 3 at 87,990,233 bp
  • A to T, chromosome 3 at 93,396,511 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 4 at 62,192,128 bp
  • A to C, chromosome 4 at 73,734,503 bp
  • G to A, chromosome 4 at 88,359,905 bp
  • T to C, chromosome 4 at 103,066,399 bp
  • T to C, chromosome 4 at 138,734,408 bp
  • T to C, chromosome 4 at 155,429,171 bp
  • A to G, chromosome 5 at 9,140,379 bp
  • C to A, chromosome 5 at 63,898,469 bp
  • A to G, chromosome 5 at 65,375,794 bp
  • T to C, chromosome 6 at 42,360,666 bp
  • T to C, chromosome 6 at 72,587,620 bp
  • A to G, chromosome 6 at 91,989,299 bp
  • T to C, chromosome 6 at 148,173,409 bp
  • C to A, chromosome 7 at 11,880,982 bp
  • A to G, chromosome 7 at 46,083,650 bp
  • T to C, chromosome 7 at 103,840,415 bp
  • A to T, chromosome 7 at 105,143,776 bp
  • A to T, chromosome 8 at 19,228,074 bp
  • G to A, chromosome 8 at 36,505,606 bp
  • T to C, chromosome 8 at 66,512,012 bp
  • A to T, chromosome 8 at 104,113,040 bp
  • A to G, chromosome 9 at 51,270,655 bp
  • C to T, chromosome 9 at 67,910,193 bp
  • T to C, chromosome 9 at 79,777,285 bp
  • C to T, chromosome 9 at 105,940,012 bp
  • C to T, chromosome 10 at 78,590,228 bp
  • T to C, chromosome 10 at 78,970,317 bp
  • T to C, chromosome 10 at 115,470,596 bp
  • G to A, chromosome 11 at 48,866,128 bp
  • A to T, chromosome 11 at 83,484,694 bp
  • T to A, chromosome 11 at 99,730,313 bp
  • A to G, chromosome 11 at 102,674,920 bp
  • A to T, chromosome 12 at 110,580,522 bp
  • A to G, chromosome 12 at 113,912,480 bp
  • T to C, chromosome 14 at 26,734,603 bp
  • C to T, chromosome 15 at 12,385,637 bp
  • A to C, chromosome 15 at 76,597,722 bp
  • A to G, chromosome 16 at 96,364,081 bp
  • T to A, chromosome 17 at 32,391,385 bp
  • T to C, chromosome 18 at 20,001,865 bp
  • G to A, chromosome 18 at 47,306,457 bp
  • A to G, chromosome 19 at 14,454,865 bp
  • A to C, chromosome 19 at 33,721,700 bp
  • G to T, chromosome X at 101,543,059 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4491 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.