Strain Name:
C57BL/6J-MtgxR4502Btlr/Mmmh
Stock Number:
041754-MU
Citation ID:
RRID:MMRRC_041754-MU
Other Names:
R4502 (G1), C57BL/6J-MtgxR4502Btlr
Major Collection:

Gene Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: mBSC1, Nkcc2, urehr3, D630042G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20495
Homologene: 286
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: Htr2, Htr-2, 5-HT2A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Ldb2
Name: LIM domain binding 2
Synonyms: CLIM-1b, CLP-36, CLIM1, Ldb3, CLIM-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16826
HGNC: HGNC:6533
Homologene: 989
Dst
Name: dystonin
Synonyms: nmf203, ah, bullous pemphigoid antigen 1, nmf339, Bpag1, 2310001O04Rik, bullous pemphigoid antigen 1, BPAG1-n, athetoid, BPAG1, Macf2, A830042E19Rik, Bpag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 9030227G01Rik, 2310004H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: Mypt1, 1200015F06Rik, 5730577I22Rik, D10Ertd625e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Slc49a4
Name: solute carrier family 49 member 4
Synonyms: Dirc2, RCC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224132
Homologene: 13137
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 6330512O03Rik, D10Ertd516e, 2310038O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71902
Homologene: 10202
Tmem131
Name: transmembrane protein 131
Synonyms: YR-23, Rw1, Neg, CC28, 2610524E03Rik, D1Bwg0491e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242553
Homologene: 18244
Chodl
Name: chondrolectin
Synonyms: 3110074E07Rik, MT75, PRED12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246048
Homologene: 11795
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Scpep1
Name: serine carboxypeptidase 1
Synonyms: Risc, 2410018F01Rik, 4833411K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74617
Homologene: 41443
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, 4930473A06Rik, A330015D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
Sil1
Name: endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
Synonyms: 1810057E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 81500
VEGA: 18
Homologene: 32544
Eea1
Name: early endosome antigen 1
Synonyms: A430109M19Rik, B230358H09Rik, ZFYVE2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228140
Homologene: 14117
Cep295
Name: centrosomal protein 295
Synonyms: 5830418K08Rik, LOC382128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Rpl5
Name: ribosomal protein L5
Synonyms: U21RNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100503670
Homologene: 110649
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Ulk3
Name: unc-51-like kinase 3
Synonyms: 1200015E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71742
VEGA: 9
Homologene: 68482
Hc
Name: hemolytic complement
Synonyms: C5a, He, Hfib2, C5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: PGC-1beta/ERRL1, 4631412G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214575
Homologene: 18312
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624765
Homologene: 83483
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Arf5
Name: ADP-ribosylation factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11844
HGNC: HGNC:658
Homologene: 129625
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, Plcl4, PLCeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Slc2a9
Name: solute carrier family 2 (facilitated glucose transporter), member 9
Synonyms: Glut9, SLC2a9A, SLC2A9B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117591
Homologene: 69290
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Angtr-1b, AT1B, Agtr-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Vps33b
Name: vacuolar protein sorting 33B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233405
Homologene: 10261
G930045G22Rik
Name: RIKEN cDNA G930045G22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Olfr1370
Name: olfactory receptor 1370
Synonyms: GA_x6K02T2QHY8-12181473-12182423, MOR256-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258528
Homologene: 105231
Ldhb
Name: lactate dehydrogenase B
Synonyms: H-Ldh, Ldh-2, lactate dehydrogenase-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16832
HGNC: HGNC:6541
Homologene: 55647
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237411
Homologene: 135924
Rbbp8nl
Name: RBBP8 N-terminal like
Synonyms: BC066135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271887
Homologene: 76811
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74691
Homologene: 14311
Bmp8a
Name: bone morphogenetic protein 8a
Synonyms: osteogenic protein 2, Bmp7r1, OP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12163
Homologene: 135983
Olfr303
Name: olfactory receptor 303
Synonyms: GA_x6K02T2NHDJ-9712819-9713778, MOR104-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258612
Homologene: 105157
Olfr178
Name: olfactory receptor 178
Synonyms: GA_x54KRFPKG5P-55108059-55107100, MOR184-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258999
Homologene: 79412
Atp6v0d1
Name: ATPase, H+ transporting, lysosomal V0 subunit D1
Synonyms: lysosomal 38kDa, Atp6d, Ac39, P39, Vma6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11972
Homologene: 3444
Wnt9a
Name: wingless-type MMTV integration site family, member 9A
Synonyms: Wnt14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216795
Homologene: 20722
Zfp689
Name: zinc finger protein 689
Synonyms: 4933416E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71131
Homologene: 16318
Gm10550
Name: predicted gene 10550
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 34,247,691 bp
  • T to C, chromosome 1 at 36,825,479 bp
  • T to C, chromosome 1 at 45,348,677 bp
  • T to C, chromosome 1 at 93,750,987 bp
  • G to A, chromosome 1 at 125,677,991 bp
  • G to T, chromosome 1 at 140,507,747 bp
  • T to A, chromosome 1 at 156,300,764 bp
  • T to C, chromosome 2 at 35,006,252 bp
  • C to T, chromosome 2 at 85,062,647 bp
  • T to A, chromosome 2 at 125,226,044 bp
  • G to T, chromosome 2 at 180,279,196 bp
  • A to C, chromosome 3 at 20,315,798 bp
  • T to A, chromosome 3 at 94,996,607 bp
  • G to T, chromosome 3 at 118,797,537 bp
  • A to G, chromosome 4 at 83,864,323 bp
  • G to A, chromosome 4 at 98,777,098 bp
  • T to A, chromosome 4 at 123,342,399 bp
  • T to C, chromosome 4 at 154,985,441 bp
  • T to C, chromosome 5 at 38,398,811 bp
  • T to C, chromosome 5 at 44,669,407 bp
  • T to C, chromosome 5 at 73,088,397 bp
  • T to C, chromosome 5 at 107,904,857 bp
  • T to C, chromosome 6 at 28,425,776 bp
  • T to C, chromosome 6 at 50,846,665 bp
  • T to C, chromosome 6 at 142,490,457 bp
  • C to T, chromosome 7 at 25,288,467 bp
  • G to A, chromosome 7 at 80,287,907 bp
  • T to A, chromosome 7 at 86,395,277 bp
  • C to A, chromosome 7 at 127,448,753 bp
  • T to C, chromosome 8 at 40,558,162 bp
  • A to G, chromosome 8 at 105,565,798 bp
  • A to G, chromosome 9 at 15,317,661 bp
  • A to G, chromosome 9 at 53,495,946 bp
  • A to G, chromosome 9 at 57,593,229 bp
  • A to T, chromosome 10 at 79,148,930 bp
  • A to G, chromosome 10 at 82,226,271 bp
  • G to A, chromosome 10 at 96,039,565 bp
  • G to T, chromosome 10 at 108,249,478 bp
  • T to C, chromosome 10 at 119,216,667 bp
  • T to C, chromosome 11 at 59,328,537 bp
  • T to C, chromosome 11 at 88,944,385 bp
  • T to C, chromosome 12 at 111,993,825 bp
  • A to T, chromosome 13 at 21,072,746 bp
  • C to T, chromosome 13 at 47,063,077 bp
  • T to A, chromosome 14 at 74,641,988 bp
  • A to G, chromosome 14 at 96,517,846 bp
  • T to C, chromosome 16 at 35,719,417 bp
  • T to C, chromosome 16 at 58,890,176 bp
  • T to C, chromosome 16 at 77,115,396 bp
  • A to G, chromosome 16 at 78,931,444 bp
  • T to C, chromosome 18 at 35,317,875 bp
  • T to C, chromosome 18 at 61,302,679 bp
  • T to C, chromosome 18 at 82,636,954 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4502 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041754-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.