Strain Name:
C57BL/6J-MtgxR4518Btlr/Mmmh
Stock Number:
041762-MU
Citation ID:
RRID:MMRRC_041762-MU
Other Names:
R4518 (G1), C57BL/6J-MtgxR4518Btlr
Major Collection:

Gene Information

Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: HAC1, trls
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15166
HGNC: HGNC:4846
Homologene: 31022
Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MommeD2, MTase, Dnmt1o, Cxxc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21899
Homologene: 21223
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: Olp-1, golgin-245
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4l, Orc4P, mMmORC4, Orc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98732
Homologene: 40842
Fam168a
Name: family with sequence similarity 168, member A
Synonyms: B930006L02Rik, 2610030B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319604
Homologene: 18702
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: Syt3-rs, 2810036I15Rik, RIM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Abr
Name: active BCR-related gene
Synonyms: 6330400K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109934
HGNC: HGNC:81
Homologene: 11081
Clca2
Name: chloride channel accessory 2
Synonyms: Clca5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229933
HGNC: HGNC:2016
Homologene: 4765
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, mGlu7a receptor, Tg(SMN2)89Ahmb, 6330570A01Rik, mGluR7, SMN2, E130018M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Prokr2
Name: prokineticin receptor 2
Synonyms: B830005M06Rik, Gpcr73l1, Gpr73l1, EG-VEGRF2, PKR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 246313
Homologene: 16368
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74241
Homologene: 11574
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98970
Homologene: 122246
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Cntrl
Name: centriolin
Synonyms: IB3/5, Ma2a8, Cep1, Cep110, b2b1468Clo, 6720467O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Cwf19l1
Name: CWF19-like 1, cell cycle control (S. pombe)
Synonyms: 2610528C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: C330012F17Rik, Girdin, GIV, HkRP1, C130096N06Rik, D130005J21Rik, A430106J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 3110009N10Rik, 8030460J03Rik, BACH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237911
Homologene: 32766
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Crppa
Name: CDP-L-ribitol pyrophosphorylase A
Synonyms: Ispd, 4930579E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75847
VEGA: 12
Homologene: 45614
Prlr
Name: prolactin receptor
Synonyms: Pr-1, Prlr-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19116
HGNC: HGNC:9446
Homologene: 733
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh4, Zfh-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Celf5
Name: CUGBP, Elav-like family member 5
Synonyms: 4930565A21Rik, Brunol5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319586
Homologene: 75172
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, PYPAF2, Pan1, E330007A02Rik, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: Fir, D030026M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227377
Homologene: 8877
Ubqlnl
Name: ubiquilin-like
Synonyms: 4922504M18Rik, LOC244179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: 1190005F20Rik, Trm1-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98685
Homologene: 12801
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: F730017E11Rik, 6330407A06Rik, Giantin, C130074L01Rik, Gm6840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Olfr1277
Name: olfactory receptor 1277
Synonyms: MOR248-11, GA_x6K02T2Q125-72321818-72320907
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258391
Homologene: 105176
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Bcl3
Name: B cell leukemia/lymphoma 3
Synonyms: Bcl-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12051
HGNC: HGNC:998
Homologene: 81738
Cckar
Name: cholecystokinin A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12425
HGNC: HGNC:1570
Homologene: 37337
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: 6720425G15Rik, Pacs1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98396
Homologene: 14871
Pdss2
Name: prenyl (solanesyl) diphosphate synthase, subunit 2
Synonyms: PLMP, kd, mDLP1, 5430420P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71365
Homologene: 56885
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: SAPLT, 1700056N23Rik, 1700042F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67331
VEGA: 10
Homologene: 19034
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Olfr39
Name: olfactory receptor 39
Synonyms: MOR144-1, GA_x6K02T2PVTD-14025733-14026668
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258822
HGNC: HGNC:8380
Homologene: 81583
Vnn3
Name: vanin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 26464
Homologene: 48295
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: 2810430O08Rik, D13Ertd275e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
St8sia6
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Synonyms: ST8Sia VI, Siat8f, 1700007J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241230
Homologene: 17112
Olfr845
Name: olfactory receptor 845
Synonyms: MOR150-2, MOR150-1, GA_x6K02T2PVTD-13076685-13077623, Olfr1522-ps1, MOR150-1P, MOR150-1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258249
Homologene: 133689
Adamtsl2
Name: ADAMTS-like 2
Synonyms: A930008K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77794
Homologene: 8798
Cyb561d1
Name: cytochrome b-561 domain containing 1
Synonyms: 1600010M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72023
Homologene: 45651
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241324
Homologene: 45474
Fam122c
Name: family with sequence similarity 122, member C
Synonyms: 4930527G05Rik, 4930432H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73866
Homologene: 87062
Dnajb4
Name: DnaJ heat shock protein family (Hsp40) member B4
Synonyms: 1700029A20Rik, 2010306G19Rik, 5730460G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67035
Homologene: 100610
Klf14
Name: Kruppel-like factor 14
Synonyms: BTEB5, 5330411L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 619665
Homologene: 76469
Gm17552
Name: predicted gene, 17552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 102631780
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 75,475,045 bp
  • A to G, chromosome 1 at 93,620,641 bp
  • T to C, chromosome 1 at 131,839,125 bp
  • C to T, chromosome 1 at 151,448,343 bp
  • G to A, chromosome 1 at 185,267,068 bp
  • T to A, chromosome 2 at 13,792,751 bp
  • T to C, chromosome 2 at 27,095,547 bp
  • A to T, chromosome 2 at 31,817,195 bp
  • A to G, chromosome 2 at 35,148,974 bp
  • C to A, chromosome 2 at 37,790,389 bp
  • G to A, chromosome 2 at 48,937,489 bp
  • C to A, chromosome 2 at 66,093,610 bp
  • T to C, chromosome 2 at 111,269,918 bp
  • T to A, chromosome 2 at 132,374,092 bp
  • T to C, chromosome 3 at 5,412,518 bp
  • G to T, chromosome 3 at 103,750,372 bp
  • T to C, chromosome 3 at 108,199,571 bp
  • A to G, chromosome 3 at 109,935,013 bp
  • T to A, chromosome 3 at 144,808,705 bp
  • T to C, chromosome 3 at 152,185,176 bp
  • T to C, chromosome 4 at 156,225,531 bp
  • T to C, chromosome 5 at 21,901,743 bp
  • T to C, chromosome 5 at 53,699,922 bp
  • A to G, chromosome 5 at 64,954,904 bp
  • A to G, chromosome 5 at 86,047,587 bp
  • A to G, chromosome 6 at 30,957,932 bp
  • A to G, chromosome 6 at 110,914,546 bp
  • T to A, chromosome 7 at 5,325,056 bp
  • T to A, chromosome 7 at 19,811,535 bp
  • C to T, chromosome 7 at 100,834,040 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • T to A, chromosome 7 at 141,644,222 bp
  • T to A, chromosome 9 at 19,339,260 bp
  • A to G, chromosome 9 at 20,286,250 bp
  • G to T, chromosome 9 at 20,911,978 bp
  • T to A, chromosome 9 at 118,559,008 bp
  • G to A, chromosome 10 at 23,867,226 bp
  • T to A, chromosome 10 at 43,372,150 bp
  • T to C, chromosome 10 at 79,724,702 bp
  • C to T, chromosome 10 at 80,523,847 bp
  • A to G, chromosome 10 at 81,476,905 bp
  • T to C, chromosome 11 at 29,482,651 bp
  • A to G, chromosome 11 at 76,472,518 bp
  • G to A, chromosome 11 at 86,077,878 bp
  • G to A, chromosome 12 at 36,473,180 bp
  • A to G, chromosome 12 at 113,060,669 bp
  • A to T, chromosome 13 at 55,476,229 bp
  • T to C, chromosome 13 at 92,521,312 bp
  • C to A, chromosome 13 at 116,895,673 bp
  • C to A, chromosome 15 at 10,328,999 bp
  • T to C, chromosome 15 at 39,437,526 bp
  • A to T, chromosome 16 at 17,096,041 bp
  • G to A, chromosome 16 at 36,929,263 bp
  • T to G, chromosome 19 at 4,170,070 bp
  • A to G, chromosome 19 at 44,133,034 bp
  • G to A, chromosome X at 53,293,499 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4518 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.